Ankara Üniversitesi Tıp Fakültesi Mecmuası

0365-8104 1307-5608

Ankara University

Gastroenterology and Hepatology

Gastroenteroloji ve Hepatoloji

Circulating Immune Complexes in Colytic Ulcerosis

Kolitik Ulserozada Dolaşan İmmün Kompleksler

Dökmeci

Kadir

Ankara Üniversitesi Tıp Fak, Gastroenteroloji Bilim Dalı

03 31 1987

40 1 1 8 01 01 1987 03 31 1987

1947

Ankara Üniversitesi Tıp Fakültesi Mecmuası

We have studied the level of circulating immun complex, immunglobulins and complemans in order to evaluate the role of these factors on the pathogenesis of ulcerative colitis. We determined the level of circulating immun complex, immunglobulins and complemans in 24 patients with ulcerative colitis and 11 healthy controls. We have found that circulating immun complex were higher than normal in five among seven patients without therapy ( % 71) though 10 among that immunologic changes in ulcerative colitis either, primary factor or occured as secondary results

Kolitis ülseroza etyopatogenezinde dolaşan immun kompleksler, immunglobulin ve komplemanların seviyelerini araştırmak maksadıyla bu çalışmamızı yaptık, On bir sağlıklı kişiden oluşan kontrol grubu ile 24 kolitis ülserozall hastada dolaşan immun kompleks, ve immunglobulin ve kompleman serum düzeyleri tayin edildi. Tedavi almıyan 7 hastanın 5 inde 71.42) dolaşan immun kompleksleri yük sek bulunmasına karşılık immunosupressif tedavi altında olan 17 has tanın 10 unda 58.82) tesbit edilmiştir. Bu sonuçlar ışığında koljtjs ülserozada tesbit edilen immunopatoloji etyopatogenezde primer faktörmüdür yoksa sekonder olartzk mı husule gelmektedir. Bu gün tam olarak bilinmemektedir.

immun immunglobulins compleman pathogenesis

bağışıklık immünoglobülin tamamlayıcı patogenez

1. Ballard J.. Shinee : Evidenece of Cytotoxicity in Ulserative Colitis from Immunofluorescent staining or the rectal mucosa, The Lancet may 25 (2) 1014-1017. 1974

2. Becker W Schwick H.G. und Störiko K. : Methoth for qvantitative Datermia• tion of plasma proteins By Immunoprecipitation Z Klin. Chem. Klin. Biochez. : 113-112, 1986.

3. Digeon NL, Laver M.. Rua J. and Bach M.J.F. Journal of Immunolojical Methods 16 165-163, 1977.

4. Elmgreen J. Berkowicz A., Sorensen H, : Defective Relase of C5a Related Chema-attractant Activity From Compleman in Crohn's. Disease. Gut 24 525-531, 1923.

5. Fiocchi Youngman R.K., Farmer G.R. : Lmmunoregulatory Function of Human intestinal Mucosa Lymphoid Cells : Evidence for Enhanced Supressor Cell activity in inflamnatory Bowel Disease, Gut 24 692-701, 1993.

6. Ginsburg HC et all. : Impaired Natural Killer Cell Activity in patients with inflammatory Bowel Disease Evindonce for a gualitative defect. Gastroenterology 05 846-850, 1903.

7. Godin J.N., Sachar BD. Winchester et al. Loss of Supressor T cell in Active Inflammatory Bowel Disease. Gut 25 : 745-747. 1984,

8. Heatley V.R. et. all* Pulmonary Function Abnormalities in patients with inflammatory Bowel Diseas. Quarterly Journal of Medicine New Series L 203 : 241250, 1982.

9. Higgenes S.C., Kaighley B.R.M., Allan N.R.i Immpact of Preoperative weigh(Loss and Body Compostion changes on posterative Qutcome in Surgery for inflamrnatory Bowel Disease. Gut 23 : 732-736. 1984.

10. Hod gson F.J.H., Potter J.B., Jewell PD., Immun Complexes in Ulcerative colitis and Crohn's Disease. Clin. Exp. Immunol. 29 187-196, 1977.

11. Hodgson F.J.H. Jewell BD., Humoral Immune System in inflammatory Bowel Disease : 1. Compleman level. Gut 1B : 749-753. 1977.

12, Hodgson F,J.H., Potter JB., Jewell PD. C3 metabolsm n Ulceratvie Colitis and and Crohn's Diseasi, Clin Exp. Immunol. : 490-495. 1977.

13. Hodg son F.J.H. et al. Immune Complex Mediated Colitis in Rabbits. Gut 19 225-232, 1977.

14, Jewel PD. Circulating Immune CompleKes in Inflammatory Bowel Disease Clin.Exp. Immunol 14 219-226. 1973.

15. Lawley J.T., James P.S., Jones A.E. Circulating Immune Comploxo ; There Deto citon and potential Significanceg. In some Hepatobiliaary and Intestinal Disease. Gastroenterology 78 626-641, 1930.

16. Learmonth P.R., Immune Complexe in Ulcerative Colitis. Digestive and Sciences 29 4-14, 1984.

17. Mmc Dermott P.C. Beagdon J.M., Thurmond DR. Periphneral Blood Mononuclear cellsfrom Patients With Inflamatory Bowel Disease. Exhibit normal Function in The Allogenoic and Autologcus Mixed LeUkocyte Reaction and cell Mediated Lympholysis, Gastroenterology 86 : 476-483. 1984.

18. Mancini, GA O. Carbonaro and J.F. Heremans Immunochemistry 2 295, 1965.

19. Monterio E., Fogsey J. Shiner M. Antibacterial Antibodies in Ractal and Colonic Mucosa in Ulcerative Colitis. The lancet 6 ; 249-251, 1971.

20. Nielson H, Binder V. Daugharty H.. Circulating Immune Complexe in Ulcerative Colitis. Clin. Exp. Immunol 31 ; 72-8(1 1978. 21. Nielsen P. HymtoCt Petersen et al. Circulating Immune Complaxes in Ulceratice Colitis. Correltion with serum protein Concentration and Complement con.cersion products. Clin Exp. Immunol 31 : 81-91, 1978.

22. Press and J. Gagnon, Biochem J. 1988 351-357, 1981.

23. Selby S.W. Jewell PD.T. Lymphocyte Subsets in Inflammatory Bowel Disease .Peripheral Blood. Gut 24 99-105, 1983.

24. Tanner R.N., Arthur P,J.M.r wright n Macrophage Activation, Chronic Inflammation and Gastroentestinal Disease, Gut 25 : 760-783, 1984.