Ankara Üniversitesi Tıp Fakültesi Mecmuası 0365-8104 1307-5608 Ankara University Anaesthesiology Anesteziyoloji New Views On The Biotransformation Of Anesthetic Drugs And Their Application Anestezik İlaçların Biyotransformasyonu ve Uygulama Yönünden Yeni Görüşler Paykoç Refik ANKARA ÜNİVERSİTESİ, ANKARA TIP FAKÜLTESİ 06 30 1975 28 1-2 449 458 01 01 1975 03 29 1975 Copyright © 1947, Ankara Üniversitesi Tıp Fakültesi Mecmuası 1947 Ankara Üniversitesi Tıp Fakültesi Mecmuası

Unusual reaction to anesthetic agents is not a rare entity in Practice of Anesthesia some of the clinically important reactions include Halothane Hepatotoxicity, Methoxyflurane Nefrotoxicity and the malignant Hyperthermia.In this article new concepts of anesthetic biotransformation and its application to clinical practice is explained. For the time being, the effects of metabolism on clinical toxicity of genera] anesthetic agents seems like a valid hypothesis.

Anestezi uygulamasında anestezik aianlara karsl anormal reaksiyonlarln görülmesi nadir dežildir. Bu reaksiyonlar araslnda klinik önemi olanlar halotan hepatotoksisitesi, methoxyflurane nefrotoksisitesi ve malign hipertermidir.Bu makalede anestezik maddelerin biyotransformasyonunda yeni görüsler ve bunun klinik uygulamaya olan etkisi izah edilmege çall}llmaktadlr. Bugün için anestezik maddelere karsl görülen anormal reaksiyonlarln metabolik etki ile izahl geçerli bir hipotez gibi görülmektedir.

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