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Which Imaging Method to Choose for Detection of Bone Metastases? Bone Scintigraphy, CT, 18F-FDG PET/CT or MR?

Year 2013, Volume: 3 Issue: 3, 44 - 50, 01.09.2013

Abstract

Bone metastases are a common complication of cancer. Skeletal metastases are clinically significant because of associated symptoms, complications such as pathological fracture significance for staging, treatment and prognosis. Detection of bone metastases is, thus, an important part of treatment plannning. Four main modalities are available clinically: radiography, CT scan, nuclear imaging (Technetium-99m labeled diphosphonates and 18F- FDG PET/CT) and magnetic resonance imaging. In this review, we discuss these imaging technics and recommend imaging strategies for the detection of bone metastases.

References

  • Kılıçkap S, Taptan Ü, Yalçın S. Metastasis to Bone from Gastric Cancer: A Single Centre Experience. Cumhuriyet Med J 2010;32:192-8.
  • Metler FA, Guiberteau MJ. Essentials of Nuclear Medicine Imaging. Chapter 8. Skeletal System. 6th ed. Elsevier Inc 2012;271-314.
  • Andreula C, Murrone M. Metastatic Disease of the Spine. Eur Radiol 2005;15:627-32.
  • Taoka T, Mayr NA, Lee HJ, Yuh WT, Simonson TM, Rezai K, Berbaum KS. Factors influencing visualization of Vertebral Metastases on MR Imaging versus Bone Scintigraphy. AJR Am J Roentgenol 2001; 176(6):1525
  • Tins BJ, Lalam RK, Cassar-Pullicino VN, Tyrrell PNM. Bone Metastases 2: Pelvis and Appendicular Skelton. Chapter 27. In: Davies AM, Sundaram M, James SLJ (eds). Imaging of Bone Tumors and Tumor-Like Lesions. Springer-Verlag Berlin Heidelberg 2009:48250
  • Choi J, Raghavan M. Diagnostic Imaging and ImageGuide Therapy of Skeletal Metastases. Cancer Control 2012;19(2):102-12.
  • Tyrrell PNM, Cassar-Pullicino VN, Lalam RK, Tins BJ. Bone Metastases 1: Spine. Chapter 26. In: Davies AM, Sundaram M, James SLJ (eds). Imaging of Bone Tumors and Tumor-Like Lesions. Springer-Verlag Berlin Heidelberg 2009:461-79.
  • Gonzáles-Sistal A, Sánchez AB, Carnero MH, Morell ÁR. Advances in Medical Imaging Applied to Bone Metastases. Medical Imaging 2011:339-54.
  • Yang HL, Liu T, Wang XM, Yu Y, Deng SM. Diagnosis of Bone Metastases: a Meta-analysis comparing 18FDG PET, CT, MRI and Bone Scintigraphy. Eur Radiol 20 21:2604-17.
  • Gandage SG, Kachewar SG, Aironi VD, Nagapurkar AD. A comparative Study of Whloe Body DWIBS MRI versus Bone Scan for Evaluating Skeletal Metastases. Australas Med J 2012;5(12):619-22.
  • Qu X, Huang X, Yan W, Wu L, Dai K. A Metaanalysis of 18FDG-PET-CT, 18FDG-PET, MRI and Bone Scintigraphy for Diagnosis of Bone Metastases in Patients with Lung Cancer. Eur J Radiol 2012;81(5):1007-15.
  • Nagamachi S, Wakamatsu H, Kiyohara S, Nishii R, Mizutani Y, Fujita S, et al. Comparison of Diagnostic and Prognostic Capabilities of 18F-FDG-PET/CT, 131I-scintigraphy, and Diffusion-Weighted Magnetic Resonance Imaging for Postoperative Thyroid Cancer. Jpn J Radiol 2011,29:413-22.
  • Liu T, Cheng T, Xu W, Yan WL, Liu J, Yang HL. A Meta-analysis of 18FFDG-PET, MRI and Bone Scintigraphy for Diagnosis of Bone Metastases in Patients with Breast Cancer. Skeletal Radiol 2011;40:523-31
  • Zamagni E, Nanni C, Patriarca F, Englaro E, Castelluci P, Geatti O, et al. A Prospective Comparision of 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography, Magnetic Resonance Imaging and Whole-body Planar Radiographs in the Assessmnet of Bone Disease in Newly Diagnosed Multiple Myeloma. Haematlogica 2007;92:50-5.
  • Jouvet JC, Thomas L, Thomson V, Yanes M, Journe C, Morelec I, et al. Whole-body MRI with Diffusionweighted Sequences Compared with 18FDG PET-CT, CT and Superficial Lymph Node Ultrasonography in the Staging of Advanced Cutaneous Melanoma: A Prospective Study. J Eur Acad Dermatol Venereol 2013 doi: 1111/jdv.12078.
  • Costelloe CM, Rohren EM, Madewll JE, Hamaoka T, Theriault RL, Yu TK, et al. Imaging Bone Metastases in Breast Cancer: Techniques and Recommendations for Diagnosis. Lancet Oncol 2009;10(6):606-14.
  • Kobayashi M, Okabayashi T, Sano T, Araki K. Metastatic bone cancer as a recurrence of early gastric cancer-- characteristics and possible mechanisms. World J Gastroenterol 2005, 28;11(36):5587-91.
  • Rybak LD, Rosenthal DI. Radiological Imaging for the Diagnosis of Bone Metastases. Q J Nucl Med 2001:53-64.
  • Lecouvet FE, Larbi A, Pasoglou V, Omoumi P, Tombal B, Michoux N, et al. MRI for response assessment in metastatic bone disease. Eur Radiol 2013;23(7):1986-97.
  • Zhang Y, Zhao C, Liu H, Hou H, Zhang H. Multiple Metastasis-Like Bone Lesions in Scintigraphic Imaging. J Biomed Biotechnol 2012; doi: 10.1155/2012/957364.
  • Jiang L, Han L, Tan H, Hu P, Zhang Y, Shi H. Diagnostic Value of 99mTc-MDP SPECT/spiral CT in Assessing Indeterminate Spinal Solitary Lesion of Patients Without Malignant History. Ann Nucl Med 2013;27(5):460-7.
  • Fox JJ, Schöder H, Larson SM. Prostat Kanserinin Moleküler Görüntülemesi. Current Opinion in Urology 2012; 5(3):153-62.
  • Evangelista L, Panunzio A, Polverosi R, Ferretti A, Chondrogiannis S, Pomerri F, et al. Early Bone Marrow Metastasis Detectinon: The Additional Value of FDG-PET/CT vs. CT Imaging. Biomed Pharmacother 2012;66(6):448-53.
  • Cook GJ, Houston S, Rubens R, Maisey MN, Fogelman I. Detection of Bone Metastases in Breast Cancer by 18FDG PET: differing Metabolic Activity in Osteoblastic and Osteolytic Lesions. J Clin Oncol 1998;16(10):3375-9.
  • Even-Sapir E, Metser U, Mishani E, Lievshitz G, Lerman H, Leibovitch I. The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18Ffluoride PET/CT. J Nucl Med 2006;47(2):287-97.
  • Even-Sapir E. Imaging of Malignant Bone Involvement by Morphologic, Scintigraphic, and Hybrid Modalities. J Nucl Med 2005;46(8):1356-67. van der Horst G, van der Pluijm G. Preclinical imaging and molecular events in the multistep process of bone metastasis. Future Oncol 2012;8(4):415-30.
  • Launstein TC, Goehde SC, Herborn CU, Goyen M, Oberhoff C, Debatin JF, et al. Whole-Body MR Imaging: Evaluation of Patients for Metastases. Radiology 2004;233(1):139-48.
  • Stecco A, Lombardi M, Leva L, Brambilla M, Negru E, Delli Passeri S, Carriero A. Diagnostic Accuracy and Agreement Between Whole-body Diffusion MRI and Bone Scintigraphy in Detecting Bone Metastases. Radiol Med 2013;118(3):465-75.
  • Baur-Melnyk A, Reiser MF. Role of MDCT in Bone Tumors, Metastases, Myeloma. Chapter 35. In: Reise MF, Becker CR, Nikolaou K, Glazer G (eds). MultiSlice CT. Springer-Verlag Berlin Heidelberg 2009:481-93. 50

KEMİK METASTAZLARININ TESPİTİNDE HANGİ GÖRÜNTÜLEME YÖNTEMİNİ SEÇELİM? KEMİK SİNTİGRAFİSİ, BT, 18F-FDG PET/BT VEYA MR?

Year 2013, Volume: 3 Issue: 3, 44 - 50, 01.09.2013

Abstract

Kemik metastazları kanserin sık görülen bir komplikasyonudur. Kemik metastazları klinik olarak önemlidir, çünkü ilişkili semptomlar, patolojik fraktür gibi komplikasyonlar evrele- me, tedavi ve prognoz için önemlidir. Bu yüzden, kemik metastazının deteksiyonu tedavi planının önemli bir parçasıdır. Dört asıl modalite klinik olarak kullanılır: radyografi, BT gö- rüntüleme, nükleer görüntüleme (Teknesyum-99m ile işaretli kemik sintigrafisi ve 18F- FDG PET/CT) ve manyetik rezonans görüntülemedir. Biz bu derlemede, kemik metastazla- rının deteksiyonu için bu görüntüleme tekniklerini ve önerilen görüntüleme stratejilerini tartıştık.

References

  • Kılıçkap S, Taptan Ü, Yalçın S. Metastasis to Bone from Gastric Cancer: A Single Centre Experience. Cumhuriyet Med J 2010;32:192-8.
  • Metler FA, Guiberteau MJ. Essentials of Nuclear Medicine Imaging. Chapter 8. Skeletal System. 6th ed. Elsevier Inc 2012;271-314.
  • Andreula C, Murrone M. Metastatic Disease of the Spine. Eur Radiol 2005;15:627-32.
  • Taoka T, Mayr NA, Lee HJ, Yuh WT, Simonson TM, Rezai K, Berbaum KS. Factors influencing visualization of Vertebral Metastases on MR Imaging versus Bone Scintigraphy. AJR Am J Roentgenol 2001; 176(6):1525
  • Tins BJ, Lalam RK, Cassar-Pullicino VN, Tyrrell PNM. Bone Metastases 2: Pelvis and Appendicular Skelton. Chapter 27. In: Davies AM, Sundaram M, James SLJ (eds). Imaging of Bone Tumors and Tumor-Like Lesions. Springer-Verlag Berlin Heidelberg 2009:48250
  • Choi J, Raghavan M. Diagnostic Imaging and ImageGuide Therapy of Skeletal Metastases. Cancer Control 2012;19(2):102-12.
  • Tyrrell PNM, Cassar-Pullicino VN, Lalam RK, Tins BJ. Bone Metastases 1: Spine. Chapter 26. In: Davies AM, Sundaram M, James SLJ (eds). Imaging of Bone Tumors and Tumor-Like Lesions. Springer-Verlag Berlin Heidelberg 2009:461-79.
  • Gonzáles-Sistal A, Sánchez AB, Carnero MH, Morell ÁR. Advances in Medical Imaging Applied to Bone Metastases. Medical Imaging 2011:339-54.
  • Yang HL, Liu T, Wang XM, Yu Y, Deng SM. Diagnosis of Bone Metastases: a Meta-analysis comparing 18FDG PET, CT, MRI and Bone Scintigraphy. Eur Radiol 20 21:2604-17.
  • Gandage SG, Kachewar SG, Aironi VD, Nagapurkar AD. A comparative Study of Whloe Body DWIBS MRI versus Bone Scan for Evaluating Skeletal Metastases. Australas Med J 2012;5(12):619-22.
  • Qu X, Huang X, Yan W, Wu L, Dai K. A Metaanalysis of 18FDG-PET-CT, 18FDG-PET, MRI and Bone Scintigraphy for Diagnosis of Bone Metastases in Patients with Lung Cancer. Eur J Radiol 2012;81(5):1007-15.
  • Nagamachi S, Wakamatsu H, Kiyohara S, Nishii R, Mizutani Y, Fujita S, et al. Comparison of Diagnostic and Prognostic Capabilities of 18F-FDG-PET/CT, 131I-scintigraphy, and Diffusion-Weighted Magnetic Resonance Imaging for Postoperative Thyroid Cancer. Jpn J Radiol 2011,29:413-22.
  • Liu T, Cheng T, Xu W, Yan WL, Liu J, Yang HL. A Meta-analysis of 18FFDG-PET, MRI and Bone Scintigraphy for Diagnosis of Bone Metastases in Patients with Breast Cancer. Skeletal Radiol 2011;40:523-31
  • Zamagni E, Nanni C, Patriarca F, Englaro E, Castelluci P, Geatti O, et al. A Prospective Comparision of 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography, Magnetic Resonance Imaging and Whole-body Planar Radiographs in the Assessmnet of Bone Disease in Newly Diagnosed Multiple Myeloma. Haematlogica 2007;92:50-5.
  • Jouvet JC, Thomas L, Thomson V, Yanes M, Journe C, Morelec I, et al. Whole-body MRI with Diffusionweighted Sequences Compared with 18FDG PET-CT, CT and Superficial Lymph Node Ultrasonography in the Staging of Advanced Cutaneous Melanoma: A Prospective Study. J Eur Acad Dermatol Venereol 2013 doi: 1111/jdv.12078.
  • Costelloe CM, Rohren EM, Madewll JE, Hamaoka T, Theriault RL, Yu TK, et al. Imaging Bone Metastases in Breast Cancer: Techniques and Recommendations for Diagnosis. Lancet Oncol 2009;10(6):606-14.
  • Kobayashi M, Okabayashi T, Sano T, Araki K. Metastatic bone cancer as a recurrence of early gastric cancer-- characteristics and possible mechanisms. World J Gastroenterol 2005, 28;11(36):5587-91.
  • Rybak LD, Rosenthal DI. Radiological Imaging for the Diagnosis of Bone Metastases. Q J Nucl Med 2001:53-64.
  • Lecouvet FE, Larbi A, Pasoglou V, Omoumi P, Tombal B, Michoux N, et al. MRI for response assessment in metastatic bone disease. Eur Radiol 2013;23(7):1986-97.
  • Zhang Y, Zhao C, Liu H, Hou H, Zhang H. Multiple Metastasis-Like Bone Lesions in Scintigraphic Imaging. J Biomed Biotechnol 2012; doi: 10.1155/2012/957364.
  • Jiang L, Han L, Tan H, Hu P, Zhang Y, Shi H. Diagnostic Value of 99mTc-MDP SPECT/spiral CT in Assessing Indeterminate Spinal Solitary Lesion of Patients Without Malignant History. Ann Nucl Med 2013;27(5):460-7.
  • Fox JJ, Schöder H, Larson SM. Prostat Kanserinin Moleküler Görüntülemesi. Current Opinion in Urology 2012; 5(3):153-62.
  • Evangelista L, Panunzio A, Polverosi R, Ferretti A, Chondrogiannis S, Pomerri F, et al. Early Bone Marrow Metastasis Detectinon: The Additional Value of FDG-PET/CT vs. CT Imaging. Biomed Pharmacother 2012;66(6):448-53.
  • Cook GJ, Houston S, Rubens R, Maisey MN, Fogelman I. Detection of Bone Metastases in Breast Cancer by 18FDG PET: differing Metabolic Activity in Osteoblastic and Osteolytic Lesions. J Clin Oncol 1998;16(10):3375-9.
  • Even-Sapir E, Metser U, Mishani E, Lievshitz G, Lerman H, Leibovitch I. The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18Ffluoride PET/CT. J Nucl Med 2006;47(2):287-97.
  • Even-Sapir E. Imaging of Malignant Bone Involvement by Morphologic, Scintigraphic, and Hybrid Modalities. J Nucl Med 2005;46(8):1356-67. van der Horst G, van der Pluijm G. Preclinical imaging and molecular events in the multistep process of bone metastasis. Future Oncol 2012;8(4):415-30.
  • Launstein TC, Goehde SC, Herborn CU, Goyen M, Oberhoff C, Debatin JF, et al. Whole-Body MR Imaging: Evaluation of Patients for Metastases. Radiology 2004;233(1):139-48.
  • Stecco A, Lombardi M, Leva L, Brambilla M, Negru E, Delli Passeri S, Carriero A. Diagnostic Accuracy and Agreement Between Whole-body Diffusion MRI and Bone Scintigraphy in Detecting Bone Metastases. Radiol Med 2013;118(3):465-75.
  • Baur-Melnyk A, Reiser MF. Role of MDCT in Bone Tumors, Metastases, Myeloma. Chapter 35. In: Reise MF, Becker CR, Nikolaou K, Glazer G (eds). MultiSlice CT. Springer-Verlag Berlin Heidelberg 2009:481-93. 50
There are 29 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Review
Authors

Zekiye Hasbek This is me

İsmail Şalk This is me

Birsen Yücel This is me

Nalan Akgül Babacan This is me

Publication Date September 1, 2013
Published in Issue Year 2013 Volume: 3 Issue: 3

Cite

APA Hasbek, Z., Şalk, İ., Yücel, B., Babacan, N. A. (2013). KEMİK METASTAZLARININ TESPİTİNDE HANGİ GÖRÜNTÜLEME YÖNTEMİNİ SEÇELİM? KEMİK SİNTİGRAFİSİ, BT, 18F-FDG PET/BT VEYA MR?. Bozok Tıp Dergisi, 3(3), 44-50.
AMA Hasbek Z, Şalk İ, Yücel B, Babacan NA. KEMİK METASTAZLARININ TESPİTİNDE HANGİ GÖRÜNTÜLEME YÖNTEMİNİ SEÇELİM? KEMİK SİNTİGRAFİSİ, BT, 18F-FDG PET/BT VEYA MR?. Bozok Tıp Dergisi. September 2013;3(3):44-50.
Chicago Hasbek, Zekiye, İsmail Şalk, Birsen Yücel, and Nalan Akgül Babacan. “KEMİK METASTAZLARININ TESPİTİNDE HANGİ GÖRÜNTÜLEME YÖNTEMİNİ SEÇELİM? KEMİK SİNTİGRAFİSİ, BT, 18F-FDG PET/BT VEYA MR?”. Bozok Tıp Dergisi 3, no. 3 (September 2013): 44-50.
EndNote Hasbek Z, Şalk İ, Yücel B, Babacan NA (September 1, 2013) KEMİK METASTAZLARININ TESPİTİNDE HANGİ GÖRÜNTÜLEME YÖNTEMİNİ SEÇELİM? KEMİK SİNTİGRAFİSİ, BT, 18F-FDG PET/BT VEYA MR?. Bozok Tıp Dergisi 3 3 44–50.
IEEE Z. Hasbek, İ. Şalk, B. Yücel, and N. A. Babacan, “KEMİK METASTAZLARININ TESPİTİNDE HANGİ GÖRÜNTÜLEME YÖNTEMİNİ SEÇELİM? KEMİK SİNTİGRAFİSİ, BT, 18F-FDG PET/BT VEYA MR?”, Bozok Tıp Dergisi, vol. 3, no. 3, pp. 44–50, 2013.
ISNAD Hasbek, Zekiye et al. “KEMİK METASTAZLARININ TESPİTİNDE HANGİ GÖRÜNTÜLEME YÖNTEMİNİ SEÇELİM? KEMİK SİNTİGRAFİSİ, BT, 18F-FDG PET/BT VEYA MR?”. Bozok Tıp Dergisi 3/3 (September 2013), 44-50.
JAMA Hasbek Z, Şalk İ, Yücel B, Babacan NA. KEMİK METASTAZLARININ TESPİTİNDE HANGİ GÖRÜNTÜLEME YÖNTEMİNİ SEÇELİM? KEMİK SİNTİGRAFİSİ, BT, 18F-FDG PET/BT VEYA MR?. Bozok Tıp Dergisi. 2013;3:44–50.
MLA Hasbek, Zekiye et al. “KEMİK METASTAZLARININ TESPİTİNDE HANGİ GÖRÜNTÜLEME YÖNTEMİNİ SEÇELİM? KEMİK SİNTİGRAFİSİ, BT, 18F-FDG PET/BT VEYA MR?”. Bozok Tıp Dergisi, vol. 3, no. 3, 2013, pp. 44-50.
Vancouver Hasbek Z, Şalk İ, Yücel B, Babacan NA. KEMİK METASTAZLARININ TESPİTİNDE HANGİ GÖRÜNTÜLEME YÖNTEMİNİ SEÇELİM? KEMİK SİNTİGRAFİSİ, BT, 18F-FDG PET/BT VEYA MR?. Bozok Tıp Dergisi. 2013;3(3):44-50.
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