Ankara Üniversitesi Tıp Fakültesi Mecmuası 0365-8104 1307-5608 Ankara University Endocrinology Endokrinoloji A Study on the Values of Static and Dynamic Biological Tests Used in the Diagnosis of Hypersomatotropinism and Its Complications Hipersomatotropinizm Ve Komplikasyonlarının Teşhisinde Yararlanılan Statik Ve Dinamik Biyolojik Testlerin Değerleri Üzerinde İnceleme Koloğlu Selahattin A. Ü. Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları Kürsüsü 12 30 1974 27 3-4 739 756 09 01 1974 12 30 1974 Copyright © 1947, Ankara Üniversitesi Tıp Fakültesi Mecmuası 1947 Ankara Üniversitesi Tıp Fakültesi Mecmuası

The role of routine, classic, and modern diagnostic tests in the diagnosis of active hypersomatotropinism was investigated by examining 80 cases of acromegaly.Phosphoremia and diurnal variations in phosphorus levels did not provide significant information for diagnosis or for the determination of disease activity.The examination of basal somatotropin (STH) levels was found to be useful in determining activity, except in 7.5% of the cases. It became apparent that at least two basal STH determinations in each case are essential for diagnosis.In cases of 'forme fruste' or inactive acromegaly, and for monitoring the effectiveness of treatment in previously treated patients, early diagnosis is only possible through the dynamic study of STH secretion. In this regard, the determination of autonomous STH secretion via insulin stimulation and glucose suppression tests is the most significant evidence for disease activity. In contrast, demonstrating the stimulability and suppressibility of this secretion serves as the most crucial evidence for treatment effectiveness.

80 akromegali vakası incelenerek, rutin, klasik ve modern teşhis testlerinin aktif hipersomatotropinizm teşhisindeki yeri araştırılmıştır.Fosforemi ve fosfor seviyelerindeki diurnal değişiklikler teşhis bakımından veya aktivitenin meydana çıkarılışında; önemli bilgi sağlayamamıştır.Bazal somatotropin (STH) seviyelerinin incelenmesi, vakaların % 7,5'u hariç, aktivitenin meydana çıkarılışında faydalı olmuştur. Her vakada en az iki bazal STH tayininin, teşhis bakımından, elzem olduğu meydana çıkmıştır.Frust veya inaktivite safhasındaki bir akromegalide erken teşhis veya tedavi görmüş vakalarda tedavinin etkenliğinin takibi, ancak STH salgısının dinamik incelenmesile mümkündür. Bu bakımdan insülin stimülasyonu ve glikoz supresyonu ile STH salgısındaki otonominin tesbiti aktivite lehinde, aynı salgının stimulabilite ve supresibilitesinin meydana çıkarılışı ise tedavinin etkenliği lehinde en önemli delillerdir.

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