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Kumarin ve izokumarin türevlerinin anti-enflamatuar aktivite profillerinin araştırılması

Year 2021, Volume: 1 Issue: 1, 38 - 51, 12.11.2021

Zehra Arslan Murat Bingül

Abstract

Kumarinler (2H-1-benzopiran-2-on) ve izokumarinler (1H-2-benzopiran-1-on), çoğunlukla bitkilerde ve mikroorganizmalarda bulunan doğal olarak oluşan biyolojik aktif bileşiklerdir. Çok sayıda kumarin ve izokumarin türevi, farklı mekanizmalar yoluyla hafif ila çok güçlü antienflamatuar aktiviteye sahip olacak şekilde tasarlanmış, sentezlenmiş ve değerlendirilmiştir. Çok sayıda araştırma raporu, kumarin ve izokumarin ana yapısını, antienflamatuar ilaçların geliştirilmesi için potansiyel adaylar olarak göstermiştir. Bu doğal ürünlerin yapısal çeşitliliği ve biyolojik aktivitesi ile ilgili mevcut literatür gözden geçirilmiştir. Bu derleme makalesinde; çeşitli çalışmalar sonucu elde edilen antienflamatuar aktiviteye sahip doğal ve sentetik kumarin ve izokumarin türevlerinin karşılaştırmalı analizi gerçekleştirilmiş ve etkili antienflamatuar ilaçların tasarımında yol gösterici olması amacıyla kumarin ve izokumarin ana yapısı etrafında genel bir yapı-aktivite ilişkisi oluşturulmuştur.

Keywords

Kumarin izokumarin enflamasyon antienflamatuar

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Investigation of anti-Inflammatory activity profiles of coumarin and isocoumarine derivatives

Year 2021, Volume: 1 Issue: 1, 38 - 51, 12.11.2021

Zehra Arslan Murat Bingül

Abstract

Coumarins (2H-1-benzopyran-2-one) and isocumarins (1H-2-benzopyran-1-one) are naturally occurring biologically active compounds mostly found in plants as well as microorganisms. A large number of coumarin and isocoumarin derivatives have been designed, synthesized, and evaluated to have mild-to-very potent anti-inflammatory activity through different mechanisms. Numerous research reports have indicated the coumarin and isocoumarin nucleus as potential candidates for the development of anti-inflammatory drugs. The available literature on the structural diversity and biological activity of these natural products has been reviewed. In this review article; Comparative analysis of natural and synthetic coumarin and isocoumarin derivatives with anti-inflammatory activity obtained as a result of various studies was carried out and a general structure-activity relationship was established around the main structure of coumarin and isocoumarin to guide the design of effective anti-inflammatory drugs.

Keywords

Coumarin isocoumarin inflammation anti-inflammatory

References

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There are 56 citations in total.

Details

Primary Language Turkish
Journal Section Reviews
Authors

Zehra Arslan This is me 0000-0001-9169-667X

Murat Bingül 0000-0002-3909-0694

Publication Date November 12, 2021
Published in Issue Year 2021 Volume: 1 Issue: 1

Cite

APA Arslan, Z., & Bingül, M. (2021). Kumarin ve izokumarin türevlerinin anti-enflamatuar aktivite profillerinin araştırılması. Ata-Kimya Dergisi, 1(1), 38-51.
AMA Arslan Z, Bingül M. Kumarin ve izokumarin türevlerinin anti-enflamatuar aktivite profillerinin araştırılması. J Ata-Chem. November 2021;1(1):38-51.
Chicago Arslan, Zehra, and Murat Bingül. “Kumarin Ve Izokumarin türevlerinin Anti-Enflamatuar Aktivite Profillerinin araştırılması”. Ata-Kimya Dergisi 1, no. 1 (November 2021): 38-51.
EndNote Arslan Z, Bingül M (November 1, 2021) Kumarin ve izokumarin türevlerinin anti-enflamatuar aktivite profillerinin araştırılması. Ata-Kimya Dergisi 1 1 38–51.
IEEE Z. Arslan and M. Bingül, “Kumarin ve izokumarin türevlerinin anti-enflamatuar aktivite profillerinin araştırılması”, J Ata-Chem, vol. 1, no. 1, pp. 38–51, 2021.
ISNAD Arslan, Zehra - Bingül, Murat. “Kumarin Ve Izokumarin türevlerinin Anti-Enflamatuar Aktivite Profillerinin araştırılması”. Ata-Kimya Dergisi 1/1 (November 2021), 38-51.
JAMA Arslan Z, Bingül M. Kumarin ve izokumarin türevlerinin anti-enflamatuar aktivite profillerinin araştırılması. J Ata-Chem. 2021;1:38–51.
MLA Arslan, Zehra and Murat Bingül. “Kumarin Ve Izokumarin türevlerinin Anti-Enflamatuar Aktivite Profillerinin araştırılması”. Ata-Kimya Dergisi, vol. 1, no. 1, 2021, pp. 38-51.
Vancouver Arslan Z, Bingül M. Kumarin ve izokumarin türevlerinin anti-enflamatuar aktivite profillerinin araştırılması. J Ata-Chem. 2021;1(1):38-51.
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