ankara univ vet fak derg

Ankara Üniversitesi Veteriner Fakültesi Dergisi

1300-0861 1308-2817

Ankara University

10.1501/Vetfak_0000002481

Veterinary Surgery

Veteriner Cerrahi

Investigation of the long term effects of chronic white noise stress on learning in radial arm maze and behaviors in forced swim test

Kronik beyaz gürültü stresinin radyal labirentte öğrenme ve zorunlu yüzme testinde davranışlarüzerine olan uzun dönem etkilerinin araştırılması

Uygur

Evren Eraslan

Ekiz

Elif Ergül

Akyazı

İbrahim

Gültekin

İnal Güldal

Arslan

Murat

12 01 2011

58 4 233 238 12 01 2011

1954

Ankara Üniversitesi Veteriner Fakültesi Dergisi

The long-term effects of 100 dB chronic white noise stress (WNS), exposed during prenatal and adolescent periods, on some cognitive functions and behaviors in rats were investigated. For this purpose, 40 female Sprague Dawley rats and their 60 male offspring were used. Pregnant rats were divided into Prenatal Stress (PS) and Prenatal Control (PC) groups. Noise stress was applied to PS group between the 14th and 21st days of their pregnancy, while PC rats were left undisturbed. After weaning, 60 male pups of PS dams were assigned to prenatal + chronic postnatal stress (PSCS), prenatal stress + non stress (PSN) and Control (CON) groups. During the postnatal 30th and 51st days, WNS was applied to PSCS rats, while PSN and CON groups were left undisturbed. The effects of stress on adult male offspring were investigated using 8-arm radial maze and forced swimming tests. There were no significant differences among groups for cognition and behavior tests. These results indicate that chronic 100 dB WNS does not have log-term effects on cognitive functions and depression related behaviors of adult male offspring

Çalışmada sıçanlarda prenatal ve adolesan dönemlerde uygulanan kronik, 100 dB şiddetindeki beyaz gürültü stresinin bazı davranışlar ve kognitif fonksiyonlar üzerine olan uzun dönem etkileri araştırılmıştır. Bu amaçla 40 adet dişi Sprague Dawley sıçan ve bunlardan elde edilen 60 erkek sıçan kullanıldı. Gebe dişiler Prenatal Stres (PS) ve Prenatal Kontrol (PK) grubu olmak üzere iki gruba ayrıldılar. Gebeliğin 14. ve 21. günleri arasında PS grubuna ses stresi uygulanırken, kontrol grubuna herhangi bir uygulama yapılmadı. Yavrular sütten kesildikten sonra PS grubu dişilerden elde edilen 60 adet erkek yavru prenatal stres + kronik postnatal stres (PSKS), prenatal stres + stres uygulanmayan (PSSU) ve Kontrol (KON) gruplarına ayrıldılar. PSKS grubu ratlara postnatal dönemin 30. ve 51. günleri arasında stres uygulaması yapılırken, PS ve KON grubundaki ratlara herhangi bir uygulama yapılmadı. Stresin etkileri erişkin erkek sıçanlarda sekiz kollu radyal labirent testi ve zorlamalı yüzme testi kullanılarak ölçüldü. Kognitif ve davranışsal testler açısından gruplar arasında önemli bir farklılık bulunmadı. Elde edilen sonuçlar kronik, 100 dB beyaz ses stresinin erişkin erkek sıçanlarda kognitif fonksiyonlar ve depresyonla ilişkili davranışlar üzerinde uzun dönem etkisinin olmadığını göstermektedir

cognition forced swim rats stress white noise

beyaz gürültü kognisyon rat stres zorunlu yüzme

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