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The Effects Of Antiepileptic Drugs On Serum And Hair Trace Element Levels

Year 2008, Volume: 61 Issue: 2, 73 - 76, 01.02.2008

Deniz Tekin Haydar Ali Taşdemir Recep Saraymen

https://doi.org/10.1501/Tipfak_0000000655

Abstract

Keywords

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References

  • Wallwork JC. Zinc and central ner- vous system. Prog Food Nutri Sci 1987;11:203-247.
  • Ebadi M, Wilt S, Ramaley R, et al. The role of zinc and zinc-binding proteins in regulation of glutamic acid decar- boxylase in brain. In: Evangenopou- los AE, ed. Chemical and biological aspects of vitamin B6 catalysis: Part A New York: Alan R Liss, 1984: 255-75.
  • Smith WG, Bone I. Copper, zinc and magnesium plasma levels in epilepsy. J Neurol Neurosurg Psychiatry 1982; 45:1072.
  • Kandel ER. Transmitter release. In: Principles of neuronal science. Kan- del ER, Schwartz JH, Vessel TM (edi- tors) New York: Elsevier, 194-212.
  • Pippenger CE., Meng X, Van Leste F, et al. Valproate therapy depresses GSH-Px abd SOD enzyme activity. A possible mechanism for VPA induced idiosyncratic drug toxicity. Clinical Chemistry 1989; 35:1173-1177.
  • Schott GD, Delves HT. Plasma zinc le- vels with anticonvulsant therapy. Br J Clin Pharmacol 1978; 5:279-280.
  • Barbeau A, Donaldson J. Zinc, Ta- urine and epilepsy. Arch of Neurol 1974;30: 52-58.
  • Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992; 33: 555-557.
  • Lerman- Sagie T, Statter M, Szabo G, et al. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neurophar- macol 1987; 10:80-86.
  • Ghose K, Taylor A. Hypercupremia induced by antiepileptic drugs. Hum Toxicol 1983; 2:519-529.
  • Hurd RW, Van Rinsvelt HA, Wilder BJ, et al. Selenium, zinc and copper changes in valproic acid: possible correlation to drug side effects. Ne- urology 1984; 34:1393-1395.
  • Hamed SA, Abdellah MM, El-Melegy N. Blood levels of trace elements, electrolytes, and oxidative stres/anti- oxidant systems in epileptic patients. J Pharmacol Sci 2004; 96:465-473.
  • Kuzuya T, Hasegawa T, Shimizu K, et al. Effect of and antiepileptic drugs on serum zinc, copper concentrati- ons in epileptic patients. Int J Clin Pharmacol Ther Toxicol 1993; 31:61- 65.
  • Verrotti A, Basciani F, Trotta D, et al. Serum copper, zinc, selenium, glu- tathione peroxidase and superoxide dismutase levels in epileptic child- ren before and after 1 year of sodium valproate and carbamazepine the- rapy. Epilepsy Res 2002; 48: 71-75.
  • Armutcu F, Ozerol E, Gurel A, et al. Effect of long-term therapy with so- dium valproate on nail and serum trace element status in epileptic children. Biol Trace Elem Res. 2004; 102:1-10.
  • İlhan A, Uz E, Kali S, et al. Serum and hair trace element levels in patients with epilepsy and healthy subjects: does the antiepileptic therapy affect the element concentrations of hair? Eur J Neurology 1999; 6(6): 705- 709.
  • Altunbasak S, Biatmakoui F, Baytok V, et al. Serum and hair zinc levels in epileptic children taking valpro- ic acid. Biol Trace Elem Res 1997; 58:117-125.
  • Steidl L, Tolde I, Svomova V. Metabo- lism of magnesium and zinc in pati- ents treated with antiepileptic drugs and with magnesium lactate. Magne- sium 1987; 6: 284-295.
  • Shaw JCL. Trace elements in the fetus and young infant. Am J Dis Child 1979; 133: 1260-1264.

Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri

Year 2008, Volume: 61 Issue: 2, 73 - 76, 01.02.2008

Deniz Tekin Haydar Ali Taşdemir Recep Saraymen

https://doi.org/10.1501/Tipfak_0000000655

Abstract

Amaç: Antiepileptik ilaçların serum ve saç eser element düzeylerini etkileyip etkilemediğini göstermek için epilepsi tanısı alan 40 çocuğu değerlendirdik. Gereç ve Yöntem: Serum Zn, Cu, Mg ile saç Zn düzeyleri fenobarbital veya valproik asit tedavisi başlanmadan önce ve 3 ay sonra değerlendirildi. Bulgular: Her iki tedavi ile de serum Zn düzeyleri düştü. Fenobarbital veya Valproik asit tedavisi alan epileptik hastalar karşılaştırıldığında, fenobarbital tedavisi alanlarda serum Zn düzeylerindeki düşme daha belirgindi. Sonuç: Hastalarımızın hiçbirinde Zn eksikliğine bağlı bulgular görmesek de, Fenobarbital veya Valproik asit tedavisi alan çocuklarda bu açıdan dikkatli olunmalıdır.

Keywords

Antiepileptik ilaçlar epilepsi eser element düzeyleri

References

  • Wallwork JC. Zinc and central ner- vous system. Prog Food Nutri Sci 1987;11:203-247.
  • Ebadi M, Wilt S, Ramaley R, et al. The role of zinc and zinc-binding proteins in regulation of glutamic acid decar- boxylase in brain. In: Evangenopou- los AE, ed. Chemical and biological aspects of vitamin B6 catalysis: Part A New York: Alan R Liss, 1984: 255-75.
  • Smith WG, Bone I. Copper, zinc and magnesium plasma levels in epilepsy. J Neurol Neurosurg Psychiatry 1982; 45:1072.
  • Kandel ER. Transmitter release. In: Principles of neuronal science. Kan- del ER, Schwartz JH, Vessel TM (edi- tors) New York: Elsevier, 194-212.
  • Pippenger CE., Meng X, Van Leste F, et al. Valproate therapy depresses GSH-Px abd SOD enzyme activity. A possible mechanism for VPA induced idiosyncratic drug toxicity. Clinical Chemistry 1989; 35:1173-1177.
  • Schott GD, Delves HT. Plasma zinc le- vels with anticonvulsant therapy. Br J Clin Pharmacol 1978; 5:279-280.
  • Barbeau A, Donaldson J. Zinc, Ta- urine and epilepsy. Arch of Neurol 1974;30: 52-58.
  • Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia 1992; 33: 555-557.
  • Lerman- Sagie T, Statter M, Szabo G, et al. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neurophar- macol 1987; 10:80-86.
  • Ghose K, Taylor A. Hypercupremia induced by antiepileptic drugs. Hum Toxicol 1983; 2:519-529.
  • Hurd RW, Van Rinsvelt HA, Wilder BJ, et al. Selenium, zinc and copper changes in valproic acid: possible correlation to drug side effects. Ne- urology 1984; 34:1393-1395.
  • Hamed SA, Abdellah MM, El-Melegy N. Blood levels of trace elements, electrolytes, and oxidative stres/anti- oxidant systems in epileptic patients. J Pharmacol Sci 2004; 96:465-473.
  • Kuzuya T, Hasegawa T, Shimizu K, et al. Effect of and antiepileptic drugs on serum zinc, copper concentrati- ons in epileptic patients. Int J Clin Pharmacol Ther Toxicol 1993; 31:61- 65.
  • Verrotti A, Basciani F, Trotta D, et al. Serum copper, zinc, selenium, glu- tathione peroxidase and superoxide dismutase levels in epileptic child- ren before and after 1 year of sodium valproate and carbamazepine the- rapy. Epilepsy Res 2002; 48: 71-75.
  • Armutcu F, Ozerol E, Gurel A, et al. Effect of long-term therapy with so- dium valproate on nail and serum trace element status in epileptic children. Biol Trace Elem Res. 2004; 102:1-10.
  • İlhan A, Uz E, Kali S, et al. Serum and hair trace element levels in patients with epilepsy and healthy subjects: does the antiepileptic therapy affect the element concentrations of hair? Eur J Neurology 1999; 6(6): 705- 709.
  • Altunbasak S, Biatmakoui F, Baytok V, et al. Serum and hair zinc levels in epileptic children taking valpro- ic acid. Biol Trace Elem Res 1997; 58:117-125.
  • Steidl L, Tolde I, Svomova V. Metabo- lism of magnesium and zinc in pati- ents treated with antiepileptic drugs and with magnesium lactate. Magne- sium 1987; 6: 284-295.
  • Shaw JCL. Trace elements in the fetus and young infant. Am J Dis Child 1979; 133: 1260-1264.
There are 19 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Deniz Tekin This is me

Haydar Ali Taşdemir This is me

Recep Saraymen This is me

Publication Date February 1, 2008
Published in Issue Year 2008 Volume: 61 Issue: 2

Cite

APA Tekin, D., Taşdemir, H. A., & Saraymen, R. (2008). Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 61(2), 73-76. https://doi.org/10.1501/Tipfak_0000000655
AMA Tekin D, Taşdemir HA, Saraymen R. Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri. Ankara Üniversitesi Tıp Fakültesi Mecmuası. February 2008;61(2):73-76. doi:10.1501/Tipfak_0000000655
Chicago Tekin, Deniz, Haydar Ali Taşdemir, and Recep Saraymen. “Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 61, no. 2 (February 2008): 73-76. https://doi.org/10.1501/Tipfak_0000000655.
EndNote Tekin D, Taşdemir HA, Saraymen R (February 1, 2008) Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri. Ankara Üniversitesi Tıp Fakültesi Mecmuası 61 2 73–76.
IEEE D. Tekin, H. A. Taşdemir, and R. Saraymen, “Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 61, no. 2, pp. 73–76, 2008, doi: 10.1501/Tipfak_0000000655.
ISNAD Tekin, Deniz et al. “Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 61/2 (February 2008), 73-76. https://doi.org/10.1501/Tipfak_0000000655.
JAMA Tekin D, Taşdemir HA, Saraymen R. Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2008;61:73–76.
MLA Tekin, Deniz et al. “Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 61, no. 2, 2008, pp. 73-76, doi:10.1501/Tipfak_0000000655.
Vancouver Tekin D, Taşdemir HA, Saraymen R. Antiepileptik İlaçların Serum Ve Saçta Eser Element Düzeylerine Etkileri. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2008;61(2):73-6.