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Noradrenalinin, İn Vitro Koşullar Altında Besi Hindilerinde İnce ve Kalın Bağırsak Düz Kasları Üzerine Etkisi

Year 2018, Volume: 13 Issue: 3, 257 - 265, 25.12.2018
https://doi.org/10.17094/ataunivbd.349019

Abstract

Bu çalışmanın amacı heavy hybrid hindilerin ince ve kalın bağırsaklarındaki düz kaslarda bulunan adrenerjik reseptörlerin olası varlığını in vitro koşullar altında farklı konsantrasyonlarda non-selektif adrenerjik reseptör agonisti, noradrenalin, kullanarak belirlemektir. Çalışma 24 besi hindisinde gerçekleştirildi. Organ izolasyon cihazında duodenum, jejunum, ileum, çekum ve kolonun müsküler longitudinal ve sirküler tabakalarında testler farklı konsantrasyonlarda noradrenalin hydrogentartarate solüsyonu kullanılarak test edildi. Çalışma besi hindilerinin ince ve kalın bağırsaklarındaki düz kaslarda bulunan adrenerjik reseptörlerin olası varlığını ortaya koymdu. Noradrenalin’in longitudinal tabaka üzerindeki etkisi, besi hindilerinin ince ve kalın bağırsaklarında ki tunica muscularis sirküler tabaka üzerinde ki etkisinden daha güçlüydü (P<0.001). Farklı konsantrasyonlarda noradrenalin kullanımına ilişkin olarak elde edilen sonuçlarda da istatistiksel olarak anlamlı farklılıklar vardı. Noradrenalinin ince ve kalın bağırsakların farklı bölgelerindeki etkilerinde de önemli farklılıklar bulundu. Selektif agonistler ve α ve β reseptör antagonistleri kullanılarak, besi hindilerinin ince ve kalın bağırsak düz kaslarında daha fazla araştırma yapılması gerekmektedir.

References

  • 1. Ćupić V., Muminović M., Kobal S., Velev R., 2014. Textbook of Veterinary Pharmacology. Belgrade, Sarajevo, Ljubljana, Skopje, 2nd edn., p. 291-294, 304-305, National Library of Serbia, Belgrade.
  • 2. Gvozdić D. Pathophysiology of Endocrinology System. In.: Božić T., Textbook of Pathophysiology of domestic animals. 2nd edn., 2012. p. 394-396, Mladost Biro d.o.o., Belgrade, Serbia.
  • 3. Hodžić A., Hamamdžić M., 2012. Endocrinology of domestic animals. p. 80-97, University textbook, Sarajevo, Bosnia and Herzegovina.
  • 4. Mujezinović I., 2007. The impact of physiological and pharmacological active substances and their antagonists in the small intestine smooth muscle of broilers. University of Sarajevo, Veterinary Faculty, Bosnia and Herzegovina.
  • 5. Guyton AC., Hall JE., 2003. Textbook of Medical Physiology. 10th edn., p. 408-418, Medicinska naklada, Zagreb, Croatia.
  • 6. Bylund, DB., Eikenberg DC., Hieble JP., Langer SZ., Lefkowitz R.J., Minneman K.P., Molinoff P.B., Ruffolo RR., Trendelenburg AU, 1994. IV. International Union of Pharmacology Nomenclature of Adrenoceptors. Pharmacol. Rev., 46, 121–136.
  • 7. Katica M., Katica A., Mlaćo N, 2016. The role of catecholamines in maintenance of homeostasis in digestive tract of domestic animals. Atatürk University Journal of Veterinary Sciences., 11, 106-111.
  • 8. Muminović M., 1991. The effects of physiological and pharmacological active substances and some of their antagonists in the rumen of cattle in order to improve pharmacotherapy. University of Sarajevo, Veterinary Faculty, Bosnia and Herzegovina.
  • 9. Katica M., 2015a. Testing the effects of physiologically and pharmacologically active substances and their antagonists in smooth intestine musculature during the turkey fattening phase. University of Sarajevo, Veterinary Faculty, Bosnia and Herzegovina.
  • 10. Katica M., 2015b. Presence of adrenergic recptors in the wall of caecum during Turkey Fattening Phase. International Congress, One World-One Health-One Vision, Book of Abstracts, p. 113- 115, Sarajevo, Bosnia and Herzegovina.
  • 11. Bylund, D. B., 2005. Alpha-2 adrenoceptor subtypes: are more better? British Journal of Pharmacology, 144, 159–160.
  • 12. Minitab Inc., 2003. Minitab Statistical Software. Release 14 for Windows, State College, Pennsylvania.
  • 13. MA PM., 1997. Catecholaminergic systems in the zebrafish. III Organization and projection pattern of medullary dopaminergic and noradrenergic neurons. J. Comp. Neurol., 381, 411–427.
  • 14. Manara L., Croci T., Aureggi G., Guagnini F., MaVrand JP., Le Fur G., Mukenge S., Ferla G., 2000. Functional assessment of adrenoceptor subtypes in huma colonic circular and longitudinal (taenia coli) smooth muscle. Gut, 47, 337-342, 129. 15. De Ponti F., Giaroni C., Cosentino M., Lesshini S., Frigo G., 1996. Adrenergic mechanism in the control of gastrointestinal motility: From basic science to clinical application. Pharmacology Therapeutics, 69, 1, 59-78.

Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions

Year 2018, Volume: 13 Issue: 3, 257 - 265, 25.12.2018
https://doi.org/10.17094/ataunivbd.349019

Abstract

The aim of the study was to determine the possible presence of adrenergic receptors in the smooth musculature of small and large intestines of heavy hybrid turkey, using different concentrations of non-selective adrenergic receptor agonists, noradrenaline, under in vitro conditions. The research was carried out on 24 fattening turkeys. Tests of circular and longitudinal layers of muscular duodenum, jejunum, ileum, cecum and colon in the organ isolation apparatus, using different concentrations of noradrenaline hydrogentartarate solution, were tested. The research has established the presence of adrenergic receptors within the smooth musculature of the small and large intestines of fattening turkeys. The effect of the noradrenaline on the longitudinal layer was stronger (P<0.001) than the effect on the circular layer of tunica muscularis in small and large intestines of fattening turkeys. There were also statistically significant differences in the results obtained with regard to the use of different concentrations of noradrenaline. Significant differences in the effects of noradrenaline in different parts of the small and large intestines have also been established. Further research into smooth musculature of the small and large intestines of fattening turkeys is needed, with the use of selective agonists and α and β receptor antagonists.

References

  • 1. Ćupić V., Muminović M., Kobal S., Velev R., 2014. Textbook of Veterinary Pharmacology. Belgrade, Sarajevo, Ljubljana, Skopje, 2nd edn., p. 291-294, 304-305, National Library of Serbia, Belgrade.
  • 2. Gvozdić D. Pathophysiology of Endocrinology System. In.: Božić T., Textbook of Pathophysiology of domestic animals. 2nd edn., 2012. p. 394-396, Mladost Biro d.o.o., Belgrade, Serbia.
  • 3. Hodžić A., Hamamdžić M., 2012. Endocrinology of domestic animals. p. 80-97, University textbook, Sarajevo, Bosnia and Herzegovina.
  • 4. Mujezinović I., 2007. The impact of physiological and pharmacological active substances and their antagonists in the small intestine smooth muscle of broilers. University of Sarajevo, Veterinary Faculty, Bosnia and Herzegovina.
  • 5. Guyton AC., Hall JE., 2003. Textbook of Medical Physiology. 10th edn., p. 408-418, Medicinska naklada, Zagreb, Croatia.
  • 6. Bylund, DB., Eikenberg DC., Hieble JP., Langer SZ., Lefkowitz R.J., Minneman K.P., Molinoff P.B., Ruffolo RR., Trendelenburg AU, 1994. IV. International Union of Pharmacology Nomenclature of Adrenoceptors. Pharmacol. Rev., 46, 121–136.
  • 7. Katica M., Katica A., Mlaćo N, 2016. The role of catecholamines in maintenance of homeostasis in digestive tract of domestic animals. Atatürk University Journal of Veterinary Sciences., 11, 106-111.
  • 8. Muminović M., 1991. The effects of physiological and pharmacological active substances and some of their antagonists in the rumen of cattle in order to improve pharmacotherapy. University of Sarajevo, Veterinary Faculty, Bosnia and Herzegovina.
  • 9. Katica M., 2015a. Testing the effects of physiologically and pharmacologically active substances and their antagonists in smooth intestine musculature during the turkey fattening phase. University of Sarajevo, Veterinary Faculty, Bosnia and Herzegovina.
  • 10. Katica M., 2015b. Presence of adrenergic recptors in the wall of caecum during Turkey Fattening Phase. International Congress, One World-One Health-One Vision, Book of Abstracts, p. 113- 115, Sarajevo, Bosnia and Herzegovina.
  • 11. Bylund, D. B., 2005. Alpha-2 adrenoceptor subtypes: are more better? British Journal of Pharmacology, 144, 159–160.
  • 12. Minitab Inc., 2003. Minitab Statistical Software. Release 14 for Windows, State College, Pennsylvania.
  • 13. MA PM., 1997. Catecholaminergic systems in the zebrafish. III Organization and projection pattern of medullary dopaminergic and noradrenergic neurons. J. Comp. Neurol., 381, 411–427.
  • 14. Manara L., Croci T., Aureggi G., Guagnini F., MaVrand JP., Le Fur G., Mukenge S., Ferla G., 2000. Functional assessment of adrenoceptor subtypes in huma colonic circular and longitudinal (taenia coli) smooth muscle. Gut, 47, 337-342, 129. 15. De Ponti F., Giaroni C., Cosentino M., Lesshini S., Frigo G., 1996. Adrenergic mechanism in the control of gastrointestinal motility: From basic science to clinical application. Pharmacology Therapeutics, 69, 1, 59-78.
There are 14 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Araştırma Makaleleri
Authors

Muhamed Katica

Indira Mujezinović

Nedžad Gradaščević This is me

Publication Date December 25, 2018
Published in Issue Year 2018 Volume: 13 Issue: 3

Cite

APA Katica, M., Mujezinović, I., & Gradaščević, N. (2018). Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 13(3), 257-265. https://doi.org/10.17094/ataunivbd.349019
AMA Katica M, Mujezinović I, Gradaščević N. Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. December 2018;13(3):257-265. doi:10.17094/ataunivbd.349019
Chicago Katica, Muhamed, Indira Mujezinović, and Nedžad Gradaščević. “Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 13, no. 3 (December 2018): 257-65. https://doi.org/10.17094/ataunivbd.349019.
EndNote Katica M, Mujezinović I, Gradaščević N (December 1, 2018) Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 13 3 257–265.
IEEE M. Katica, I. Mujezinović, and N. Gradaščević, “Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions”, Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 13, no. 3, pp. 257–265, 2018, doi: 10.17094/ataunivbd.349019.
ISNAD Katica, Muhamed et al. “Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi 13/3 (December 2018), 257-265. https://doi.org/10.17094/ataunivbd.349019.
JAMA Katica M, Mujezinović I, Gradaščević N. Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2018;13:257–265.
MLA Katica, Muhamed et al. “Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions”. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, vol. 13, no. 3, 2018, pp. 257-65, doi:10.17094/ataunivbd.349019.
Vancouver Katica M, Mujezinović I, Gradaščević N. Effects of Noradrenaline on Smooth Musculature of Small and Large Intestines of Fattening Turkey Under In Vitro Conditions. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2018;13(3):257-65.