Abstract
References
- 1. Devinsky O, Vezzani A, O’Brien TJ, Jette N, Scheffer IE, de Curtis M, et al. Epilepsy. Nature Reviews Disease Primers. 2018;4:18024. 2. Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58:522–530. 3. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016;388:1545–1602. 4. Hesdorffer DC, Logroscino G, Benn EK, Katri N, Cascino G, Hauser WA. Estimating risk for developing epilepsy: a population-based study in Rochester, Minnesota. Neurology. 2011;76(1):23-27. 5. Li G, Bauer S, Nowak M, Norwood B, Björn T, Rosenow F, et al. Cytokines and epilepsy. Seizure. 2011;20:249-256. 6. Xu D, Miller SD, Koh S. Immune mechanisms in epileptogenesis. Frontiers in Cellular Neuroscience. 2013;7(195):1-8. 7. Baykal Y, Karaayvaz M, Kutlu M. Interleukins. Türkiye Klinikleri Tıp Bilimleri Dergisi. 1998;18:77-84. 8. Banks WA, Kastin AJ. Blood to brain transport of interleukin links the immune and central nervous system. Life Sciences. 1991;48:117-121. 9. Gallentine WB, Shinnar S, Hesdorffer DC, Epstein L, Nordli DR Jr, Lewis DV, et al. Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury. Epilepsia. 2017;58(6):1102-1111. 10. Uludag IF, Duksal T, Tiftikcioglu BI, Zorlu Y, Ozkaya F, Kirkali G. IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy. Seizure, 2015;26:22–25
Abstract
ÖZET
Epilepsi yaygın bir kronik nörolojik bozukluktur ve patofizyolojisi pek çok şekilde anlaşılmamıştır. Sitokinler,
periferal dokudaki iltihaplanma sırasında enflamatuar sistem hücreleri arasında iletişim kuran bir grup
çözünür aracıdır. Her ne kadar sitokinlerin epilepsi etiyolojisindeki rolü hakkında bilgi sahibi olsak da, sitokinlerin
epilepside temel fizyopatolojik mekanizmadaki rolü hakkında bilgi sınırlıdır. İnterlökinler (IL) akut
ve kronik inflamasyon ile ilişkilidir ve bağışıklık yanıtında önemli bir rol oynar. Epilepside IL-1β ve IL-6'nın
rollerini anlamak, epileptogenezi anlamak ve klinik tanı ve yeni tedavi seçenekleri geliştirmek için önemlidir.
Bu nedenle, bu çalışmada, IL-1β ve IL-6 sitokinlerinin epilepside rollerini ve yerlerini derlemeye çalıştık.
Anahtar kelimeler: Epilepsi; Sitokinler; IL-1β; IL-6
ABSTRACT
Epilepsy is a common chronic neurological disorder and its pathophysiology has not been understood in
many ways. Cytokines are a group of soluble mediators that communicate between inflammatory system
cells during inflammation in the peripheral tissue. We have information about the role of cytokines in
epilepsy etiology, but information on the role of cytokines in the basic physiopathological mechanism
of epilepsy is limited. IL-1β and IL-6 are associated with acute and chronic inflammation and play an
important role in immune response. Understanding the roles of IL-1β and IL-6 in epilepsy is important for
understanding epileptogenesis and developing clinical diagnosis and new treatment options. Therefore, in
this study, we tried to compile the roles and states of IL-1β and IL-6 cytokines in epilepsy.
Key Words: Epilepsy; Cytokines; IL-1β; IL-6
Keywords
EPİLEPSİ HASTALIĞINDA İL-1β VE İL-6'NIN ROLÜ The Role of IL-1β and IL-6 in Epilepsy Disease
References
- 1. Devinsky O, Vezzani A, O’Brien TJ, Jette N, Scheffer IE, de Curtis M, et al. Epilepsy. Nature Reviews Disease Primers. 2018;4:18024. 2. Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, et al. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58:522–530. 3. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016;388:1545–1602. 4. Hesdorffer DC, Logroscino G, Benn EK, Katri N, Cascino G, Hauser WA. Estimating risk for developing epilepsy: a population-based study in Rochester, Minnesota. Neurology. 2011;76(1):23-27. 5. Li G, Bauer S, Nowak M, Norwood B, Björn T, Rosenow F, et al. Cytokines and epilepsy. Seizure. 2011;20:249-256. 6. Xu D, Miller SD, Koh S. Immune mechanisms in epileptogenesis. Frontiers in Cellular Neuroscience. 2013;7(195):1-8. 7. Baykal Y, Karaayvaz M, Kutlu M. Interleukins. Türkiye Klinikleri Tıp Bilimleri Dergisi. 1998;18:77-84. 8. Banks WA, Kastin AJ. Blood to brain transport of interleukin links the immune and central nervous system. Life Sciences. 1991;48:117-121. 9. Gallentine WB, Shinnar S, Hesdorffer DC, Epstein L, Nordli DR Jr, Lewis DV, et al. Plasma cytokines associated with febrile status epilepticus in children: A potential biomarker for acute hippocampal injury. Epilepsia. 2017;58(6):1102-1111. 10. Uludag IF, Duksal T, Tiftikcioglu BI, Zorlu Y, Ozkaya F, Kirkali G. IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy. Seizure, 2015;26:22–25
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Review |
| Authors | |
| Publication Date | June 8, 2020 |
| Published in Issue | Year 2020 Volume: 10 Issue: 2 |