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Akut iskemik inmede intravenöz trombolitik tedavi

Year 2012, Volume: 65 Issue: 2, 103 - 106, 01.02.2012
https://doi.org/10.1501/Tipfak_0000000817

Abstract

References

  • Adams RD, Victor M, Ropper AH. Principles of Neurology 7th ed. Mc Graw-Hill; 2009.
  • Silverman IE, Rymer MM. An Atlas of Investigation and Treatment Ischemic Stroke. 1st ed. Clnical Publishing; 2009.
  • Caplan LR. Caplan’s Stroke: A Clinical Approach. 4th ed. Elsevier; 2009.
  • The National Institute of Neurological Disorders rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995; 333: 1581-1587.
  • Wardlaw J, Berge E, del Zoppo G, and Yamaguchi T. Thrombolysis for Acute Ischemic Stroke. Stroke. 2004; 35: 2914- 2915.
  • Wahlgren N, Ahmed N, Davalos A; SITS- MOST Investigators. Thrombolysis with alteplase for acute ischemic stroke in the Safe Implementation of Thrombolysis in Stroke Monitoring Study (SITSMOST): an observational study. Lancet. 2007; 369(9558): 275-282.
  • Hacke W, Kaste M, Bluhmki E, et al. ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008; 359:1317–1329.
  • Food and Drug Administration. Product approval action:alteplase (Activase). June 18, 1996. licensing
  • European Medicines Agency. Committee for Proprietary Medicinal Products (CPMP). Summary information on a referral opinion following an arbitration pursuant to article 29 of directive 2001//83/EC, for Actilyse.
  • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581-7.
  • Dávalos A, Toni D, Iweins F, Lesaffre E, Bastianello S, Castillo J. Neurological deterioration in acute ischemic stroke: potential factors in the European cooperative acute stroke study (ECASS) I. Stroke. 1999 Dec;30(12):2631-6. associated
  • Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA 1999;282:2019- 26. randomized
  • Albers GW, Bates VE, Clark WM, Bell R, Verro P, Hamilton SA. Intravenous tissue-type plasminogen activator for treatment of acute stroke: The Standard Treatment with Alteplase to Reverse Stroke 2000;283:1145-50. JAMA
  • Wardlaw JM, Warlow CP. Thrombolysis in acute ischemic stroke: Does it work? Stroke 1992;23:1826-39.

Akut İskemik İnmede İntravenöz Trombolitik Tedavi

Year 2012, Volume: 65 Issue: 2, 103 - 106, 01.02.2012
https://doi.org/10.1501/Tipfak_0000000817

Abstract

Amaç: Trombolitik tedavinin amacı akut iskemik inmede rekanalizasyonu sağlayarak penumbrayı kurtarmaktır. Bu çalıșmanın amacı bizim intravenöz trombolitik tedavi uyguladığımız hastalarımızda tedavinin etkinliğini ve komplikasyon oranlarını değerlendirmektir. Hastalar ve Yöntem: Semptomların bașlamasından itibaren ilk 4.5 saatte bașvuran ve intravenöz trombolitik tedavi alan 32 hastayı retrospektif olarak inceledik. Hastaların tedavi öncesi ve tedavi sonrası Ulusal Sağlık Enstitüsü Strok Skalası (NIHSS) ve modifiye Rankin Skalası skorları (mRS) değerlendirildi. Bulgular: Tedavi öncesi, tedavi sonrası 24. saatte, 7. günde ve üçüncü aydaki NIHSS ortalamaları sırası ile 15±6, 10±6, 8±6 ve 8±7 idi. Tedavi sonrası 24. saatteki ve 3. aydaki mRS ortalaması ise 4±1 ve 3±2 olarak izlenmiștir. NIHSS karșılaștırıldığında tedavi alan grupta anlamlı düzelme tespit edildi (p=0.001). Tedavi sonrası 5 (%15.6) hastada intrakraniyal kanama tespit edildi. Yalnızca bir (%3.1) hastada ölümcül kanama oldu. Yorum: İlk 4.5 saatte akut iskemik inme ile bașvuran uygun hastalarda intravenöz trombolitik tedavi uygulaması kolay ve etkili bir yöntemdir. İnme bir halk sağlığı sorunudur ve bu tedavi ile bağımsız olarak yașamını sürdüren hasta sayısını arttırabiliriz.

References

  • Adams RD, Victor M, Ropper AH. Principles of Neurology 7th ed. Mc Graw-Hill; 2009.
  • Silverman IE, Rymer MM. An Atlas of Investigation and Treatment Ischemic Stroke. 1st ed. Clnical Publishing; 2009.
  • Caplan LR. Caplan’s Stroke: A Clinical Approach. 4th ed. Elsevier; 2009.
  • The National Institute of Neurological Disorders rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995; 333: 1581-1587.
  • Wardlaw J, Berge E, del Zoppo G, and Yamaguchi T. Thrombolysis for Acute Ischemic Stroke. Stroke. 2004; 35: 2914- 2915.
  • Wahlgren N, Ahmed N, Davalos A; SITS- MOST Investigators. Thrombolysis with alteplase for acute ischemic stroke in the Safe Implementation of Thrombolysis in Stroke Monitoring Study (SITSMOST): an observational study. Lancet. 2007; 369(9558): 275-282.
  • Hacke W, Kaste M, Bluhmki E, et al. ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008; 359:1317–1329.
  • Food and Drug Administration. Product approval action:alteplase (Activase). June 18, 1996. licensing
  • European Medicines Agency. Committee for Proprietary Medicinal Products (CPMP). Summary information on a referral opinion following an arbitration pursuant to article 29 of directive 2001//83/EC, for Actilyse.
  • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995;333:1581-7.
  • Dávalos A, Toni D, Iweins F, Lesaffre E, Bastianello S, Castillo J. Neurological deterioration in acute ischemic stroke: potential factors in the European cooperative acute stroke study (ECASS) I. Stroke. 1999 Dec;30(12):2631-6. associated
  • Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S. Recombinant tissue-type plasminogen activator (Alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. JAMA 1999;282:2019- 26. randomized
  • Albers GW, Bates VE, Clark WM, Bell R, Verro P, Hamilton SA. Intravenous tissue-type plasminogen activator for treatment of acute stroke: The Standard Treatment with Alteplase to Reverse Stroke 2000;283:1145-50. JAMA
  • Wardlaw JM, Warlow CP. Thrombolysis in acute ischemic stroke: Does it work? Stroke 1992;23:1826-39.
There are 14 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Mine Hayriye Sorgun This is me

Canan Togay Işıkay This is me

Publication Date February 1, 2012
Published in Issue Year 2012 Volume: 65 Issue: 2

Cite

APA Sorgun, M. H., & Togay Işıkay, C. (2012). Akut İskemik İnmede İntravenöz Trombolitik Tedavi. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 65(2), 103-106. https://doi.org/10.1501/Tipfak_0000000817
AMA Sorgun MH, Togay Işıkay C. Akut İskemik İnmede İntravenöz Trombolitik Tedavi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. February 2012;65(2):103-106. doi:10.1501/Tipfak_0000000817
Chicago Sorgun, Mine Hayriye, and Canan Togay Işıkay. “Akut İskemik İnmede İntravenöz Trombolitik Tedavi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 65, no. 2 (February 2012): 103-6. https://doi.org/10.1501/Tipfak_0000000817.
EndNote Sorgun MH, Togay Işıkay C (February 1, 2012) Akut İskemik İnmede İntravenöz Trombolitik Tedavi. Ankara Üniversitesi Tıp Fakültesi Mecmuası 65 2 103–106.
IEEE M. H. Sorgun and C. Togay Işıkay, “Akut İskemik İnmede İntravenöz Trombolitik Tedavi”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 65, no. 2, pp. 103–106, 2012, doi: 10.1501/Tipfak_0000000817.
ISNAD Sorgun, Mine Hayriye - Togay Işıkay, Canan. “Akut İskemik İnmede İntravenöz Trombolitik Tedavi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 65/2 (February 2012), 103-106. https://doi.org/10.1501/Tipfak_0000000817.
JAMA Sorgun MH, Togay Işıkay C. Akut İskemik İnmede İntravenöz Trombolitik Tedavi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2012;65:103–106.
MLA Sorgun, Mine Hayriye and Canan Togay Işıkay. “Akut İskemik İnmede İntravenöz Trombolitik Tedavi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 65, no. 2, 2012, pp. 103-6, doi:10.1501/Tipfak_0000000817.
Vancouver Sorgun MH, Togay Işıkay C. Akut İskemik İnmede İntravenöz Trombolitik Tedavi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2012;65(2):103-6.