Leukemia in Dogs

Year 2022, Volume: 3 Issue: 1, 20 - 27, 30.06.2022

Emre Tüfekçi , Gencay Ekinci , İhsan Keleş

Abstract

This review has been prepared considering the increase in the number of dogs diagnosed with leukemia brought to the Erciyes University Faculty of Veterinary Medicine Training, Research and Practice Hospital Internal Diseases Clinic. Considering that dog breeds such as German shepherds and Golden Retrievers, where the disease is common, are becoming increasingly widespread in our country, so, the problem might continue in increasing manner in the near future in our country. Based on the lack of consensus on the diagnosis and treatment protocol of this disease in veterinary medicine, information about the types, etiology, pathophysiology, clinical signs, diagnosis, treatment and possible prognosis of the disease is given in this review. The aim of this review is to improve the quality of life and prolong the life span of dogs with leukemia with correct diagnosis and appropriate treatment protocols. We believe that this review, prepared in the light of existing literature, will be useful for veterinarians.

Keywords

Acute lymphoblastic leukemia, Acute myeloid leukemia, Chronic lymphocytic leukemia, Dog

Köpeklerde Lösemi

Abstract

Bu derleme Erciyes Üniversitesi Veteriner Fakültesi Eğitim, Araştırma ve Uygulama Hastanesi İç Hastalıkları Kliniği’ne getirilip, lösemi teşhisi konulan köpek sayısındaki artış göz önünde bulundurularak hazırlanmıştır. Hastalığın yaygın olarak görüldüğü Alman çoban köpekleri ve Golden Retriever gibi köpek ırklarının ülkemizde giderek yaygınlaştığı da dikkate alınarak, sorunun ülkemizde yakın gelecekte de artarak devam edeceği düşünülmektedir. Veteriner hekimliğinde bu hastalığın teşhis ve tedavi protokolünde fikir birliğinin olmayışından yola çıkılarak, bu derlemede hastalığın türleri, etiyolojisi, patofizyolojisi, klinik bulguları, teşhisi, tedavisi ve muhtemel prognozu hakkında bilgiler verilmiştir. Derlemenin amacı, lösemili köpeklerde, doğru teşhis ve uygun tedavi protokolleri ile yaşam kalitesini artırma ve yaşam sürelerini uzatmaktır. Mevcut literatür bilgisi ışığında hazırlanan bu derlemenin veteriner hekimler için yararlı olacağı kanaatini taşımaktayız.

Keywords

Akut lenfoblastik lösemi, Akut miyeloid lösemi, Köpek, Kronik lenfositik lösemi

References

• 1. Avery AC. The genetic and molecular basis for canine models of human leukemia and lymphoma. Front Oncol 2020; 10: 23. doi: 10.3389/fonc.2020.00023.
• 2. Boes KM, Raskin RE. Hematolojik Hastalıklar, çev. Ağaoğlu ZT, Başbuğ O, Köpek ve Kedilerin Klinik Hekimliği, haz. Altuğ N. 3. Baskı. Ankara: Güneş Tıp Kitabevleri, 2019; s.734-744.
• 3. American Dental Association (ADA). The ADA Practical Guide to Patients with Medical Conditions. New York, NY: Wiley, 2012; 143-173.
• 4. Bodzas A, Kodytek P, Zidek J. Automated detection of acute lymphoblastic leukemia from microscopic images based on human visual perception. Front Bioeng Biotechnol 2020; 8: 1005. doi: 10.3389/fbioe.2020.01005.
• 5. Özkalemkaş F. Nedir bu hematopoetik kök hücre? XXX. Ulusal Hematoloji Kongresi, III. Hematoloji İlk Basamak Kursu. Ekim, 10-14, 2013; İstanbul-Türkiye.
• 6. Daniels R, Nicoll LH. Contemporary Medical Surgical Nursing, 2nd Edt. New York, NY: Cengage Learning, 2012.
• 7. Serfontein W. Cancer Diagnosed: What Now? Second Edition. Bloomington: Xlibris, 2011; 198.
• 8. Vilalba IL, Sanchez IM. Küçük Hayvanlarda Laboratuvar Testlerinin Yorumlanması ve Ayırıcı Tanı İçin Pratik Rehber, Hematoloji ve Biyokimya, çev. Keleş İ, Çitil M, Güneş V. 1. Baskı. Kayseri: Verda Yayıncılık, 2020; s.38-39.
• 9. Presley RH, Mackin A, Vernau W. Lymphoid leukemia in dogs. Compendium 2006; 28 (12): 831-849.
• 10. Vernau W, Moore PF. An immunophenotypic study of canine leukemias and preliminary assessment of clonality by polymerase Chain reaction. Vet Immunol Immunopathol 1999; 69: 145-164.
• 11. Moore PF, Vernau W: Immunophen otyping in the dog, in Bonagura J (ed): Kirk's Current Veterinary Therapy. Philadelphia, WB Saunders, 2000, pp.505-509.
• 12. Workman HC, Vernau W. Chronic lymphocytic leukemia in dogs and cats: the veterinary perspective. Vet Clin Small Anim 2003; 33 (6): 1379-1399.
• 13. Couto CG. Leukemias. Small Animal Internal Medicine. St. Louis, Mosby, 2003, pp.1134-1138.
• 14. Stokol T, Schaefer DM, Shuman M, Belcher N, Dong L. Alkaline phosphatase is a useful cytochemical marker for the diagnosis of acute myelomonocytic and monocytic leukemia in the dog. Vet Clin Pathol 2015; 44 (1): 79-93.
• 15. Davis LL, Hume KR, Stokol T. A retrospective review of acute myeloid leukaemia in 35 dogs diagnosed by a combination of morphologic findings, flow cytometric immunophenotyping and cytochemical staining results (2007‐2015). Vet Comp Oncol 2018; 16 (2): 268-275.
• 16. Schneider R. Comparison of age-and sex-specific incidence rate patterns of the leukemia complex in the cat and the dog. JNCI 1983; 70 (5): 971-977.
• 17. Wartenberg D, Groves FD, Adelman AS. Acute lymphoblastic leukemia: epidemiology and etiology. In Acute leukemias . Springer, Berlin, Heidelberg, 2008; pp.77-93.
• 18. Leifer CE, Matus RE. Lymphoid leukemia in the dog: Acute lymphoblastic leukemia and chronic lymphocytic leukemia. Vet Clin North Am Small Anim 1985; 15 (4): 723-739.
• 19. Dobson J, Villiers E, Morris J. Diagnosis and management of leukaemia in dogs and cats. In Pract 2006; 28 (1): 22-31.
• 20. Morris J, Dobson J. Haematopoeitic system. In: Small Animal Oncology, First edition. Oxford, Blackwell Science Ltd 2001; pp. 239-245.
• 21. Adam F, Villiers E, Watson S, Coyne K, Blackwood L. Clinical pathological and epidemiological assessment of morphologically and immunologically confirmed canine leukaemia. Vet Comp Oncol 2009; 7 (3): 181-195.
• 22. Tasca S, Carli E, Caldin M, Menegazzo L, Furlanello T, Gallego LS. Hematologic abnormalities and flow cytometric immunophenotyping results in dogs with hematopoietic neoplasia: 210 cases (2002–2006). Vet Clin Pathol 2009; 38 (1): 2-12.
• 23. Kozicki AR. Lymphoid Leukemias, Myeloid Neoplasia, and Myelodysplastic Syndrome. Bruyette D. eds. In: Clinical Small Animal Internal Medicine. First edition. USA: Wiley-Blackwell, 2020; pp.1223-1230.
• 24. Matus RE, Leifer CE, MacEwen EG. Acute lymphoblastic leukemia in the dog: A review of 30 cases. JAVMA 1983; 183 (8): 859-862.
• 25. Bennett AL, Williams LE, Ferguson MW, Hauck ML, Suter SE, Lanier CB, Hess PR. Canine acute leukaemia: 50 cases (1989–2014). Vet Comp Oncol 2017; 15 (3): 1101-1114.
• 26. Mori T, Kadosawa T. Acute respiratory failure caused by leukemic infiltration of the lung of a dog. J Small Anim Pract 2001; 42 (7): 349-351.
• 27. Henrich M. Hematopoietic Tumors. Klopfleisch R. edt. In: Veterinary Oncology, A Short Textbook. Switzerland: Springer International Publishing, 2016; pp.110-116.
• 28. McDonough SP, Moore PF. Clinical, hematologic, and immunophenotypic characterization of canine large granular lymphocytosis. Vet Pathol 2000; 37 (6): 637-646.
• 29. The Leukemia and Lymphoma Society. Acute lymphocytic leukemia. The Leukemia and Lymphoma Society, White Plains, NY, 2005.
• 30. Novacco M, Comazzi S, Marconato L, Cozzi M, Stefanello D, Aresu L, Martini V. Prognostic factors in canine acute leukaemias: a retrospective study. Vet Comp Oncol 2016; 14 (4): 409-416.