RELATIONSHIP BETWEEN MODIFIED SYSTEMIC IMMUNE-INFLAMMATION INDEX AND CONTRAST-INDUCED NEPHROPATHY IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION ST Segment Yükselmeli Miyokard İnfarktüsü Olan Hastalarda Modifiye Sistemik İmmün İnflamasyon İndeksi ile Kontrastın Neden Olduğu Nefropati Arasındaki İlişki

Year 2024, Volume: 14 Issue: 3, 152 - 159, 15.09.2024

Levent Özdemir , Adil Bayramoğlu

Abstract

ABSTRACT
Objective: Developing contrast induced nephropathy after primary PCI in patients with ST segment elevation
myocardial infarction is a risky condition in terms of mortality and morbidity. Various studies have shown
that the systemic inflammatory index predicts (SII) the development of CIN. Mean platelet volume (MPV)
is an important indicator known to be associated with the platelet function and activation. Therefore, we
revised SII and named it modified SII (mSII) by using NLR multiply MPV.
Material and Methods: This study includes patients who underwent pPCI due to STEMI in our cardiology
department between February 2015 and February 2021. Modified SII was obtained by using MPV instead
of platelet in the formula (mSII= NLR x MPV). Patients who underwent pPCI with STEMI were divided into
two groups, those with CIN and those without CIN, and compared. Informed consent was obtained from
all patients.
Results: In the logistic regression analysis, it was observed that the mSII, NLR, GFR and contrast medium
amount was independent predictor of CIN. The optimal threshold mSII for predicting CIN was >42.5, with a
78.1% sensitivity and 52.3% specificity ([AUC]: 0.639, 95%CI: 0.602- 0.674, p< 0.001). Pairwise comparison
of ROC curves, it was observed that the predictive value of mSII for the development of CIN was better than
NLR. (z-test = 3.144, P = 0.001)
Conclusion: We think that mSII, which we have shown to be superior to SII in predicting the development
of CIN and is very easy to calculate, is a parameter that can be considered in predicting the development of
CIN after pPCI in STEMI patients.

Keywords

RELATIONSHIP BETWEEN MODIFIED SYSTEMIC IMMUNE-INFLAMMATION INDEX AND, CONTRAST-INDUCED NEPHROPATHY IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION, ST Segment Yükselmeli Miyokard İnfarktüsü Olan Hastalarda Modifiye Sistemik İmmün İnflamasyon İndeksi ile Kontrastın Neden Olduğu Nefropati Arasındaki İlişki

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