Epigenetik ve Böbrek Hastalıkları

Year 2020, Volume: 3 Issue: 3, 161 - 166, 30.09.2020

Ümüş Özbey Yücel , Aslı Akyol Mutlu

Abstract

Epigenetik DNA diziliminde bir değişiklik olmadan gen ifadelenmesinde meydana gelen kalıtsal değişiklikler olarak tanımlanmaktadır. Bu konuda yapılan çalışmalar, çoğunlukla hastalıkların fetal orijinleri ile ilgilenmekte ve çevresel faktörlerin aracı olduğu rahim içi maruziyetlerin hastalıklar üzerindeki etkilerini araştırmaktadır. Son yıllarda böbrek hastalıkları ile ilişkili olarak yapılan epigenetik çalışma sayısı giderek artmakta ve beslenme şeklinin böbrek hastalıkları ile ilişkili epigenetik varyasyonları etkilediği bildirilmektedir. Bu çalışmalar maternal olarak yetersiz-aşırı beslenme veya gestasyonel diyabetin yavrunun böbrek fonksiyonları üzerine etkisine yoğunlaşmaktadır. Buna göre annenin beslenme şekli doğrudan veya dolaylı olarak yavrunun nefron sayısı, glomerulofiltrasyın hızı (GFR) ve renin-anjiotensin sistemini (RAS) değiştirmekte ve hem doğum sonrası erken dönemde hem de yaşamın ilerleyen yıllarında etkisini göstermektedir. Bu derlemede, maternal beslenme şeklinin yavrunun böbrek fonksiyonları ile bağlantılı epigenetik parametreler üzerine ilişkisinin incelenmesi amaçlanmıştır.

Keywords

Böbrek hastalıkları, Epigenetik, Maternal beslenme

Supporting Institution

yoktur.

Project Number

yoktur.

Epigenetics and Kidney Diseases

Abstract

Epigenetics is defined as hereditary changes that occur in the expression of a gene without a change in the DNA sequence. Studies in this area are often concerned with fetal origins of diseases and investigate the effects of uteroplecental exposures, which are mediators of environmental factors, on disease. In recent years, the number of epigenetics studies related to kidney diseases has been increasing and it has been reported that the nutritional profile affects epigenetic variations related to kidney diseases. These studies focus on the effects of fetal kidney function on maternal insufficiency or over nutrition, obesity and gestational diabetes. Accordingly, the nutritional habits of the mother directly or indirectly changes the nephron number, glomerulofiltration rate (GFR) and renin-angiotensin system (RAS) of the offspring and affects both in the post-natal period and later in life. In this review, we aimed to investigate the effect of maternal nutrition on the epigenetic parameters associated with renal function and nephropatic complications of the offspring.

Keywords

Epigenetic, Kidney diseases, Maternal nutrition

Project Number

yoktur.

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