Assessment of Hepatotoxic Effects of Quetiapıne at Repeated Doses in Rats

Year 2018, Volume: 7 Issue: 2, 196 - 206, 17.08.2018

SİNEM Ilgın DİLEK Burukoğlu MERVE Baysal ÖZLEM Hinis ÖZLEM Atlı

https://doi.org/10.18036/aubtdc.349864

Cited By: 1

Abstract

Quetiapine
is an atypical antipsychotic drug used for treatments of patients with
schizophrenia. Although hepatotoxic effects related to quetiapine treatment
were reported in a few studies, potential hepatotoxicity of this drug was not
identified clearly. Therefore, it was aimed to evaluate possible hepatotoxic
effects of quetiapine by oral administration of this drug at 10 and 20 mg/kg
doses to rats for 30 days in our study. For this purpose, plasma aspartate
aminotransferase, alanine aminotransferase, total bilirubin and direct
bilirubin levels as markers of hepatotoxicity were determined and
histopathological examination was performed in liver tissues. According to our
results, serum aspartate aminotransferase and alanine aminotransferase levels
were significantly increased in quetiapine-administered groups, whereas total
and direct bilirubin levels were significantly increased in high dose group.
Histopathological examination of liver tissue indicated that necrotic areas
were observed in 10 mg/kg quetiapine-administered group whereas necrotic areas
were present and sinusoidal dilatation was observed in 20 mg/kg
quetiapine-administered group. According to these results, we concluded that
quetiapine may induced hepatotoxic effects in rats, dose-dependently.

Keywords

Quetiapine, hepatotoxicity, hepatic biomarkers, oxidative stress

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