DİŞ HEKİMLİĞİNDE OZON TEDAVİSİ

Year 2022, Volume: 32 Issue: 1, 100 - 107, 15.02.2022

Merve Sarı

https://doi.org/10.17567/ataunidfd.888905

Abstract

Ozon tedavisi uzun yıllardır tıp ve diş hekimliğinde uygulanmaktadır. Ozon antimikrobiyal, antihipoksik, immünomodülatör, biyosentetik ve analjezik gibi çeşitli etkilere sahiptir ve gittikçe kullanımı yaygınlaşmaktadır. Diş hekimliğinde yara iyileşmesi, diş çürüğü, oral liken planus, gingivitis ve periodontitis, çenenin osteonekrozu, postoperatif ağrı, plak ve biyofilmler, dentin hipersensitivitesi, temporomandibular eklem bozuklukları ve diş beyazlatma tedavisinde kullanılmaktadır. Bu çalışma ozonun mekanizmasını, uygulanma şekillerini ve çeşitli dental hastalıkların tedavisi için ozon kullanımını araştırmaktadır. Bu amaçla ozonun diş hekimliğinde çeşitli alanlarda kullanımına ilişkin kapsamlı bir literatür taraması yapılmıştır. Sonuç olarak ozon tedavisi diş hekimliğinin birçok alanında potansiyeli olan ve çeşitli dental hastalıkların tedavisine yönelik uygulanan minimal invaziv bir yaklaşım olduğu için oldukça umut vericidir.
Anahtar Kelimeler: ozon tedavisi; diş hekimliği; gingivitis ; periodontitis ; diş çürüğü; çene osteonekrozu; dentin hipersensitivitesi ; diş beyazlatma

OZONE THERAPY IN DENTISTRY
ABSTRACT
Ozone therapy has been used in medicine and dentistry for many years. Ozone has various effects such as antimicrobial, antihypoxic, immunomodulatory, biosynthetic and analgesic, and its use is becoming increasingly common. Ozone therapy has been used in dentistry for wound healing, dental caries, oral lichen planus, gingivitis and periodontitis, osteonecrosis of the jaw, postoperative pain, plaque and biofilm eliminations, dentin hypersensitivity, temporomandibular joint disorders and teeth whitening. This study investigates the mechanism of ozone, its application and its use for the treatment of various dental diseases. For this purpose, a comprehensive literature review has been made on the use of ozone in various fields of dentistry. As a result, ozone therapy is very promising as it is a minimally invasive approach that has potential in many areas of dentistry and is applied for the treatment of various dental diseases.
Keywords: ozone therapy; dentistry; gingivitis; periodontitis; dental caries; osteonecrosis of the jaw; dentin hypersensitivity; teeth whitening

Keywords

ozon tedavisi, gingivitis, periodontitis, diş çürüğü; çene osteonekrozu

References

• 1. Van Thoor J. Chemical Technology, An Encyclopedic Treatment, Vol. 1. Barnes and Noble, New York. 1968:393-400.
• 2. Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Archives of medical research. 2006;37(4):425-435.
• 3. Stopka P. Ozon. Progresdent. 2003;6:8-11.
• 4. Mollica P, Harris R. Integrating oxygen/ozone therapy into your practice.[Online].[Cited 2010 January 13];[4 screens].
• 5. Sujatha B, Kumar M, Pratap G, Vardhan R. Ozone therapy–A paradigm shift in dentistry. Health Sci. 2013;2(3):1-10.
• 6. Srikanth A, Sathish M, Harsha AVS. Application of ozone in the treatment of periodontal disease. Journal of pharmacy & bioallied sciences. 2013;5(Suppl 1):S89.
• 7. Meena A, Trivedi H, Gupta M, Parvez S, Likhyani L. Therapeutic applications of ozonated products. International Journal Of Dental Clinics. 2011;3(2).
• 8. Maiya A. Applications of ozone in dentistry. International Journal of Clinical Dental Science. 2011;2(3).
• 9. Makkar S, Makkar M. Ozone-Treating Dental Infections. Indian Journal of Stomatology. 2011;2(4).
• 10. Wilczyńska-Borawska M, Leszczyńska K, Nowosielski C, Stokowska W. Ozone in dentistry: microbiological effects of gas action depending on the method and the time of application using the ozonytron device. Experimental study. Paper presented at: Annales Academiae Medicae Stetinensis2011.
• 11. Komali G. Ozone Therapy-A revolutionary noninvasive therapy in dentistry. Open Access Scientific Reports. 2012;1(10):473.
• 12. Srinivasan SR, Amaechi BT. Ozone: A paradigm shift in dental therapy. Journal of Global Oral Health. 2019;2(1):68-77.
• 13. Bocci V. Ozone A new medical drug: Springer; 2005.
• 14. Estrela C, Estrela CR, Decurcio DdA, Silva JA, Bammann LL. Antimicrobial potential of ozone in an ultrasonic cleaning system against Staphylococcus aureus. Brazilian Dental Journal. 2006;17(2):134-138.
• 15. en Odontología O, Sistemática UR. Ozone therapy in dentistry: a systematic review. Int. J. Odontostomat. 2013;7(2):267-278.
• 16. Bocci VA, Zanardi I, Travagli V. Ozone acting on human blood yields a hormetic dose-response relationship. Journal of Translational Medicine. 2011;9(1):66.
• 17. González Muñoz L, Flichy Fernández A, Ata-Ali Mahmud FJ, Pascual Moscardó A, Peñarrocha Diago M. Effect of ozone therapy upon clinical and bacteriological parameters of the oral cavity: an update. 2011.
• 18. Moezizaden M. Future of dentistry, nanodentistry, ozone therapy and tissue engineering. J Dev Bio Tissue Eng. 2013;5:1-6.
• 19. Baysan A, Lynch E. The use of ozone in dentistry and medicine. Part 2. Ozone and root caries. Primary Dental Care. 2006;13(1):37-41.
• 20. Sawadaishi K, Miura K, Ohtsuka E, Ueda T, Ishizaki K, Shinriki N. Ozonolysis of supercoiled pBR322 DNA resulting in strand scission to open circular DNA. Nucleic acids research. 1985;13(20):7183-7194.
• 21. Mudd J, Leavitt R, Ongun A, McManus T. Reaction of ozone with amino acids and proteins. Atmospheric Environment (1967). 1969;3(6):669-681.
• 22. Roy D, Wong P, Engelbrecht R, Chian E. Mechanism of enteroviral inactivation by ozone. Appl. Environ. Microbiol. 1981;41(3):718-723.
• 23. Burleson GR, Murray T, Pollard M. Inactivation of viruses and bacteria by ozone, with and without sonication. Appl. Environ. Microbiol. 1975;29(3):340-344.
• 24. Katzenelson E, Koerner G, Biedermann N, Peleg M, Shuval H. Measurement of the inactivation kinetics of poliovirus by ozone in a fast-flow mixer. Appl. Environ. Microbiol. 1979;37(4):715-718.
• 25. Mudd JB, Dawson P, Santrock J. Ozone does not react with human erythrocyte membrane lipids. Archives of biochemistry and biophysics. 1997;341(2):251-258.
• 26. Bocci V. The case for oxygen-ozonetherapy. British journal of biomedical science. 2007;64(1):44-49.
• 27. Arsalane K, Gosset P, Vanhee D, et al. Ozone stimulates synthesis of inflammatory cytokines by alveolar macrophages in vitro. American journal of respiratory cell and molecular biology. 1995;13(1):60-68.
• 28. Van Hoof H, Zijlstra F, Voss H-P, et al. The effect of ozone exposure on the release of eicosanoids in guinea-pig BAL fluid in relation to cellular damage and inflammation. Mediators of inflammation. 1997;6(5-6):355-361.
• 29. Bayram H, Sapsford RJ, Abdelaziz MM, Khair OA. Effect of ozone and nitrogen dioxide on the release of proinflammatory mediators from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients in vitro. Journal of Allergy and Clinical Immunology. 2001;107(2):287-294.
• 30. Cho H-Y, Zhang L-Y, Kleeberger SR. Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-α receptors. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2001;280(3):L537-L546.
• 31. Maresca M, Colao C, Leoncini G. Generation of hydrogen peroxide in resting and activated platelets. Cell Biochemistry and Function: Cellular biochemistry and its modulation by active agents or disease. 1992;10(2):79-85.
• 32. Kumar A, Bhagawati S, Tyagi P, Kumar P. Current interpretations and scientific rationale of the ozone usage in dentistry: A systematic review of literature. European Journal of General Dentistry. 2014;3(3):175.
• 33. KORKMAZ DH, KÜÇÜKKOLBAŞI H. Diş Hekimliğinde ozon uygulamaları. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2013;23.
• 34. Suh Y, Patel S, Kaitlyn R, et al. Clinical utility of ozone therapy in dental and oral medicine. Medical gas research. 2019;9(3):163.
• 35. Pattanaik B, Jetwa D, Pattanaik S, Manglekar S, Naitam DN, Dani A. Ozone therapy in dentistry: a literature review. Journal of interdisciplinary dentistry. 2011;1(2):87.
• 36. Loesche WJ. Role of Streptococcus mutans in human dental decay. Microbiological reviews. 1986;50(4):353.
• 37. Huth K, Paschos E, Brand K, Hickel R. Effect of ozone on non-cavitated fissure carious lesions in permanent molars. A controlled prospective clinical study. American journal of dentistry. 2005;18(4):223-228.
• 38. Baysan A, Whiley R, Lynch E. Antimicrobial effect of a novel ozone–generating device on micro–organisms associated with primary root carious lesions in vitro. Caries Research. 2000;34(6):498-501.
• 39. Baysan A, Lynch E. The use of ozone in dentistry and medicine. Primary Dental Care. 2005(2):47-52.
• 40. Polydorou O, Pelz K, Hahn P. Antibacterial effect of an ozone device and its comparison with two dentin‐bonding systems. European journal of oral sciences. 2006;114(4):349-353.
• 41. Knight G, McIntyre J, Craig G, Zilm P. The inability of Streptococcus mutans and Lactobacillus acidophilus to form a biofilm in vitro on dentine pretreated with ozone. Australian dental journal. 2008;53(4):349-353.
• 42. Baysan A, Beighton D. Assessment of the ozone-mediated killing of bacteria in infected dentine associated with non-cavitated occlusal carious lesions. Caries research. 2007;41(5):337-341.
• 43. Baysan A, Lynch E. Effect of ozone on the oral microbiota and clinical severity of primary root caries. American journal of dentistry. 2004;17(1):56-60.
• 44. Johansson E, Claesson R, Van Dijken J. Antibacterial effect of ozone on cariogenic bacterial species. Journal of dentistry. 2009;37(6):449-453.
• 45. Magni E, Hickel R, Ilie N. Influence of gasiform ozone on the micromechanical properties of dentin. Int Dent SA. 2009;5:16-21.
• 46. Dähnhardt JE, Jäggi T, Lussi A. Treating open carious lesions in anxious children with ozone. A prospective controlled clinical study. American journal of dentistry. 2006;19(5):267-270.
• 47. Brazzelli M, McKenzie L, Fielding S, et al. Systematic review of the effectiveness and cost-effectiveness of Healozone for the treatment of occlusal pit/fissure caries and root caries. 2006.
• 48. Sechi LA, Lezcano I, Nunez N, et al. Antibacterial activity of ozonized sunflower oil (Oleozon). Journal of applied microbiology. 2001;90(2):279-284.
• 49. Nagayoshi M, Kitamura C, Fukuizumi T, Nishihara T, Terashita M. Antimicrobial effect of ozonated water on bacteria invading dentinal tubules. Journal of Endodontics. 2004;30(11):778-781.
• 50. Huth KC, Quirling M, Maier S, et al. Effectiveness of ozone against endodontopathogenic microorganisms in a root canal biofilm model. International Endodontic Journal. 2009;42(1):3-13.
• 51. Velano H, Panzeri H. In vitro assessment of antibacterial activity of ozonized water against Staphylococcus aureus. Pesquisa odontologica brasileira= Brazilian oral research. 2001;15(1):18-22.
• 52. Hems R, Gulabivala K, Ng YL, Ready D, Spratt D. An in vitro evaluation of the ability of ozone to kill a strain of Enterococcus faecalis. International Endodontic Journal. 2005;38(1):22-29.
• 53. Cardoso MG, de Oliveira LD, Koga-Ito CY, Jorge AOC. Effectiveness of ozonated water on Candida albicans, Enterococcus faecalis, and endotoxins in root canals. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2008;105(3):e85-e91.
• 54. Kist S, Kollmuss M, Jung J, Schubert S, Hickel R, Huth KC. Comparison of ozone gas and sodium hypochlorite/chlorhexidine two-visit disinfection protocols in treating apical periodontitis: a randomized controlled clinical trial. Clinical oral investigations. 2017;21(4):995-1005.
• 55. Noites R, Pina-Vaz C, Rocha R, Carvalho MF, Gonçalves A, Pina-vaz I. Synergistic antimicrobial action of chlorhexidine and ozone in endodontic treatment. BioMed research international. 2014;2014.
• 56. Estrela C, Estrela C, Decurcio D, Hollanda A, Silva J. Antimicrobial efficacy of ozonated water, gaseous ozone, sodium hypochlorite and chlorhexidine in infected human root canals. International Endodontic Journal. 2007;40(2):85-93.
• 57. Boch T, Tennert C, Vach K, Al-Ahmad A, Hellwig E, Polydorou O. Effect of gaseous ozone on Enterococcus faecalis biofilm–an in vitro study. Clinical oral investigations. 2016;20(7):1733-1739.
• 58. Lynch E, Holmes J, Johnson D, Grootveld M, Baysen A. Integration into General Dental Practice. Successful treatment of caries using Heal Ozone. Dent Horiz. 2004;2:23-27.
• 59. MI R, Gomaa H, MI M, Zaki B. Management of aggressive periodontitis using ozonized water. Egypt Med JNR C. 2005;6(1):229-245.
• 60. Nagayoshi M, Fukuizumi T, Kitamura C, Yano J, Terashita M, Nishihara T. Efficacy of ozone on survival and permeability of oral microorganisms. Oral microbiology and immunology. 2004;19(4):240-246.
• 61. Baysan A. Management of primary root caries using ozone therapies. London: University of London. 2002.
• 62. Unal M, Oztas N. Remineralization capacity of three fissure sealants with and without gaseous ozone on non-cavitated incipient pit and fissure caries. Journal of Clinical Pediatric Dentistry. 2015;39(4):364-370.
• 63. Huth KC, Quirling M, Lenzke S, et al. Effectiveness of ozone against periodontal pathogenic microorganisms. European journal of oral sciences. 2011;119(3):204-210.
• 64. Skurska A, Pietruska M, Paniczko-Drężek A, et al. Evaluation of the influence of ozonotherapy on the clinical parameters and MMP levels in patients with chronic and aggressive periodontitis. Advances in medical sciences. 2010;55(2):297-307.
• 65. Al Habashneh R, Alsalman W, Khader Y. Ozone as an adjunct to conventional nonsurgical therapy in chronic periodontitis: a randomized controlled clinical trial. Journal of periodontal research. 2015;50(1):37-43.
• 66. Ebensberger U, Pohl Y, Filippi A. PCNA‐expression of cementoblasts and fibroblasts on the root surface after extraoral rinsing for decontamination. Dental Traumatology. 2002;18(5):262-266.
• 67. Taşdemir Z, Alkan BA, Albayrak H. Effects of ozone therapy on the early healing period of deepithelialized gingival grafts: a randomized placebo‐controlled clinical trial. Journal of periodontology. 2016;87(6):663-671.
• 68. Saini R. Ozone therapy in dentistry: A strategic review. Journal of natural science, biology, and medicine. 2011;2(2):151.
• 69. Karapetian VE, Neugebauer J, Clausnitzer CE, Zoller J. Comparison of different periimplantitis treatment methods. Paper presented at: Posterpresentation 19th Annual Meeting Academy of Osseointegration March2004.
• 70. Low SP, Williams KA, Canham LT, Voelcker NH. Generation of reactive oxygen species from porous silicon microparticles in cell culture medium. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials. 2010;93(3):1124-1131.
• 71. Low SP, Williams KA, Canham LT, Voelcker NH. Evaluation of mammalian cell adhesion on surface-modified porous silicon. Biomaterials. 2006;27(26):4538-4546.
• 72. Rolán DV, Lopez MM, Cuberas-Borrós G, et al. Neurological symptoms following exposure to ozone. Journal of neurology. 2012;259(12):2740-2742.
• 73. Arita M, Nagayoshi M, Fukuizumi T, et al. Microbicidal efficacy of ozonated water against Candida albicans adhering to acrylic denture plates. Oral microbiology and immunology. 2005;20(4):206-210.
• 74. Oizumi M, Suzuki T, Uchida M, Furuya J, Okamoto Y. In vitro testing of a denture cleaning method using ozone. Journal of medical and dental sciences. 1998;45(2):135-139.
• 75. Nogales CG, Ferrari PH, Kantorovich EO, Lage-Marques J. Ozone therapy in medicine and dentistry. J Contemp Dent Pract. 2008;9(4):75-84.
• 76. Bocci V, Luzzi E, Corradeschi F, Silvestri S. Studies on the biological effects of ozone: 6. Production of transforming growth factor 1 by human blood after ozone treatment. Journal of biological regulators and homeostatic agents. 1994;8(4):108-112.
• 77. Loncar B, Stipetic MM, Matosevic D, Tarle Z. Ozone application in dentistry. Archives of medical research. 2009;40(2):136-137.
• 78. Ahmedi J, Ahmedi E, Sejfija O, Agani Z, Hamiti V. Efficiency of gaseous ozone in reducing the development of dry socket following surgical third molar extraction. European journal of dentistry. 2016;10(03):381-385.
• 79. Bhardwaj N, Angadi P. OZONE THERAPY IN DENTISTRY.
• 80. Reddy S, Reddy N, Dinapadu S, Reddy M, Pasari S. Role of ozone therapy in minimal intervention dentistry and endodontics-A review. Journal of international oral health: JIOH. 2013;5(3):102.
• 81. Petrucci MT, Gallucci C, Agrillo A, Mustazza MC, Fo R. Role of ozone therapy in the treatment of osteonecrosis of the jaws in multiple myeloma patients. Haematologica. 2007;92(9):1289-1290.
• 82. Ripamonti CI, Maniezzo M, Pessi MA, Boldini S. Treatment of osteonecrosis of the jaw (ONJ) by medical ozone gas insufflation. A case report. Tumori Journal. 2012;98(3):e72-e75.
• 83. Daif ET. Role of intra-articular ozone gas injection in the management of internal derangement of the temporomandibular joint. Oral surgery, oral medicine, oral pathology and oral radiology. 2012;113(6):e10-e14.
• 84. Doğan M, Doğan DÖ, Düger C, et al. Effects of high-frequency bio-oxidative ozone therapy in temporomandibular disorder-related pain. Medical Principles and Practice. 2014;23(6):507-510.
• 85. Azarpazhooh A, Limeback H, Lawrence HP, Fillery ED. Evaluating the effect of an ozone delivery system on the reversal of dentin hypersensitivity: a randomized, double-blinded clinical trial. Journal of endodontics. 2009;35(1):1-9.
• 86. Özgül BM, Saat S, Sönmez H, Öz FT. Clinical evaluation of desensitizing treatment for incisor teeth affected by molar-incisor hypomineralization. Journal of Clinical Pediatric Dentistry. 2013;38(2):101-105.
• 87. Raafat Abdelaziz R, Mosallam RS, Yousry MM. Tubular occlusion of simulated hypersensitive dentin by the combined use of ozone and desensitizing agents. Acta Odontologica Scandinavica. 2011;69(6):395-400.
• 88. Tessier J, Rodriguez PN, Lifshitz F, Friedman SM, Lanata EJ. The use of ozone to lighten teeth: An experimental study. Acta odontologica latinoamericana. 2010;23(2):84-89.
• 89. Szymańska J. Evaluation of mycological contamination of dental unit waterlines. Annals of agricultural and environmental medicine: AAEM. 2005;12(1):153-155.
• 90. Menzel DB. Ozone: an overview of its toxicity in man and animals. 1984.
• 91. Gopalakrishnan S, Parthiban S. Ozone-a new revolution in dentistry. J Bio Innov. 2012;1(3):58-69.
• 92. Almaz ME, Sönmez IŞ. Ozone therapy in the management and prevention of caries. Journal of the formosan medical association. 2015;114(1):3-11.
• 93. Gupta G, Mansi B. Ozone therapy in periodontics. Journal of medicine and life. 2012;5(1):59.
• 94. Burke FT. Ozone and caries: a review of the literature. Dental update. 2012;39(4):271-278.