Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Ankara University

Internal Diseases

İç Hastalıkları

THAM (Tris Hydroxymethyl Aminomethane)'nın Antiaritmik Etkisi

Antiarrhythmic Effect of THAM (Tris Hydroxymethyl Aminomethane)

Sonel

Ahmet

ANKARA ÜNİVERSİTESİ, ANKARA TIP FAKÜLTESİ

06 30 1973

26 3 537 542 05 01 1973 06 30 1973

1947

Ankara Üniversitesi Tıp Fakültesi Mecmuası

Bu çalışma, asidozu düzeltici bir madde olarak bilinen ve kulla- nılan THAM'ın antiaritmik tesirini incelemek gayesi ile yapılmıştır. THAM'ın ventriküler ektopik aritmilerden V.P.S. lerde yüksek nisbette tesirli olduğu sonucuna varılmıştır,

The purpose of this study is to investigate the antiarrhytmiceffect of THAM Which has been used in practice as a buffer solution in the correction of asidosis.İt has been concluded that THAM is highly effective in abolishing ectopic rythms particularly VPS.

antiaritmik THAM ektopik

antiarrhytmic THAM ectopic

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2 — CLİNE,R. E, WALLALE, A.G., SEALY, W.C, YOUNG, W.G.: Antiarrhytmic properties of tris (Hydroxymethyl Aminomethane), Am, J, Curdial, 21 : 38, 1968,

3 — CONN, H, L, LUCHİ, RJ,: Some cellular and metfabolic considerations relating to the action or guinidine as a profotypo antiurrhytmic agent, Am, J, Med., 37 : 685, 1964.

4 — MÜHLER, HR.: The use of amino buffers in studies witli enzymes, Ann New - York Acad, Sc,, 92: 426, 1961

5 — LUCHİ, RJ, CONN, H. L, HELWİG, J;: Cardiovascular effects of a guiniğine related compound, 4 hydroxymethyl 6 methoxy guinidine, An, J, Cardiol 10 : 252, 1962.

6 — WEGRIA,R.,, NICKERSON, N.D.: The effect of papavcrinc and guinidine on the fibrillation thresholds of the mammalion venricles, J, Pharmucol, Exper, Therap. 75 : 50, 1942.