<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article  article-type="research-article"        dtd-version="1.4">
            <front>

                <journal-meta>
                                    <journal-id></journal-id>
            <journal-title-group>
                                                                                    <journal-title>Ankara Üniversitesi Tıp Fakültesi Mecmuası</journal-title>
            </journal-title-group>
                            <issn pub-type="ppub">0365-8104</issn>
                                        <issn pub-type="epub">1307-5608</issn>
                                                                                            <publisher>
                    <publisher-name>Ankara University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id/>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Medical Biochemistry - Amino Acids and Metabolites</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Tıbbi Biyokimya - Amino Asitler ve Metabolitler</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <trans-title-group xml:lang="en">
                                    <trans-title>Acute Phenylbutazone (Butazolidin) Poisoning</trans-title>
                                </trans-title-group>
                                                                                                                                                                                                <article-title>Akut Fenilbutazon (Butazolidin) Zehirlenmesi</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                <name>
                                    <surname>Sökmen</surname>
                                    <given-names>Cavit</given-names>
                                </name>
                                                                    <aff>ANKARA UNIVERSITY, ANKARA FACULTY OF MEDICINE</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="19630630">
                    <day>06</day>
                    <month>30</month>
                    <year>1963</year>
                </pub-date>
                                        <volume>16</volume>
                                        <issue>2</issue>
                                        <fpage>163</fpage>
                                        <lpage>165</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="19630401">
                        <day>04</day>
                        <month>01</month>
                        <year>1963</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="19630630">
                        <day>06</day>
                        <month>30</month>
                        <year>1963</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 1947, Ankara Üniversitesi Tıp Fakültesi Mecmuası</copyright-statement>
                    <copyright-year>1947</copyright-year>
                    <copyright-holder>Ankara Üniversitesi Tıp Fakültesi Mecmuası</copyright-holder>
                </permissions>
            
                                                                                                <trans-abstract xml:lang="en">
                            <p>This study presents a case of acute poisoning in an 18-year-old female who ingested 12.4 grams of phenylbutazone (Butazolidin) in a suicide attempt. The patient was admitted to the clinic in a comatose state 11 hours after ingestion, exhibiting convulsions and loss of consciousness. Consciousness returned within a few hours, followed by the onset of jaundice and renal dysfunction symptoms, which resolved within 15 days. Mild leukopenia was observed, but agranulocytosis did not develop. Laboratory findings indicated temporary liver and kidney dysfunction, which improved over time. This case highlights the toxic effects of high-dose phenylbutazone on the central nervous system, liver, and kidneys.</p></trans-abstract>
                                                                                                                                    <abstract><p>Bu çalışmada, intihar amacıyla 12.4 gram fenilbutazon (Butazolidin) alan 18 yaşındaki bir genç kızın akut zehirlenme vakası sunulmuştur. Hasta, ilacı aldıktan 11 saat sonra komaya girerek kliniğe getirilmiştir. Başlangıçta konvülsiyonlar ve şuur kaybı gözlenmiş, birkaç saat içinde bilinç geri dönmüştür. Takip eden günlerde sarılık ve böbrek disfonksiyonu belirtileri ortaya çıkmış, bu belirtiler 15 gün içinde kaybolmuştur. Hastada hafif lökopeni gelişmiş ancak agranülositoz görülmemiştir. Laboratuvar bulgularında karaciğer ve böbrek fonksiyon bozuklukları tespit edilmiş, ancak bu bozukluklar zamanla düzelmiştir. Vaka, fenilbutazonun yüksek dozda alımının merkezi sinir sistemi, karaciğer ve böbrekler üzerindeki toksik etkilerini göstermesi açısından önemlidir.</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>akut</kwd>
                                                    <kwd>  zehirlenme</kwd>
                                                    <kwd>  disease</kwd>
                                            </kwd-group>
                            
                                                                                                                                                    </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">1 — BRODIE, B. B.; LOWMAN, E. W.; BURNS, J. J. ve LEE, R. P.: Phenylbutazone&#039;un (Butazolidin) Antiromatizmal ve Fizyolojik Etkileri ile Kortizonla Karşılaştırılması. Am. J. Med. 16: 181, 1954.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">2 — DRIEL, A. V.: Tıpta Farmakoloji, Mc Graw Hill Book Co. 1954, New York.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">3 — BRUCK, E.; FERNLEY, M. E.; MEANOCK, I. ve PATLEY, H.: Phenylbutazone Tedavisi, The Lancet. 1:225, 1954.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">4 — MAURER, E. F.: Phenylbutazone&#039;un (Butazolidin) Toksik Etkileri. New Engl. J. Med. 253: 405, 1955.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
