Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 1300-9044 2667-5161 Ataturk University 10.17567/ataunidfd.290590 Health Care Administration Sağlık Kurumları Yönetimi PERİODONTAL TEDAVİDE YENİ YAKLAŞIM: İLERİ BASAMAK ÇÖZÜCÜ LİPİD MEDYATÖRLERİ Doğan Burak Kemer Doğan Esra Sinem Bolgül Behiye 11 24 2016 108 113 12 29 2015 03 18 2016 Copyright © 1986, Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 1986 Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

ÖZSağlığındevam ettirilebilmesi için akut enflamatuvar yanıtın tamamen çözülmesi vevücudun homeostazise dönmesi gerekmektedir. Enflamatuvar yanıtta rol alanlökositlerin, ortamda ölü hücre ve ürünlerini bırakma- yacak şekildekaldırılması ideal sonuç olmakla birlikte periodontal hastalıkta ve birçokfarklı sistemik hasta- lıkta, benzer şekilde kontrol altına alınamayan ve çözü-lememiş bir enflamatuvar durumun oluştuğu görülmektedir.Bugünekadar çalışılan antienflamatuvar ajanlardan steroidler, steroid olmayanantienflamatuvar ilaçlar ve antihistaminikler, akut enflamatuvar yanıtınbaşlama- sında rol alan anahtar proenflamatuvar medyatör yollarını blokeederler ve enflamasyonun kardinal bulgularının kontrolünde rol almaktadırlar.Bu terapötik yaklaşım, birçok enflamatuvar hastalığın tedavisinde temel konumdayer alsa da beraberinde oluşan yan etkilerin de göz ardı edilmemesi gerektiğibir gerçektir.Sonyıllarda, enflamasyonla ilişkili moleküler temellerin ortaya konulmasıylabirlikte, enflamasyonun çözülme- sinin aktif ve agonist ilişkilibir süreç olduğu ve doku homeostazisine dönüşün çok dikkatli bir şekilde düzen-lendiği anlaşılmıştır. Enflamasyonun çözülmesinin yeni bir sınıf olan ileribasamak çözücü lipid medyatörleri (İBÇLM) tarafından düzenlendiğininanlaşılmasıyla birlikte, periodontal patolojinin önlenmesinde ve enfla- matuvarlökositlerin eliminasyonunda, İBÇLM molekül- lerinin potansiyel kullanımlarınaolan ilginin arttığı görülmektedir.Buderlemede, İBÇLM’lerin enflamatuvar süreçte ve periodontal hastalıkpatogenezindeki önemi ortaya konulmaya çalışılmıştır.Anahtar sözcükler: Periodontalhastalıklar, inflamasyon, yağ asidleriA NEW APPROACH IN PERIODONTAL TREATMENT: PRORESOLVING LIPID MEDIATORSABSTRACTComplete resolution of acute inflammatory response andreturning the body to homeostasis is crucial for on-going health. Althoughremoving of leukocytes in inflammation area without leaving any dead cells ortheir products behind is an ideal result, it appears that uncontrolled andunresolved inflammatory condition occurs in periodontal disease and varioussystemic diseases similarly.Most of the antiinflammatory agents studied up to nowsuch as steroids, non-steroid antiinflammatory drugs and antihistamines blokekey proinflammatory mediator ways in the initiation of acute inflammatoryresponse or take part in the control of the cardinal symptoms. Despite thistherapeutic approach is a basic principle for the treatment of many inflammatorydiseases, it’s clear that adverse effects should not be ignored. Recently, after the determination of the inflammatorybasics, we understood that inflammatory resolution is an active and agonistrelated process and returning to the tissue homeostasis is arranged verycarefully. Together with the understanding of the inflammatory resolution isarranged by new classification of proresolving lipid mediators (PRLMs), theinterest on these molecules related to the prevention of periodontal pathology andelimination of inflammatory leukocytes have increased.In this review, we aimed to put forward the importanceof the PRLMs on the inflammatory process and periodontal pathogenesis. Keywords: Periodontal diseases, inflammation, fatty acids

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