Köpek Demodikozisinde Genel Tanı ve Tedavi Yöntemleri

Year 2020, Volume: 1 Issue: 1-2, 51 - 60, 15.12.2020

Güvenç Gökalp Akın Kırbaş

Abstract

Demodikozis olgusu özellikle immunsupresif ve sekonder hastalıklara maruz kalmış köpeklerde deri bağışıklık sisteminin zayıflaması sonucu demodeks akarlarının kıl folikülleri ve deri yüzeyinde çok fazla sayıda artması ile karakterizedir. Klinik tanı zor olmamakla birlikte veteriner hekimler tarafından enfestasyonun şiddetinin etkili teşhis yöntemleriyle belirlenmesi ve bu hastalığa uygun etkili tedavi yöntemlerinin kısa sürede uygulanması, hastalığın kontrol altına alınması açısından oldukça önemlidir. Tanıda invaziv olmayan yöntemlerin seçimi hem hasta köpeklere hem de hasta sahiplerine hastalığın tedavi süreci boyunca olumlu etkileri olacaktır. Süper yapıştırıcı baskı (SSI) yöntemi, uygulama esnasında hastaya çok az rahatsızlık veren renksiz ve yarı saydam yapıştırıcı özelliği ile foliküler bakının ve akar izolasyonunun kolay olduğu invaziv olmayan bir yöntemdir. Tedavi protokolleri açısından ise son zamanlarda genellikle ağız yoluyla yapılan akarisit kökenli tek doz uygulamalar yaygınlaşmıştır. Özellikle fluralaner etken maddeli preparatlar gibi tek doz uygulama ile kısa sürede etkin sonuç alınabilen güncel tedavi yöntemleri dikkati çekmektedir.

Keywords

Köpek, Demodikozis, SSI, Fluralaner, Tanı, Tedavi

References

• 1. Sharma P, Wadhwa DR, Katoch A, Sharma A. Epidemiological, clinico-haematological and therapeutic studies on canine demodicosis. Journal of Dairy, Veterinary & Animal Research 2018; 7: 109‒113.
• 2. Maravi P, Tiwari A, Shukla PC, Baghel RPS, Singh B, et al. Therapeutic management of chronic generalized demodicosis in dogs. Journal of Entomology and Zoology Studies 2018; 6: 1867-1869.
• 3. Gazi U, Ozkan AT, Mumcuoğlu KY. Immune mechanisms in human and canine demodicosis: A review. Parasite Immunology 2019; 41: e12673.
• 4. Manu M, Unnikrishnan K, Bora M. Efficacy of combination of orally administered ivermectin (Neomac) and topically applied amitraz (RIDD® solution) against generalized demodicosis in dog. The Pharma Innovation Journal 2019; 8: 38-41.
• 5. Nunez CM, Waisburd SG, Cordero AM, Gonzalez VB, Cardenas RH, et al. First report of the use of afoxolaner/milbemycin oxime in an african pygmy hedgehog (Atelerix Albiventris) with demodicosis caused by Demodex canis identified by molecular techniques. Journal of Exotic Pet Medicine 2019; 29:128-130.
• 6. Maden M, Er C, Kav K, Özdemir Ö. İngiliz pointer ırkı bir köpekte demodex canis kökenli atipik dermatitis olgusunun başarılı sağaltımı. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2012; 18: 1073-1077.
• 7. Scott DW. Canine demodicosis. Australian and New Zealand College of Veterinary Scientists Dermatology Chapter Science Week Proceedings 12-13, 2013; Australia.
• 8. Mueller RS, Rosenkrantz W, Bensignor E, Karas-Tecza J, Paterson T et al. Diagnosis and treatment of demodicosis in dogs and cats. Veterinery Dermatology 2020; 31: 4–e2.
• 9. Kumari P, Nigam R, Choudhury S, Singh SK, Yadav B, et al. Demodex canis targets TLRs to evade host immunity and induce canine demodicosis. Parasite Immunology 2018; 40: e12509.
• 10. Beugnet F, Halos L, Larsen D, De Vos C. Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis. Parasite 2016; 23: 1-8.
• 11. 11. Lacey N, Russell-Hallinan A, Powell FC. Study of demodex mites: challenges and solutions. The Journal of the European Academy of Dermatology and Venereology 2016; 30: 764–775.
• 12. Lam NSK, Long XX, Griffin R, Chen MK, Doery JCG. Can the tea tree oil (Australian native plant: Melaleuca alternifolia Cheel) be an alternative treatment for human demodicosis on skin? Parasitology 2018; 145:1510–1520.
• 13. Sousa VRF, Gasparetto ND, Almeida APF. Clinical and immuno-pathology aspects of canine demodicosis. Pacheco GAB, Kamboh AA.eds. In: Parasitology and Microbiology Research. Croatia: IntechOpen, 2020; pp. 1-13.
• 14. Vladimirovna MT. Two morphologically distinct forms of demodex mites found in dogs with canine demodicosis from vladivostok, Russia. Acta Veterinaria-Beograd 2017; 67: 82-91.
• 15. Zhao YE, Wang ZH, Xu Y, Xu JR, Liu WY, et al. Cloning and sequence analysis of chitin synthase gene fragments of Demodex mites. Journal of Zhejiang University science b (biomedicine & biotechnology) 2012; 13: 763-768.
• 16. Mueller R, Shipstone M. Update on the diagnosis and treatment of canine demodicosis. Advances in Veterinary Dermatology. Volume 8. Part 7. Proceedings of the Eighth World Congress of Veterinary Dermatology Bordeaux. France. 2016.
• 17. Sastre N, Francino O, Curti JN, Armenta TC, Fraser DL, et al. Detection, prevalence and phylogenetic relationships of Demodex spp and further skin prostigmata mites (acari, arachnida) in wild and domestic mammals. Public Library of Science One 2016; 11: 1-20.
• 18. O’Neill DG, Turgoose E, Churh DB, Brodbelt DC, Hendrics A. Juvenile-onset and adult-onset demodicosis in dogs in the UK: prevalence and breed associations. Journal of Small Animal Practice 2020; 61: 32–41.
• 19. Janczak D, Ruszczak A, Kaszak I, Golab E, Barszcz K. Clinical aspects of demodicosis in veterinary and human medicine. Medycyna weterynaryjna 2017; 73: 265-271.
• 20. Deepak D, Chaudhary K, Yadav S, Das AK, Patel PK, et al. Clinical investigation and therapeutic management of canine demodicosis with doramectin: a case study. Journal of Entomology and Zoology Studies 2018; 6: 1012-1015.
• 21. Zewe CM, Altet L, Lam ATH, Ferrer L. Afoxolaner and fluralaner treatment do not impact on cutaneous demodex populations of healthy dogs. Veterinary Dermatology 2017; 28: 468–e107.
• 22. Salem NY, Abdel-Saeed H, Farag HS, Ghandour RA. Canine demodicosis: hematological and biochemical alterations. Veterinary World 2020; 13: 68-72.
• 23. Sgarbossa RSAS, Sechi GV, Pacheco BD, Lucina SB, Paulo MR, et al. The epidemiological and clinical aspects of Demodex injai demodicosis in dogs: a report of eight cases. Semina: Ciencias Agrarias 2017; 38: 3387-3394.
• 24. Chávez F. Case Report of Afoxolaner Treatment for Canine Demodicosis in Four Dogs Naturally Infected with Demodex Canis. International Journal of Applied Research in Veterinary Medicine 2016; 14: 123-127.
• 25. Pekmezci D, Pekmezci GZ, Guzel M, Cenesiz S, Gurler AT, et al. Efficacy of amitraz plus inactivated parapoxvirus ovis in the treatment of canine generalised demodicosis. Veterinary Record 2014; 174: 556.
• 26. Mueller RS, Bensignor E, Ferrer L, Holm B, Lemarie S, et al. Treatment of demodicosis in dogs: 2011 clinical practice guidelines. Veterinary Dermatology 2012; 23: 86-e21.
• 27. Perego R, Spada E, Foppa C, Proverbio D. Critically appraised topic for the most effective and safe treatment for canine generalised demodicosis. BMC Veterinary Research 2019; 15: 1-7.
• 28. Immediato D. Suspected calcinosis cutis and demodicosis, secondary to an exogenous steroid administration in a dog with hypoadrenocorticism. Frontiers in Medical Case Reports 2020; 1: 1-11.
• 29. Kitaa JMA, Abuom TO, Gitonga P, Muraya J. Chronic pododemodicosis in a Great Dane. A Journal of The Kenya Veterinary Association 2012; 36: 1-4.
• 30. Udainiya S, Tiwari A, Singh B, Raikwar A, Sheikh AA, et al. Therapeutic management of complicated Demodicosis: A case report. The Pharma Innovation Journal 2018; 7: 751-752.
• 31. Kumar A, Kumar A, Sinha RK, Tiwary R, Kumari N. Clinical management of frustrating canine generalized demodecosis in a female germansephard dog: a case report. The Pharma Innovation Journal 2018; 7: 634-636.
• 32. Singh SK. Superglue slide impression (SSI) method: a novel diagnostic application for canine demodicosis. Experimental and Applied Acarology 2019; 79: 387–393.
• 33. Djuric M, Matic NM, Davitkov D, Glavinic U, Davitkov D, et al. Efficacy of oral fluralaner for the treatment of canine generalized demodicosis: a molecular-level confirmation. Parasites & Vectors 2019; 12: 270.
• 34. Suartha NI, Nainggolan WM, Sidjabat YR, Restiati NM. The Comparison of scraping, trichogram, and taping techniques for diagnosis of demodicosis in dog. Jurnal Veteriner Maret 2018; 19: 85-90.
• 35. 35. Ravera I, Altet L, Francino O, Bardagí M, Sánchez A, et al. Development of a real-time PCR to detect Demodex canis DNA in different tissue samples. Parasitology Research 2011; 108: 305–308.
• 36. 36. de Rojas M, Riazzo C, Callejón R, Guevara D, Cutillas C. Molecular study on three morphotypes of Demodex mites (acarina: demodicidae) from dogs. Parasitology Research 2012; 111: 2165-2172.
• 37. Sastre N, Ravera I, Villanueva S, Altet L, Bardagı M, et al. Phylogenetic relationships in three species of canine demodex mite based on partial sequences of mitochondrial 16S rDNA. Veterinary Dermatology 2012; 23: 509–e101.
• 38. Martinez-Subiela S, Bernal LJ, Tvarijonaviciute A, Garcia-Martinez JD, Tecles F, et al. Canine demodicosis: the relationship between response to treatment of generalised disease and markers for inflammation and oxidative status. Veterinary Dermatology 2014; 25: 72–e24.
• 39. 39. Kumar P, Shekhar S. Occurrence of dermatological disorders and haemato-biochemical alteration, treatment of demodicosis in dogs. Journal of Entomology and Zoology Studies 2020; 8: 126-132.
• 40. Hansson GK, Edfeldt K. Toll to be paid at the gateway to the vessel wall. Arteriosclerosis, Thrombosis, and Vascular Biology 2005; 25: 1085-1087.
• 41. Soman SP, Singh SK, Kumari P, Choudhury S, Singh A, et al. Quantification of immuno-regulatory cytokine and toll-like receptors gene expression in dogs with generalized demodicosis. Veterinary Parasitology 2020; 280: 109063.
• 42. Ravera I, Ferreira D, Gallego LS, Bardagí M, Ferrer L. Serum detection of IgG antibodies against Demodex canis by western blot in healthy dogs and dogs with juvenile generalized demodicosis. Research in Veterinary Science 2015; 101: 161–164.
• 43. Clanner-Engelshofen BM, French LE, Reinholz M. Methods for extraction and ex-vivo experimentation with the most complex human commensal, Demodex spp. Experimental and Applied Acarology 2020; 80: 59–70.
• 44. Barillas OF, Bajwa J, Guillot J, Arcique AJM. Comparison of acetate tape impression, deep skin scraping, and microscopic examination of hair for therapeutic monitoring of dogs with juvenile generalized demodicosis: a pilot study. Canadian Veterinary Journal 2019; 60: 596–600.
• 45. Pereira AV, Pereira SA, Gremião IDF, Campos MP, Ferreira AMR. Comparison of acetate tape impression with squeezing versus skin scraping for the diagnosis of canine demodicosis. Australian Veterinary Journal 2012; 90: 448–450.
• 46. Paterson TE, Halliwell RE, Fields PJ, Louw ML, Louw JP, et al. Treatment of canine-generalized demodicosis: a blind, randomized clinical trial comparing the efficacy of Advocate® (Bayer Animal Health) with ivermectin. Veterinary Dermatology 2009; 20: 447–455.
• 47. 47. Six RH, Becskei C, Mazaleski MM, Fourie JJ, Mahabir SP, et al. Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Veterinary Parasitology 2016; 222: 62–66.
• 48. Coşkun D. Veteriner Destek Tedavi: Tarantula cubensis alkolik ekstraktı, inaktif Parapoxvirüs ovis ve Corynebacterium cutis lizatı. Dicle Üniversitesi Veteriner Fakültesi Dergisi 2017; 10: 30-37.
• 49. Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: a non-inferiority study. Veterinary Dermatology 2018; 29: 203–e72.
• 50. Fourie JJ, Meyer L, Thomas E. Efficacy of topically administered fluralaner or imidacloprid/moxidectin on dogs with generalised demodicosis. Parasites & Vectors 2019; 12: 1-5.
• 51. Fourie JJ, Liebenberg JE, Horak IG, Taenzler J, Heckeroth AR, et al. Efficacy of orally administered fluralaner (BravectoTM) or topically applied imidacloprid/ moxidectin (Advocate®) against generalized demodicosis in dogs. Parasites & Vectors 2015; 8: 1-7.
• 52. Petersen I, Chiummo R, Zschiesche E, Karas Tecza J, Rapti D, et al. European field assessment of the efficacy of fluralaner (Bravecto®) chewable and spot-on formulations for treatment of dogs with generalized demodicosis. Parasites & Vectors 2020; 13: 1-7.
• 53. Halos L, Lebon W, Chalvet-Monfray K, Larsen D, Beugnet F. Immediate efficacy and persistent speed of kill of a novel oral formulation of afoxolaner (NexGardTM) against induced infestations with Ixodes ricinus ticks. Parasites & Vectors 2014; 7: 1-4.
• 54. Beugnet F, Liebenberg J, Halos L. Comparative efficacy of two oral treatments for dogs containing either afoxolaner or fluralaner against Rhipicephalus sanguineus sensu lato and Dermacentor reticulatus. Veterinary Parasitology 2015; 209: 142–145.
• 55. 55. Lebon W, Beccatti M, Bourdeau P, Brement T, Bruet V, et al. Efficacy of two formulations of afoxolaner (NexGard® and NexGard Spectra®) for the treatment of generalised demodicosis in dogs, in veterinary dermatology referral centers in Europe. Parasites &Vectors 2018; 11:506.
• 56. Ferrer L, Ravera I, Silbermayr K. Immunology and pathogenesis of canine demodicosis. Veterinary Dermatology 2014; 25: 427–e65.
• 57. Forton FMN. Papulopustular rosacea, skin immunity and demodex: pityriasis folliculorum as a missing link. Journal of the European Academy of Dermatology and Venereology 2012; 26: 19-28.
• 58. Akilov OE, Mumcuoglu KY. Immune response in demodicosis. Journal of the European Academy of Dermatology and Venereology 2004; 18: 440–444.
• 59. Reddy BS, Kumari KN, Sivajothi S. Haemato-biochemical findings and thyroxin levels in canine demodicosis. Comparative Clinical Pathology 2015; 24: 287-290.