Ankara Üniversitesi Tıp Fakültesi Mecmuası 0365-8104 1307-5608 Ankara University Pathology Patoloji Timomalar Thymomas Bulay Orhan ANKARA UNIVERSITY, ANKARA FACULTY OF MEDICINE 09 30 1975 28 3-4 831 847 07 01 1975 09 30 1975 Copyright © 1947, Ankara Üniversitesi Tıp Fakültesi Mecmuası 1947 Ankara Üniversitesi Tıp Fakültesi Mecmuası

Bölümümüzdeki cerrahi örnekleri 1950 - 1.974 yılları arasında retrospektif olarak incelediğimizde, 8'i cerrahi örnek ve geri kalanı biyopsi olmak üzere on bir timoma bulduk. Cinsiyet dağılımının oranı erkek lehine 3'e 1'dir. En sık görüldüğü tümör dördüncü on yıldır.Timomaların histolojik tanısı şu şekilde dağılmıştır: 4 Lenfositik tip (%36), 5 Epitel tipi (%45), I Mixt tip (Lenfoid-Epitel) ve I Granülomatöz tip Timomalar hakkındaki isimler ve açıklamalar arasındaki fark, tümörün mixt hücresel bileşiminden ve timusun kendisinin farklı unsurlarından kaynaklanmaktadır. Serimizde kullanılan sınıflandırma Lattes'e dayanmaktadır {24).Malign timomalar için mevcut görüş doğası gereği invazivdir ve kapsüllenmiş olabilirler veya olmayabilirler.Bir diğer zorluk da, timomanın granülomatöz tip veya Hodgkin Hastalığı olup olmadığını teşhis etmektir. Granülomatöz tip timomanın tanımı, timusun kendisindeki yerleşim gibi bazı sınırlamalara ihtiyaç duyar; v: periferik lenf düğümlerine invazyon kanıtı olmadan, ve Sternberg-Dorothy-Reed hücrelerindeki PAS pozitif materyalin epitel kökenli olduğu düşünülmelidir.

St.udying retrospectively the surgical specimens in our department from 1950 - 1.974 we ha,ve found eleven thymomas, 8 of which are surgical specimens and the rest are biopsies. The ratio of the distribution 'of the sex is 3 to I in favour of male- The tumour where it.'s most frequently seen, is the fourth decade. The histologic diagnosis of thymomas is distributed as fol„ Iows : 4 Lymphocytic type (36%), 5 Epitheliai typp (45%), I Mixt type (Lymphoid-Epithelial) and I Granulomatous type The difference betveen the names and description about the thymoma.s come from the mixt cellular composition of the tumor and from the different elements of the thymus itseif. The classification used in our series is based on Lattes {24) .Current view for malignant thymomas are invasive in nature and they may be encapsulated or they may not.Another difficufty is to diagnose a thymorna i,vhether it's granuk)rnatous type or Hodgkin's Disease. The description of granulomatous type thymoma needs some limitations such as the location in thymus itself; v:ithout any evidence of invasion of peripheral lymph nodes, and PAS positive material in Sternberg-Dorothy-Reed cells must have been thought epithelial in origin.

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