Akut Pulmoner Emboli'de Galectin-3

- , 01.03.2020

Mustafa Çelik , Ahmet Avcı Recep Karataş Ahmet Erseçgin Fikret Keleş Ahmet Yılmaz , Fatmagül Can Erdoğan Sökmen , Murat Erer

https://doi.org/10.16919/bozoktip.526355

Cited By: 1

Abstract

Amaç: Pulmoner
emboli (PE) göreceli olarak yaygın bir kardiyovasküler acil durumdur ve
spesifik olmayan klinik tablo nedeniyle gözden kaçırılabilecek zor bir tanıdır.
PE' nin patogenezi iyi tanımlanmış olmasına rağmen, PE' nin teşhisine yardımcı
olabilecek klinik bir biyobelirteçlere ihtiyaç vardır. Teorik olarak,
Galectin-3'ün (Gal-3) prokoagülan etkisinden dolayı,  PE'nin patogenezindeki  rol alabileceği düşünülebilir. Bu çalışmanın
amacı, akut PE'li hastalarda Gal-3 düzeyinin önemini göstermek ve PE'nin
ekokardiyografik özellikleri ile ilişkiyi tanımlamaktır.

 Yöntem:  2013 - 2014 tarihleri ​​arasında art arda 40
PE hastası (26 kadın, ort. Yaş 60.93 ± 14.28 yıl) ve 40 yaş uyumlu sağlıklı
kontrol çalışmaya dahil edildi. Gal-3, D-dimer ve Troponin I ölçüldü. PE ve
kontrol grubundaki tüm hastalara transtorasik ekokardiyografik inceleme
yapıldı.

 Bulgular:
Gal-3 ve D-dimer düzeyleri PE' li hastalarda kontrollere göre anlamlı derecede
yüksek bulundu (17.04 ± 6.6 ve 8.22 ± 4.9, p <0.001). Gal-3 seviyeleri, D- dimer
 (r = 0.595, p <0.001) ve Troponin I
değerleri (r = 0.452, p <0.001) ile anlamlı bir korelasyon gösterdi. Gal-3
seviyeleri ekokardiyografik parametrelerle anlamlı korelasyon gösterdi. ROC eğrisi
analizinde,% 82.5 duyarlılık ve% 82.7 özgüllük ile akut PE tanısı için gereken
seviye 11.43 ng / ml idi. Eğri altındaki alan% 95 CI 0.79-0.96 (p <0.001)
ile 0.88 idi.

Sonuç: Bu
çalışmada akut PE'li hastalarda Gal-3'ün rolü gösterilmiştir. Gal-3, akut PE' yi
teşhis etmek için kullanılabilecek biyobelirteçler arasında yer alabilir.ancak
daha kapsamlı çalışmalara ihtiyaç vardır.

Keywords

Galectin-3, D-dimer, Akut pulmoner emboli, Biyobelirteç, Ekokardiyografi

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