Epigallokateşin Gallatın (EGCG) Parkinson Hastalığı Patogenezinde Potansiyel Koruyucu Etkileri

Year 2024, Volume: 6 Issue: 2, 427 - 435

Elif Yıldız , İlknur Gökçe Yıldırım

https://doi.org/10.46413/boneyusbad.1415742

Abstract

Bu derlemenin amacı, epigallokateşin gallatın Parkinson hastalığı patogenezi üzerindeki koruyucu etkilerini incelemektir. Son yıllarda yapılan epidemiyolojik çalışmalarda Parkinson hastalığının artış gösterdiği ve son 25 yılda ikiye katlandığı vurgulanmaktadır. Bundan dolayı hastalığın patogenezine etki edebilen faktörleri değerlendirmek önem kazanmaktadır. Yapılan çalışmalarda vücutta meydana gelen oksidatif stres, inflamasyon ve α-sinüklein proteinin anormal agregasyonu gibi faktörlerin Parkinson’un patogenezinde rol oynadığı saptanmıştır. Çay bileşenlerinden epigallokateşin gallat antiinflamatuar özelliği, oksidatif stres ve α-sinüklein kaynaklı hasara karşı koruyucu etkisi ile Parkinson’un patogeneziyle ilişkili olabilmektedir. Sonuç olarak, epigallokateşin gallatın Parkinson üzerindeki koruyucu etkisine yönelik klinik araştırmalar azdır. Gelecek araştırmalarda daha fazla kanıta dayalı klinik çalışmalarla epigallokateşin gallatın Parkinson üzerindeki etkinliği değerlendirilebilir.

Keywords

Parkinson hastalığı, Epigallokateşin gallat (EGCG), İnflamasyon, Oksidatif stres, Alfa-sinüklein

Potential Protective Effects of Epigallocatechin Gallate (EGCG) on Parkinson's Disease Pathogenesis

Abstract

The aim of this review is to examine the protective effects of epigallocatechin gallate on the pathogenesis of Parkinson's disease. Epidemiological studies conducted in recent years emphasize that Parkinson's disease has increased and has doubled in the last 25 years. Therefore, it becomes important to evaluate the factors that may affect the pathogenesis of the disease. Studies have found that factors such as oxidative stress, inflammation and abnormal aggregation of α-synuclein protein occurring in the body play a role in the pathogenesis of Parkinson's. Epigallocatechin gallate, one of the tea components, may be related to the pathogenesis of Parkinson's with its anti-inflammatory properties and protective effect against oxidative stress and α-synuclein-induced damage. As a result, clinical studies on the protective effect of epigallocatechin gallate on Parkinson's disease are scarce. In future research, the effectiveness of epigallocatechin gallate on Parkinson's disease can be evaluated with more evidence-based clinical studies.

Keywords

Parkinson disease, Epigallocatechin gallate (EGCG), Inflamation, Oxidative stress, Alpha-synuclein

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