Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

1300-9044 2667-5161

Ataturk University

10.17567/ataunidfd.566916

Dentistry

Diş Hekimliği

PERİODONTAL ENFEKSİYONUN TEŞHİS VE PROGNOZUNDA UMUT VADEDEN BİYOBELİRTEÇLER

https://orcid.org/0000-0002-9496-9511

Şahin Ata

Özlem

https://orcid.org/0000-0002-7333-0524

Özkan

Yerda

https://orcid.org/0000-0003-4620-6437

Çanakçı

Cenk Fatih

07 15 2020

30 3 499 506 03 29 2019 10 20 2020

1986

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

ÖzPeriodontal hastalıklar çeşitlimikroorganizmalar tarafından başlatılmış olsa da, kompleks mikroflorası vekonak yanıtı periodontal durumu etkilemekte ve sipesifik hastalıkbelirteçlerini tanımlamayı zorlaştırmaktadır. Periodontal hastalık tanısındakullanılan sondalamada kanama, cep derinliği, klinik ataçman seviyesi veradyolojik kemik miktarı gibi klinik periodontal parametreler, hastalığınşiddetinin, prognozunun ve tedaviye verilen yanıtın değerlendirilmesindeyetersiz kalmaktadır. Bu nedenle, dişeti oluğu sıvısı, tükürük ve serumöneklerinde tespit edilebilen çeşitli biyobelirteçler bu konuda bize umut ışığıolmaktadır. Son dönemlerde, doku savunma hücreleri olan adipositlerden salınan veadipokinler olarak adlandırılan bazı proteinler rapor edilmiştir. Bu derlemede,çeşitli periodontal hastalıklarda çalışılmış adipokinler incelenmiş vegelecekte adipokinlerin bir biyobelirteç olarak periodontoloji alanındauygulanabilirliği tartışılmıştır.Anahtar Kelimeler: Adipokin, Yağ doku, Periodontalhastalık, biyobelirteçPROMISINGBIOMARKERS IN THE DIAGNOSIS AND PROGNOSIS OF PERIODONTAL INFECTIONAbstractAlthough periodontal disease isstarted by various bacteria, complex microflora and the host response affects periodontal condition and makes itdifficult to identify specific disease marker. Clinical parameters includingsuch as bleeding on probing, probing depth, clinical attachment level andradiographic bone amount which used in the diagnosis of periodontal disease,are insufficient to evaluate the severity and prognosis of disease and responseto treatment. Therefore,various biomarkers that can be detected in gingival fluid, saliva and serumsampels are the light of hope for us. Recently, some proteins, calledadipokines, which have been released from adipocytes as tissue defense cells,have been reported. In this review, adipokines studied in various periodontaldiseases are investigated and the applicability of adipokines as a biomarker inthe field of periodontology is discussed.Key Words: Adipokines,adipose tissue, periodontal disease, biomarkers

Adipokin Yağ doku Periodontal hastalık

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