Research Article
Year 2018,
Volume: 7 Issue: 2, 220 - 226, 17.08.2018
Abstract
References
- Referans 1. Howell S, Shalet S. Gonadal damage from chemotherapy and radiotherapy. Endocrinol. Metab. Clin. North. Am 1998; 27: 927–4.3
- Referans 2. Kayaalp O. Vitaminler, E vitamini, Rasyonel tedavi yönünden tıbbi farmakoloji. 1.baskı. Ankara Türkiye: Hacettepe-Taş Kitapçılık, 2009.
- Referans 3.Meistrich ML, Wilson G, Kangasniemi M. Mechanism of protection of rat spermatogenesis by hormonal pretreatment: stimulation of spermatogonyum l differentiation after irradiation. Journal of Andrology 2000; Vol 2.
- Referans 4. Papageorgio C, McLeod HL Chemoterapy: Principles and Pharmacology. The Washington Manual of Oncology Philadelphia , Lippincott , Williams-Wilkins, 2002.
- Referans 5. Estakhri R, Hajipour B, Majidi H , Soleimani H. Vitamin E ameliorates cyclophosphamide induced nephrotoxicity. Life Science Journal 2013;10:6.
- Referans 6. Nagel E, zu Vilsendorf AM, Bartels M, Pichlmayr R. Antioxidative vitamins in prevention of ischemia/reperfusion injury. Internat J Vit Nutr Res 1997; 67: 298-306.
- Referans 7. Lamirande E, Gagnon C. Reactive oxygen species and human spermatozoa II. Depletion of adenosine triphosphate plays an important role in the inhibition of sperm motility. J Androl 1992; 13: 379-386.
- Referans 8. Palamanda JR, Kehrer JR. Involvement of vitamin E and protein thiols in the inhibition of microsomal lipid peroxidation by glutathione.Lipids 1993; 28:427-431.
- Referans 9. Sarkar SD, Maiti R, Ghosh D. Management of fluoride induced testicular disorders by calcium and Vitamin-E co-administration in the albino rat, Reproductive Toxicology 2006; 22: 606-612.
- Referans 10. Chapman RM. Gonadal injury resulting from chemotherapy. Am J Indust Med 1983; 4:149-161.
- Referans 11. Rezvanfar MA, Sadrkhanlou RA, Ahmadi A, Shojaei-Sadee H. Protection of cyclophosphamide-induced toxicity in reproductive tract histology, sperm characteristics, and DNA damage by an herbal source; evidence for role of free-radical toxic stres. Hum Exp Toxicol 2008; 27, 901.
- 12. Laila M.E. Sabik, Sahar S.Abd.El-Rahman. Alpha-tocopherol and ginger are protective on cyclophosphamide-induced gonadal toxicity in adult male albino rats. Basic and Applied Pathology 2009; 2: 21-29
HISTOLOGICAL EXAMINATION OF THE ROLE OF VITAMIN E IN CYCLOPHOSPHAMIDE-INDUCED TESTICULAR DAMAGE IN RATS
Abstract
Cyclophosphamide is among
anticancer and immunosuppressing drugs frequently used in chemotherapy
treatment. Cyclophosphamide
is a chemotherapeutic agent but has also toxic effect on testes. Testicular cells
can be protected from toxic effects by antioxidant systems, including vitamin E.
The aim of this study is to reveal what kind of an
effect the vit-E exerts upon the experimentally induced CP toxicity on testicular
tissue of rats. Results
of the present study indicate that the testicular injury induced by CP can be
prevented by administration of vitamin E.
Keywords
References
- Referans 1. Howell S, Shalet S. Gonadal damage from chemotherapy and radiotherapy. Endocrinol. Metab. Clin. North. Am 1998; 27: 927–4.3
- Referans 2. Kayaalp O. Vitaminler, E vitamini, Rasyonel tedavi yönünden tıbbi farmakoloji. 1.baskı. Ankara Türkiye: Hacettepe-Taş Kitapçılık, 2009.
- Referans 3.Meistrich ML, Wilson G, Kangasniemi M. Mechanism of protection of rat spermatogenesis by hormonal pretreatment: stimulation of spermatogonyum l differentiation after irradiation. Journal of Andrology 2000; Vol 2.
- Referans 4. Papageorgio C, McLeod HL Chemoterapy: Principles and Pharmacology. The Washington Manual of Oncology Philadelphia , Lippincott , Williams-Wilkins, 2002.
- Referans 5. Estakhri R, Hajipour B, Majidi H , Soleimani H. Vitamin E ameliorates cyclophosphamide induced nephrotoxicity. Life Science Journal 2013;10:6.
- Referans 6. Nagel E, zu Vilsendorf AM, Bartels M, Pichlmayr R. Antioxidative vitamins in prevention of ischemia/reperfusion injury. Internat J Vit Nutr Res 1997; 67: 298-306.
- Referans 7. Lamirande E, Gagnon C. Reactive oxygen species and human spermatozoa II. Depletion of adenosine triphosphate plays an important role in the inhibition of sperm motility. J Androl 1992; 13: 379-386.
- Referans 8. Palamanda JR, Kehrer JR. Involvement of vitamin E and protein thiols in the inhibition of microsomal lipid peroxidation by glutathione.Lipids 1993; 28:427-431.
- Referans 9. Sarkar SD, Maiti R, Ghosh D. Management of fluoride induced testicular disorders by calcium and Vitamin-E co-administration in the albino rat, Reproductive Toxicology 2006; 22: 606-612.
- Referans 10. Chapman RM. Gonadal injury resulting from chemotherapy. Am J Indust Med 1983; 4:149-161.
- Referans 11. Rezvanfar MA, Sadrkhanlou RA, Ahmadi A, Shojaei-Sadee H. Protection of cyclophosphamide-induced toxicity in reproductive tract histology, sperm characteristics, and DNA damage by an herbal source; evidence for role of free-radical toxic stres. Hum Exp Toxicol 2008; 27, 901.
- 12. Laila M.E. Sabik, Sahar S.Abd.El-Rahman. Alpha-tocopherol and ginger are protective on cyclophosphamide-induced gonadal toxicity in adult male albino rats. Basic and Applied Pathology 2009; 2: 21-29
There are 12 citations in total.
Details
| Primary Language | English |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | August 17, 2018 |
| Published in Issue | Year 2018 Volume: 7 Issue: 2 |
