biodicon Biological Diversity and Conservation 1308-5301 1308-8084 Ersin YÜCEL 10.46309/biodicon.2026.1794117 Pharmacology and Pharmaceutical Sciences (Other) Eczacılık ve İlaç Bilimleri (Diğer) Synthesis of various DNA hybrid nanocomposites and investigation of peroxidase mimic activity Çeşitli DNA hibrit nanokompozitlerin sentezlenmesi ve enzimatik aktivitenin incelenmesi https://orcid.org/0000-0002-5703-2375 Çelik Yoldaş Çağla HARRAN UNIVERSITY, FACULTY OF PHARMACY https://orcid.org/0009-0000-3635-5573 Demir Ali ERCIYES UNIVERSITY, FACULTY OF PHARMACY https://orcid.org/0009-0007-3040-091X Nacar Asena Elif ERCIYES UNIVERSITY, FACULTY OF PHARMACY https://orcid.org/0000-0002-5991-3934 Öçsoy İsmail ERCIYES UNIVERSITY, FACULTY OF PHARMACY 02 16 2026 19 1 1 9 09 30 2025 11 15 2025 Copyright © 2008, Biological Diversity and Conservation 2008 Biological Diversity and Conservation

AbstractPurpose: The aim of this study is to synthesize hybrid nanocomposites from various DNA sequences and to investigate their peroxidase mimic activities.Method: The DNA sequences were used as the organic component and the copper (II) ions were used as the inorganic component for the synthesis. The effect of different synthesis conditions (pH and concentration) on morphology was investigated using a scanning electron microscope. Additionally, the peroxidase mimic activity of nanocomposites was examined.Findings: DNA sequences coded as C20, C20A and C20AA were used at various concentrations within three synthesis environments with different pH levels. This resulted in the formation of flower-like hybrid nanocomposite structures. These structures also exhibited effective peroxidase mimic activity.Conclusion: Various DNA hybrid nanocomposites can be synthesised successfully. These nanocomposites could be used in DNA-related drug delivery systems.

ÖzetAmaç: Bu çalışmanın amacı çeşitli DNA sekanslarından hibrit nanokompozitler sentezlenmesi ve peroksidaz benzeri aktivitelerinin araştırılmasıdır.Metod: Sentez için organik kısım olarak DNA sekansları, inorganik kısım olarak bakır (II) iyonları kullanılmıştır. Taramalı elektron mikroskobu ile farklı sentez şartlarının (pH, konsantrasyon) morfolojiye olan etkisi incelenmiştir. Ayrıca nanokompozitlerin peroksidaz benzeri aktivitesi araştırılmıştır.Bulgular: C20, C20A ve C20AA kodlu DNA sekansları farklı konsantrasyonlarda kullanılarak farklı pH değerine sahip üç farklı sentez ortamında istenilen çiçek benzeri hibrit nanokompozit yapılar oluşmuştur. Bu yapılar etkili peroksidaz enzim benzeri aktivite de sergilemişlerdir.Sonuç: Çeşitli DNA sekanslarından DNA hibrit nanokompozitler başarıyla sentezlenebilmektedir. Bu nanokompozitler DNA ilişkili ilaç taşıyıcı sistemlerde kullanılabilme potansiyeli taşımaktadır.

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