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Year 2015, Volume: 32 Issue: 4, 371 - 376, 01.10.2015

Abstract

References

  • 1. Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics 1974;54:271-6.
  • 2. Kato H, Ichinose E, Yoshioka F, Takechi T, Matsunaga S, Suziki K, et al. Fate of coronary aneurysms in Kawasaki disease: serial coronary angiography and long-term follow-up study. Am J Cardiol 1982;49:1758-66. [CrossRef]
  • 3. Huang WC, Huang LM, Chang IS, Chang LY, Chiang BL, Chen PJ, et al. Epidemiologic features of Kawasaki disease in Taiwan, 2003-2006. Pediatrics 2009;123:e401-5. [CrossRef]
  • 4. Nakamura Y, Yashiro M, Uehara R, Oki I, Kayaba K, Yanagawa H. Increasing incidence of Kawasaki disease in Japan: nationwide survey. Pediatr Int 2008;50:287-90. [CrossRef]
  • 5. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004;110:2747-71. [CrossRef]
  • 6. Perrin L, Letierce A, Guitton C, Tran TA, Lambert V, Kone-Paut I. Comparative study of complete versus incomplete Kawasaki disease in 59 pediatric patients. Joint Bone Spine 2009;76:481-5. [CrossRef]
  • 7. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55-9. [CrossRef]
  • 8. Gökhan S, Ozhasenekler A, Mansur Durgun H, Akil E, Ustündag M, Orak M. Neutrophil lymphocyte ratios in stroke subtypes and transient ischemic attack. Eur Rev Med Pharmacol Sci 2013;17:653-7.
  • 9. Yoon NB, Son C, Um SJ. Role of the neutrophil-lymphocyte count ratio in the differential diagnosis between pulmonary tuberculosis and bacterial community-acquired pneumonia. Ann Lab Med 2013;33:105-10. [CrossRef]
  • 10. Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J 2007;154:995-1002. [CrossRef]
  • 11. Sarli B, Baktir AO, Saglam H, Arinc H, Kurtul S, Sivgin S, et al. Neutrophil-to-Lymphocyte Ratio is Associated With Severity of Coronary Artery Ectasia. Angiology 2014;65:147-51. [CrossRef]
  • 12. Azab B, Zaher M, Weiserbs KF, Torbey E, Lacossiere K, Gaddam S, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol 2010;106:470-6. [CrossRef]
  • 13. Ates AH, Canpolat U, Yorgun H, Kaya EB, Sunman H, Demiri E, et al. Total white blood cell count is associated with the presence, severity and extent of coronary atherosclerosis detected by dual-source multislice computed tomographic coronary angiography. Cardiol J 2011;18:371-7.
  • 14. Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 1998;279:1477-82. [CrossRef]
  • 15. Lee CD, Folsom AR, Nieto FJ, Chambless LE, Shahar E, Wolfe DA. White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African– American and White men and women atherosclerosis risk in communities study. Am J Epidemiol 2001;154:758-64. [CrossRef]
  • 16. Mehta J, Dinerman J, Mehta P, Saldeen TG, Lawson D, Donnelly WH, et al. Neutrophil function in ischemic heart disease. Circulation 1989;79:549-56. [CrossRef]
  • 17. Baldus S, Heeschen C, Meinertz T, Zeiher AM, Eiserich JP, Munzel T, et al. Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation 2003;108:14. [CrossRef]
  • 18. Hansen PR. Role of neutrophils in myocardial ischemia and reperfusion. Circulation 1995;91:1872-85. [CrossRef]
  • 19. Avanzas P, Quiles J, Lopez de Sa E, Sanchez A, Rubio R, Garcia E, et al. Neutrophil count and infarct size in patients with acute myocardial infarction. Int J Cardiol 2004;97:155-6. [CrossRef]
  • 20. Kirtane AJ, Bui A, Murphy SA, Barron HV, Gibson CM. Association of peripheral neutrophilia with adverse angiographic outcomes in ST elevation myocardial infarction. Am J Cardiol 2004;93:532-6. [CrossRef]
  • 21. Ommen SR, Gibbons RJ, Hodge DO, Thomson SP. Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease. Am J Cardiol 1997;79:812-4. [CrossRef]
  • 22. Ommen SR, Hodge DO, Rodeheffer RJ, McGregor CG, Thomson SP, Gibbons RJ. Predictive power of the relative lymphocyte Demir et al. Usefulness of NLR in Kawasaki Disease 375 concentration in patients with advanced heart failure. Circulation 1998;97:19-22. [CrossRef]
  • 23. Takahashi M, Newburger JW. Kawasaki Syndrome (Mucocutaneous Lymph Node Syndrome). In: Allen HD, Driscoll DJ, Shaddy RE, Feltes TF, editors. Moss and Adams’ Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2008:1242-55.
  • 24. Takahashi K, Oharaseki T, Yokouchi Y, Naoe S, Saji T. Kawasaki disease: basic and pathological findings. Clin Exp Nephrol 2013:17:690-3. [CrossRef]
  • 25. Suzuki A, Miyagawa-Tomita S, Komatsu K, Nishikawa T, Sakomura Y, Horie T, et al. Active remodeling of the coronary arterial lesions in the late phase of Kawasaki disease: immunohistochemical study. Circulation 2000;101:2935-41. [CrossRef]
  • 26. Sonobe T, Kiyosawa N, Tsuchiya K, Aso S, Imada Y, Imai Y, et al. Prevalence of coronary artery abnormality in incomplete Kawasaki disease. Pediatr Int 2007;49:421-6. [CrossRef]
  • 27. Aydin M, Tekin IO, Dogan SM, Yildirim N, Arasli M, Sayin MR, et al. The levels of tumor necrosis factor-alpha and interleukin-6 in patients with isolated coronary artery ectasia. Mediators Inflamm 2009;106145. [CrossRef]
  • 28. Kajinami K, Kasashima S, Oda Y, Koizumi J, Katsuda S, Mabuchi H. Coronary ectasia in familial hypercholesterolemia: a histopathological study regarding matrix metalloproteinases. Mod Pathol 1999;12:1174-80.
  • 29. Li JJ, Li Z, Li J. Is any link between inflammation and coronary artery ectasia? Med Hypotheses 2007;69:678-83. [CrossRef] 30. Kalaycıoğlu E, Gökdeniz T, Aykan AC, Gül I, Boyacı F, Gürsoy OM, et al. Comparison of neutrophil to lymphocyte ratio in patients with coronary artery ectasia versus patients with obstructive coronary artery disease. Kardiol Pol 2014;72:372-80. [CrossRef

Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease

Year 2015, Volume: 32 Issue: 4, 371 - 376, 01.10.2015

Abstract

Background: Kawasaki disease is an inflammatory condition. Neutrophil to lymphocyte ratio is a marker reflecting inflammation. Aims: The aim of the study is to evaluate usefulness of neutrophil to lymphocyte ratio in diagnosis of Kawasaki disease and in prediction of coronary artery lesions. Study Design: Retrospective cross-sectional study. Methods: Seventy-five children with Kawasaki disease and 66 controls were retrospectively enrolled. Their leukocyte, neutrophil, and lymphocyte counts were recorded. Abnormally distributed data were shown as median (interquartile range). Cases having coronary artery diameter two standard deviation above mean were diagnosed to have coronary artery lesions. Results: Median age of Kawasaki disease patients was 34 months. Twentyfive of those (33.33%) had incomplete Kawasaki disease and twenty-six (34.66%) had coronary artery lesions. Leukocyte [12.61 (6.09)x103/µL vs. 8.48 (5.58)x103/µL], neutrophil [6.73 (4.10)x103/µL vs. 4.62 (5.47)x103/µL], and lymphocyte [4.04 (2.91)x103/µL vs. 3.02 (2.57)x103/µL] counts were significantly higher in Kawasaki disease patients compared to controls (all p values <0.01). However, there was not significant difference between patients and controls regarding neutrophil to lymphocyte ratio [1.72 (1.22) vs. 1.71 (1.88)]. Findings of Kawasaki disease and incomplete Kawasaki disease cases did not differ, while comparison of patients with and without coronary artery lesions revealed significantly higher neutrophil to lymphocyte ratio values in former group [2.02 (1.63) vs. 1.50 (1.28), p=0.01]. The cut-off neutrophil to lymphocyte ratio value for prediction of coronary artery lesions was determined as 1.32. Conclusion: Neutrophil to lymphocyte ratio values in Kawasaki patients with coronary lesions were significantly higher than the ones without and values greater than 1.32 were useful in prediction of coronary lesions.

References

  • 1. Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics 1974;54:271-6.
  • 2. Kato H, Ichinose E, Yoshioka F, Takechi T, Matsunaga S, Suziki K, et al. Fate of coronary aneurysms in Kawasaki disease: serial coronary angiography and long-term follow-up study. Am J Cardiol 1982;49:1758-66. [CrossRef]
  • 3. Huang WC, Huang LM, Chang IS, Chang LY, Chiang BL, Chen PJ, et al. Epidemiologic features of Kawasaki disease in Taiwan, 2003-2006. Pediatrics 2009;123:e401-5. [CrossRef]
  • 4. Nakamura Y, Yashiro M, Uehara R, Oki I, Kayaba K, Yanagawa H. Increasing incidence of Kawasaki disease in Japan: nationwide survey. Pediatr Int 2008;50:287-90. [CrossRef]
  • 5. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et al. Diagnosis, treatment and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004;110:2747-71. [CrossRef]
  • 6. Perrin L, Letierce A, Guitton C, Tran TA, Lambert V, Kone-Paut I. Comparative study of complete versus incomplete Kawasaki disease in 59 pediatric patients. Joint Bone Spine 2009;76:481-5. [CrossRef]
  • 7. Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:55-9. [CrossRef]
  • 8. Gökhan S, Ozhasenekler A, Mansur Durgun H, Akil E, Ustündag M, Orak M. Neutrophil lymphocyte ratios in stroke subtypes and transient ischemic attack. Eur Rev Med Pharmacol Sci 2013;17:653-7.
  • 9. Yoon NB, Son C, Um SJ. Role of the neutrophil-lymphocyte count ratio in the differential diagnosis between pulmonary tuberculosis and bacterial community-acquired pneumonia. Ann Lab Med 2013;33:105-10. [CrossRef]
  • 10. Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J 2007;154:995-1002. [CrossRef]
  • 11. Sarli B, Baktir AO, Saglam H, Arinc H, Kurtul S, Sivgin S, et al. Neutrophil-to-Lymphocyte Ratio is Associated With Severity of Coronary Artery Ectasia. Angiology 2014;65:147-51. [CrossRef]
  • 12. Azab B, Zaher M, Weiserbs KF, Torbey E, Lacossiere K, Gaddam S, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction. Am J Cardiol 2010;106:470-6. [CrossRef]
  • 13. Ates AH, Canpolat U, Yorgun H, Kaya EB, Sunman H, Demiri E, et al. Total white blood cell count is associated with the presence, severity and extent of coronary atherosclerosis detected by dual-source multislice computed tomographic coronary angiography. Cardiol J 2011;18:371-7.
  • 14. Danesh J, Collins R, Appleby P, Peto R. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 1998;279:1477-82. [CrossRef]
  • 15. Lee CD, Folsom AR, Nieto FJ, Chambless LE, Shahar E, Wolfe DA. White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African– American and White men and women atherosclerosis risk in communities study. Am J Epidemiol 2001;154:758-64. [CrossRef]
  • 16. Mehta J, Dinerman J, Mehta P, Saldeen TG, Lawson D, Donnelly WH, et al. Neutrophil function in ischemic heart disease. Circulation 1989;79:549-56. [CrossRef]
  • 17. Baldus S, Heeschen C, Meinertz T, Zeiher AM, Eiserich JP, Munzel T, et al. Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation 2003;108:14. [CrossRef]
  • 18. Hansen PR. Role of neutrophils in myocardial ischemia and reperfusion. Circulation 1995;91:1872-85. [CrossRef]
  • 19. Avanzas P, Quiles J, Lopez de Sa E, Sanchez A, Rubio R, Garcia E, et al. Neutrophil count and infarct size in patients with acute myocardial infarction. Int J Cardiol 2004;97:155-6. [CrossRef]
  • 20. Kirtane AJ, Bui A, Murphy SA, Barron HV, Gibson CM. Association of peripheral neutrophilia with adverse angiographic outcomes in ST elevation myocardial infarction. Am J Cardiol 2004;93:532-6. [CrossRef]
  • 21. Ommen SR, Gibbons RJ, Hodge DO, Thomson SP. Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease. Am J Cardiol 1997;79:812-4. [CrossRef]
  • 22. Ommen SR, Hodge DO, Rodeheffer RJ, McGregor CG, Thomson SP, Gibbons RJ. Predictive power of the relative lymphocyte Demir et al. Usefulness of NLR in Kawasaki Disease 375 concentration in patients with advanced heart failure. Circulation 1998;97:19-22. [CrossRef]
  • 23. Takahashi M, Newburger JW. Kawasaki Syndrome (Mucocutaneous Lymph Node Syndrome). In: Allen HD, Driscoll DJ, Shaddy RE, Feltes TF, editors. Moss and Adams’ Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2008:1242-55.
  • 24. Takahashi K, Oharaseki T, Yokouchi Y, Naoe S, Saji T. Kawasaki disease: basic and pathological findings. Clin Exp Nephrol 2013:17:690-3. [CrossRef]
  • 25. Suzuki A, Miyagawa-Tomita S, Komatsu K, Nishikawa T, Sakomura Y, Horie T, et al. Active remodeling of the coronary arterial lesions in the late phase of Kawasaki disease: immunohistochemical study. Circulation 2000;101:2935-41. [CrossRef]
  • 26. Sonobe T, Kiyosawa N, Tsuchiya K, Aso S, Imada Y, Imai Y, et al. Prevalence of coronary artery abnormality in incomplete Kawasaki disease. Pediatr Int 2007;49:421-6. [CrossRef]
  • 27. Aydin M, Tekin IO, Dogan SM, Yildirim N, Arasli M, Sayin MR, et al. The levels of tumor necrosis factor-alpha and interleukin-6 in patients with isolated coronary artery ectasia. Mediators Inflamm 2009;106145. [CrossRef]
  • 28. Kajinami K, Kasashima S, Oda Y, Koizumi J, Katsuda S, Mabuchi H. Coronary ectasia in familial hypercholesterolemia: a histopathological study regarding matrix metalloproteinases. Mod Pathol 1999;12:1174-80.
  • 29. Li JJ, Li Z, Li J. Is any link between inflammation and coronary artery ectasia? Med Hypotheses 2007;69:678-83. [CrossRef] 30. Kalaycıoğlu E, Gökdeniz T, Aykan AC, Gül I, Boyacı F, Gürsoy OM, et al. Comparison of neutrophil to lymphocyte ratio in patients with coronary artery ectasia versus patients with obstructive coronary artery disease. Kardiol Pol 2014;72:372-80. [CrossRef
There are 29 citations in total.

Details

Other ID JA92VG47YN
Journal Section Research Article
Authors

Fikri Demir This is me

Cem Karadeniz This is me

Rahmi Özdemir This is me

Yılmaz Yozgat This is me

Kübra Çelegen This is me

Utku Karaaslan This is me

Mustafa Demirol This is me

Timur Meşe This is me

Nurettin Ünal This is me

Publication Date October 1, 2015
Published in Issue Year 2015 Volume: 32 Issue: 4

Cite

APA Demir, F., Karadeniz, C., Özdemir, R., Yozgat, Y., et al. (2015). Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease. Balkan Medical Journal, 32(4), 371-376.
AMA Demir F, Karadeniz C, Özdemir R, Yozgat Y, Çelegen K, Karaaslan U, Demirol M, Meşe T, Ünal N. Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease. Balkan Medical Journal. October 2015;32(4):371-376.
Chicago Demir, Fikri, Cem Karadeniz, Rahmi Özdemir, Yılmaz Yozgat, Kübra Çelegen, Utku Karaaslan, Mustafa Demirol, Timur Meşe, and Nurettin Ünal. “Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients With Kawasaki Disease”. Balkan Medical Journal 32, no. 4 (October 2015): 371-76.
EndNote Demir F, Karadeniz C, Özdemir R, Yozgat Y, Çelegen K, Karaaslan U, Demirol M, Meşe T, Ünal N (October 1, 2015) Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease. Balkan Medical Journal 32 4 371–376.
IEEE F. Demir, C. Karadeniz, R. Özdemir, Y. Yozgat, K. Çelegen, U. Karaaslan, M. Demirol, T. Meşe, and N. Ünal, “Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease”, Balkan Medical Journal, vol. 32, no. 4, pp. 371–376, 2015.
ISNAD Demir, Fikri et al. “Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients With Kawasaki Disease”. Balkan Medical Journal 32/4 (October 2015), 371-376.
JAMA Demir F, Karadeniz C, Özdemir R, Yozgat Y, Çelegen K, Karaaslan U, Demirol M, Meşe T, Ünal N. Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease. Balkan Medical Journal. 2015;32:371–376.
MLA Demir, Fikri et al. “Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients With Kawasaki Disease”. Balkan Medical Journal, vol. 32, no. 4, 2015, pp. 371-6.
Vancouver Demir F, Karadeniz C, Özdemir R, Yozgat Y, Çelegen K, Karaaslan U, Demirol M, Meşe T, Ünal N. Usefulness of Neutrophil to Lymphocyte Ratio in Prediction of Coronary Artery Lesions in Patients with Kawasaki Disease. Balkan Medical Journal. 2015;32(4):371-6.