ROTAVİRUS İNFEKSİYONLARINDA GASTROENTERİT DIŞI BULGULAR Non-Gastroenteritis Findings In Rotavirus Infections
Abstract
ÖZET
Giriş: Rotavirus çocukluk çağında özellikle 5 yaş altı çocuklarda en sık görülen gastroenterit etkenlerinden
birisidir. Gastroenterit yakınmalarının yanında viremiye bağlı ekstra-intestinal patolojiler meydana getirmektedir.
Bu çalışmada amaç çocuk acil ünitemize rotavirus infeksiyonu ile gelen hastalarda sistemik morbidite
ve klinik gidiş üzerine etkilerini ve bunların 2 yıl süreli takibinin değerlendirilmesidir.
Method: 2012-2013 kasım yılları arasında ve 0-18 yaş grubunda 236 hasta çalışmaya alındı. Veriler retrospektif
olarak hasta dosya sistemi ve hastane otomasyonundan alındı. Çalışma retrospektif olarak yapılmıştır.
İstatistik için ise SPSS 21.0 versiyon programı kullanıldı.
Bulgular: Çalışmaya alınan 236 hastanın sadece 5’inde (%2) ciddi derecede dehidratasyon saptandı. Hastaların
çoğunluğunda derecede hafif dehidratasyon mevcuttu. 46 hastada (%23,6) infeksiyon ile ilişkili geçici
lenfopeni saptandı. 22 (%9,3) hastada ise geçici nonikterik hepatit tablosu görüldü. 8 hastada (%3,4) febril
konvülsiyon ve 1(%0,4) hastada konfüzyon ve 8 (%3,4) hastada ise hipoglisemi mevcuttu. Tüm komorbid
durumlar tedavisiz düzeldi ve 2 yıllık takiplerinde kronik ilaç kullanımı veya süregelen hastalık durumu hiçbir
hastada görülmedi. Çalışmaya alınan altta yatan bir kronik hastalığı olanlarda yatış süresinin uzadığı ve hipogliseminin
daha fazla görüldüğü saptandı.
Sonuç: Rotavirus enfeksiyonu gastroenterit yanında mulitorgan etkilenimi oluşturmaktadır. Çalışmamızda
infeksiyon gidişatı sırasında oluşan komorbid durumların benign gidişli, tedavisiz düzelen ve kronik hastalığa
yol açmayan durumlar olduğu saptanmıştır.
Anahtar Kelimeler: Rotavirus; Morbidite; Non-ikterik hepatit; Febril konvülsiyon
ABSTRACT
Introduction: Rotavirus is one of the most common gastroenteritis agents especially in children under 5
years of age. In addition to gastroenteritis, rotavirus is associated with extra-intestinal pathologies caused
by viremia. We examined systemic morbidities and effects on the clinical courses in pediatric patients admitted
to the pediatric emergency unit with rotavirus infection and evaluated these patients over a 2-year
follow-up period.
Methods: 236 patients were included in the study admitting to the pediatric emergency unit between November
2012-2013. Patients are 0-18 years old. Study was performed retrospectively. SPSS version 21 software
was used for analysis.
Results: The majority of patients had mild dehydration. Forty-six patients (23.6%) had transient lymphocytopenia
associated with systemic infection. Temporary non-icteric hepatitis was seen in 22 (9.3%) patients.
Moreover, 8 patients (3.4%) had febrile seizures and 1 patient (0.4%) had confusion and 8 (3.4%) patients
had hypoglycemia. All comorbid conditions were remedied without treatment and in 2 years follow-up
chronic use of medication or ongoing illness was not seen in any patient. Patients with chronic illness were
found to have more prolonged length of stay and were found to have more frequent hypoglycemia. It was
determined that adenovirus coinfection, dehydration degree and other clinical conditions did not affect the
duration of hospital stay and the clinical course.
Conclusion: Rotavirus infection can cause diseases that affect multiple organs. The comorbid conditions that
occurred during the course of gastrointestinal infection had a benign course, improved without the need for
treatment, and did not result in chronic diseases.
Keywords: Rotavirus, morbidity; Non-icteric hepatitis; Febrile seizures
References
- 1. De Zoysa I, Feachem RG. Interventions for the control of diarrhoeal diseases among young children: rotavirus and cholera immunization. Bull World Health Organ 1985;63(3):569-83. 2. Sugata K, Taniguchi K, Yui A, Miyake F, Suga S, Asano Y et al. Analysis of rotavirus antigenemia and extraintestinal manifestations in children with rotavirus gastroenteritis. Pediatrics 2008;122(2):392-97. 3. Chiappini E, Azzari C, Moriondo M, Galli L, Martino M. Viraemia is a common finding in immunocompetent children with rotavirus infection. J Med Virol 2005;76(2):265-67. 4. Rodriguez WJ, Kim HW, Arrobio JO, Galli L, de Martino M. Clinical features of acute gastroenteritis associated with human reovirus-like agent in infants and young children. J Pediatr 1977;91(2):188-93. 5. Bernstein DI. Rotavirus overview. Pediatr Infect Dis J 2009(10);28:50-53. 6. Sarah E, Blutt SE, Matson DO, Crawford SE, Staat MA, Azimi P, et al. Rotavirus antigenemia in children is associated with viremia. PLoS Med 2007;4(4):121. 7. Alfajaro MM, Cho K-O. Evidences and consequences of extra-intestinal spread of rotaviruses in humans and animals. Virusdisease 2014;25(2):186-94. 8. Teitelbaum JE, Daghistani R. Rotavirus causes hepatic transaminase elevation. Dig Dis Sci 2007;52(12):396-98. 9. Contino MF, Lebby T, Arcinue EL. Rotaviral gastrointestinal infection causing afebrile seizures in infancy and childhood. Am J Emerg Med 1994(1);12:94-95. SEÇİLMİŞ ve ark. Rotavirus’ta Gastroenterit Dışı Bulgular Bozok Tıp Derg 2020;10(1):17-23 Bozok Med J 2020;10(1):17-23 10. Bresee J LS, Pickering LK, Prober CG. Diseases. Viral Gastroenteritis. Sarah S. Long Ed, Principles and Practice of Pediatric Infectious. Vol 4. Philadelphia: Elsevier. 2012. p.377-81
Abstract
References
- 1. De Zoysa I, Feachem RG. Interventions for the control of diarrhoeal diseases among young children: rotavirus and cholera immunization. Bull World Health Organ 1985;63(3):569-83. 2. Sugata K, Taniguchi K, Yui A, Miyake F, Suga S, Asano Y et al. Analysis of rotavirus antigenemia and extraintestinal manifestations in children with rotavirus gastroenteritis. Pediatrics 2008;122(2):392-97. 3. Chiappini E, Azzari C, Moriondo M, Galli L, Martino M. Viraemia is a common finding in immunocompetent children with rotavirus infection. J Med Virol 2005;76(2):265-67. 4. Rodriguez WJ, Kim HW, Arrobio JO, Galli L, de Martino M. Clinical features of acute gastroenteritis associated with human reovirus-like agent in infants and young children. J Pediatr 1977;91(2):188-93. 5. Bernstein DI. Rotavirus overview. Pediatr Infect Dis J 2009(10);28:50-53. 6. Sarah E, Blutt SE, Matson DO, Crawford SE, Staat MA, Azimi P, et al. Rotavirus antigenemia in children is associated with viremia. PLoS Med 2007;4(4):121. 7. Alfajaro MM, Cho K-O. Evidences and consequences of extra-intestinal spread of rotaviruses in humans and animals. Virusdisease 2014;25(2):186-94. 8. Teitelbaum JE, Daghistani R. Rotavirus causes hepatic transaminase elevation. Dig Dis Sci 2007;52(12):396-98. 9. Contino MF, Lebby T, Arcinue EL. Rotaviral gastrointestinal infection causing afebrile seizures in infancy and childhood. Am J Emerg Med 1994(1);12:94-95. SEÇİLMİŞ ve ark. Rotavirus’ta Gastroenterit Dışı Bulgular Bozok Tıp Derg 2020;10(1):17-23 Bozok Med J 2020;10(1):17-23 10. Bresee J LS, Pickering LK, Prober CG. Diseases. Viral Gastroenteritis. Sarah S. Long Ed, Principles and Practice of Pediatric Infectious. Vol 4. Philadelphia: Elsevier. 2012. p.377-81
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Research |
| Authors | |
| Publication Date | March 25, 2020 |
| Published in Issue | Year 2020 Volume: 10 Issue: 1 |