Year 2021, Volume 11 , Issue 1, Pages 22 - 28 2021-03-15

KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease

Mehmet KIŞ [1] , Elton SOYDAN [2] , Tuba TATLI KIŞ [3] , Gülden HAKVERDİ [4]


ÖZET Amaç: Endotel fonksiyon bozukluğu koroner arter hastalığı gelişiminde ve prognozunda önemli rol oynar. Koroner arter hastalığında, uzun süreli ortalama glisemik indeksi gösteren bir parametre olan glikolize hemoglobinin (HbA1c) endotel fonksiyonları üzerine etkilerini değerlendirmeyi amaçladık. Gereç ve Yöntemler: Koroner anjiyografi ile belgelenmiş koroner arter hastalığı olan 56 hasta çalışmaya dahil edildi. Akım aracılı vazodilatasyon (AAD) testi ile endotel fonksiyonları değerlendirildi. İstatistiksel analiz için IBM SPSS Statistics 25.0 programı kullanıldı. Nümerik değişkenlerin normal dağılıma uygunluğu Kolmogorov-Smirnov (n≥50) testiyle incelendi. HbA1c ve AAD yüzdelik değişim arasındaki korelasyonu değerlendirmek için Spearman korelasyon analizi kullanıldı. Bulgular: Çalışmaya dahil edilen 56 hastanın ortalama yaşı 61,5±10,3 yıldır. Hastaların %71’ i erkek, %29’ u kadın ve ortalama vücut kitle indeksi 27,5±5,5 kg/m2’dir. AAD testinde ortalama radial arter bazal çapı 0,25 (±0,028) cm, AAD sonrası ortalama radial arter çapı 0,28 (±0,033) cm olarak saptandı. HbA1c düzeyleri ile endotel fonksiyonlarını gösteren arter çapındaki yüzdelik değişim arasında negatif yönde zayıf bir ilişki olduğu görüldü (r=-0,306, p=0,022). Sonuç: Koroner arter hastalığında, uzun süreli ortalama glisemik indeksi gösteren HbA1c düzeyleri endotel fonksiyon bozukluğunda bağımsız bir faktör olarak düşünülebilir. Anahtar Kelimeler: Koroner Arter Hastalığı; Endotel Fonksiyonu; Hba1c ABSTRACT Objective: Endothelial dysfunction plays an important role in the development and prognosis of coronary artery disease. We aimed to evaluate the effects of glycolyzed hemoglobin (HbA1c), which is a parameter that shows the long-term mean glycemic index, on endothelial functions in coronary artery disease. Material and Methods: Fifty-six patients who has coronary artery disease documented by coronary angiography were included in this study. Endothelial functions were evaluated by flow-mediated vasodilation (FMD) test. IBM SPSS Statistics 25.0 program was used for statistical analysis. The suitability of numerical variables to normal distribution was examined with Kolmogorov Smirnov (n≥50) test. Spearman correlation analysis was used to evaluate the correlation between HbA1c and FMD percent change. Results: The average age of 56 patients included in this study was 61.5 ± 10.3 years. 71% of the patients are male, 29% of patients are female and mean body mass index is 27.52 ± 5.54 kg / m2. In the FMD test, the mean radial artery basal diameter was 0.25 (±0.028) cm, and the mean radial artery diameter after FMD was 0.28 (± 0.033) cm. A negative correlation was observed between HbA1c levels and the percentage change in artery diameter that was showed endothelial functions (r = -0.306, p = 0.022). Conclusion: In coronary artery disease, HbA1c levels that showing long-term mean glycemic index can be considered as an independent factor in endothelial dysfunction. Keywords: Coronary Artery Disease; Endothelial Function; Hba1c
KORONER ARTER HASTALIĞINDA HbA1c DÜZEY, ENDOTEL FONKSİYONLAR, ARASINDAKİ İLİŞKİ
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Primary Language tr
Subjects Health Care Sciences and Services
Journal Section Original Research
Authors

Author: Mehmet KIŞ
Institution: SİNOP ATATÜRK DEVLET HASTANESİ
Country: Turkey


Author: Elton SOYDAN
Institution: EGE ÜNİVERSİTESİ
Country: Turkey


Author: Tuba TATLI KIŞ
Institution: ŞIRNAK SİLOPİ DEVLET HASTANESİ
Country: Turkey


Author: Gülden HAKVERDİ
Institution: EGE UNIVERSITY
Country: Turkey


Dates

Publication Date : March 15, 2021

Bibtex @research article { bozoktip893572, journal = {Bozok Tıp Dergisi}, issn = {2146-4006}, eissn = {2148-2438}, address = {}, publisher = {Bozok University}, year = {2021}, volume = {11}, pages = {22 - 28}, doi = {}, title = {KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease}, key = {cite}, author = {Kış, Mehmet and Soydan, Elton and Tatlı Kış, Tuba and Hakverdi, Gülden} }
APA Kış, M , Soydan, E , Tatlı Kış, T , Hakverdi, G . (2021). KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease . Bozok Tıp Dergisi , 11 (1) , 22-28 . Retrieved from https://dergipark.org.tr/en/pub/bozoktip/issue/60646/893572
MLA Kış, M , Soydan, E , Tatlı Kış, T , Hakverdi, G . "KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease" . Bozok Tıp Dergisi 11 (2021 ): 22-28 <https://dergipark.org.tr/en/pub/bozoktip/issue/60646/893572>
Chicago Kış, M , Soydan, E , Tatlı Kış, T , Hakverdi, G . "KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease". Bozok Tıp Dergisi 11 (2021 ): 22-28
RIS TY - JOUR T1 - KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease AU - Mehmet Kış , Elton Soydan , Tuba Tatlı Kış , Gülden Hakverdi Y1 - 2021 PY - 2021 N1 - DO - T2 - Bozok Tıp Dergisi JF - Journal JO - JOR SP - 22 EP - 28 VL - 11 IS - 1 SN - 2146-4006-2148-2438 M3 - UR - Y2 - 2021 ER -
EndNote %0 Bozok Tıp Dergisi KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease %A Mehmet Kış , Elton Soydan , Tuba Tatlı Kış , Gülden Hakverdi %T KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease %D 2021 %J Bozok Tıp Dergisi %P 2146-4006-2148-2438 %V 11 %N 1 %R %U
ISNAD Kış, Mehmet , Soydan, Elton , Tatlı Kış, Tuba , Hakverdi, Gülden . "KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease". Bozok Tıp Dergisi 11 / 1 (March 2021): 22-28 .
AMA Kış M , Soydan E , Tatlı Kış T , Hakverdi G . KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease. Bozok Tıp Dergisi. 2021; 11(1): 22-28.
Vancouver Kış M , Soydan E , Tatlı Kış T , Hakverdi G . KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease. Bozok Tıp Dergisi. 2021; 11(1): 22-28.
IEEE M. Kış , E. Soydan , T. Tatlı Kış and G. Hakverdi , "KORONER ARTER HASTALIĞINDA HbA1c DÜZEYİ İLE ENDOTEL FONKSİYONLARI ARASINDAKİ İLİŞKİ The Relationship Between HbA1c Level And Endothelial Functions In Coronary Artery Disease", Bozok Tıp Dergisi, vol. 11, no. 1, pp. 22-28, Mar. 2021