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Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions

Year 2025, Volume: 8 Issue: 3, 885 - 890, 15.05.2025
https://doi.org/10.34248/bsengineering.1617721

Abstract

This study focused on the conversion of glucose into high-value chemicals, specifically furfural (FFR) and 5-hydroxymethylfurfural (HMF), through hydrothermal reaction processes. Glucose was decomposed under subcritical water conditions (160-220 °C) in a Teflon-lined stainless-steel reactor, and the evolution of FFR and HMF products was examined over residence times ranging from 30 to 210 minutes. The highest yields of FFR and HMF were achieved at a temperature of 220 °C and a residence time of 180 minute. Increasing the temperature from 160°C to 220°C and extending the residence time from 30 to 180 minutes enhanced the hydrolysis of glucose. The yields of FFR and HMF were determined using high performance liquid chromatography (HPLC).

Ethical Statement

Ethics committee approval was not required for this study because of there was no study on animals or humans.

References

  • Agirrezabal-Telleria I, Gandarias I, Arias PL. 2014. Heterogeneous acid-catalysts for the production of furan derived compounds (furfural and hydroxymethyl furfural) from renewable carbohydrates: A review. Catal Today, 234: 42-58.
  • Ahmad FB, Kalam MA, Zhang Z, Masjuki HH. 2022. Sustainable production of furan-based oxygenated fuel additives from pentose-rich biomass residues. Energ Convers Man-x, 14: 100222.
  • Aida TM, Sato Y, Watanabe M, Tajima K, Nonaka T, Hattori H, Arai K. 2007. Dehydration of d-glucose in high temperature water at pressures up to 80 MPa. J Supercrit Fluids, 40(3): 381-388.
  • Ariffin AA, Ghazali HM, Kavousi P. 2014. Validation of a HPLC method for determination of hydroxymethylfurfural in crude palm oil. Food Chem, 154: 102-107.
  • Bobleter O. 1994. Hydrothermal degradation of polymers derived from plants. Prog Polym Sci, 19(5): 797-841.
  • Bohre A, Dutta S, Saha B, Abu-Omar MM. 2015. Upgrading furfurals to drop-in biofuels: An overview. ACS Sustain Chem Eng, 3(7): 1263-1277.
  • Bridgwater AV. 2003. Renewable fuels and chemicals by thermal processing of biomass. Chem Eng J, 91(2-3): 87-102.
  • Cantero D, Álvarez A, Bermejo MD, Cocero MJ. 2015. Transformation of glucose into added value compounds in a hydrothermal reaction media. J Supercrit Fluids, 98: 204-210.
  • Corma A, Iborra S, Velty A. 2007. Chemical routes for the transformation of biomass into chemicals. Chem Rev, 107(6): 2411-2502.
  • Dashtban M, Gilbert A, Fatehi P. 2012. Production of furfural: overview and challenges. J Sci Technol For Prod Process, 2(4): 44-53.
  • Driffield M, Chan D, Macarthur R, MacDonald S, Brereton P, Wood R. 2005. Single laboratory validation of a method for the determination of hydroxymethylfurfural in honey by using solid-phase extraction cleanup and liquid chromatography. J AOAC Int, 88(1): 121-127.
  • Girisuta B, Janssen LPBM, Heeres HJ. 2006. A kinetic study on the decomposition of 5-hydroxymethylfurfural into levulinic acid. Green Chem, 8(8): 701-709.
  • He O, Zhang Y, Wang P, Liu L, Wang Q, Yang N, Yu H. 2020. Experimental and kinetic study on the production of furfural and HMF from glucose. Catalysts, 11(1): 11.
  • Jaswal A, Singh PP, Mondal T. 2022. Furfural–a versatile, biomass-derived platform chemical for the production of renewable chemicals. Green Chem, 24(2): 510-551.
  • Jin F, Enomoto H. 2011. Rapid and highly selective conversion of biomass into value-added products in hydrothermal conditions: chemistry of acid/base-catalysed and oxidation reactions. Energy Environ Sci, 4(2): 382-397.
  • Knezevic D, van Swaaij WPM, Kersten SR. 2009. Hydrothermal conversion of biomass: I, glucose conversion in hot compressed water. Ind Eng Chem Res, 48(10): 4731-4743.
  • Kucherov FA, Romashov LV, Galkin KI, Ananikov VP. 2018. Chemical transformations of biomass-derived C6-furanic platform chemicals for sustainable energy research, materials science, and synthetic building blocks. ACS Sustain Chem Eng, 6(7): 8064-8092.
  • Lee R, Harris J, Champagne P, Jessop PG. 2016. CO2-catalysed conversion of carbohydrates to 5-hydroxymethyl furfural. Green Chem, 18(23): 6305-6310.
  • Mariscal R, Maireles-Torres P, Ojeda M, Sádaba I, Granados ML. 2016. Furfural: a renewable and versatile platform molecule for the synthesis of chemicals and fuels. Energy Environ Sci, 9(4): 1144-1189.
  • Ragauskas AJ, Williams CK, Davison BH, Britovsek G, Cairney J, Eckert CA, Tschaplinski T, 2006. The path forward for biofuels and biomaterials. Science, 311(5760): 484-489.
  • Sajid M, Zhao X, Liu D. 2018. Production of 2,5-furandicarboxylic acid (FDCA) from 5-hydroxymethylfurfural (HMF): recent progress focusing on the chemical-catalytic routes. Green Chem, 20(24): 5427-5453.
  • Thunyaratchatanon C, Sinsakullert W, Luengnaruemitchai A, Faungnawakij K. 2021. 5-Hydroxymethylfurfural production from hexose sugars using adjustable acid-and base-functionalized mesoporous SBA-15 catalysts in aqueous media. Biomass Convers Biorefin, 11: 1733-1747.
  • van Putten RJ, Van Der Waal JC, De Jong ED, Rasrendra CB, Heeres HJ, de Vries JG. 2013. Hydroxymethylfurfural, a versatile platform chemical made from renewable resources. Chem Rev, 113(3): 1499-1597.
  • Wang T, Nolte MW, Shanks BH. 2014. Catalytic dehydration of C6 carbohydrates for the production of hydroxymethyl furfural (HMF) as a versatile platform chemical. Green Chem, 16(2): 548-572.
  • Zhang J, Li DN, Yuan HR, Wang SR, Chen Y. 2021. Advances on the catalytic hydrogenation of biomass-derived furfural and 5-hydroxymethylfurfural. J Fuel Chem Technol, 49(12): 1752-1766.
  • Zhao Y, Lu K, Xu H, Zhu L, Wang S. 2021. A critical review of recent advances in the production of furfural and 5-hydroxymethylfurfural from lignocellulosic biomass through homogeneous catalytic hydrothermal conversion. Renew Sustain Energy Rev, 139: 110706.

Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions

Year 2025, Volume: 8 Issue: 3, 885 - 890, 15.05.2025
https://doi.org/10.34248/bsengineering.1617721

Abstract

This study focused on the conversion of glucose into high-value chemicals, specifically furfural (FFR) and 5-hydroxymethylfurfural (HMF), through hydrothermal reaction processes. Glucose was decomposed under subcritical water conditions (160-220 °C) in a Teflon-lined stainless-steel reactor, and the evolution of FFR and HMF products was examined over residence times ranging from 30 to 210 minutes. The highest yields of FFR and HMF were achieved at a temperature of 220 °C and a residence time of 180 minute. Increasing the temperature from 160°C to 220°C and extending the residence time from 30 to 180 minutes enhanced the hydrolysis of glucose. The yields of FFR and HMF were determined using high performance liquid chromatography (HPLC).

Ethical Statement

Ethics committee approval was not required for this study because of there was no study on animals or humans.

References

  • Agirrezabal-Telleria I, Gandarias I, Arias PL. 2014. Heterogeneous acid-catalysts for the production of furan derived compounds (furfural and hydroxymethyl furfural) from renewable carbohydrates: A review. Catal Today, 234: 42-58.
  • Ahmad FB, Kalam MA, Zhang Z, Masjuki HH. 2022. Sustainable production of furan-based oxygenated fuel additives from pentose-rich biomass residues. Energ Convers Man-x, 14: 100222.
  • Aida TM, Sato Y, Watanabe M, Tajima K, Nonaka T, Hattori H, Arai K. 2007. Dehydration of d-glucose in high temperature water at pressures up to 80 MPa. J Supercrit Fluids, 40(3): 381-388.
  • Ariffin AA, Ghazali HM, Kavousi P. 2014. Validation of a HPLC method for determination of hydroxymethylfurfural in crude palm oil. Food Chem, 154: 102-107.
  • Bobleter O. 1994. Hydrothermal degradation of polymers derived from plants. Prog Polym Sci, 19(5): 797-841.
  • Bohre A, Dutta S, Saha B, Abu-Omar MM. 2015. Upgrading furfurals to drop-in biofuels: An overview. ACS Sustain Chem Eng, 3(7): 1263-1277.
  • Bridgwater AV. 2003. Renewable fuels and chemicals by thermal processing of biomass. Chem Eng J, 91(2-3): 87-102.
  • Cantero D, Álvarez A, Bermejo MD, Cocero MJ. 2015. Transformation of glucose into added value compounds in a hydrothermal reaction media. J Supercrit Fluids, 98: 204-210.
  • Corma A, Iborra S, Velty A. 2007. Chemical routes for the transformation of biomass into chemicals. Chem Rev, 107(6): 2411-2502.
  • Dashtban M, Gilbert A, Fatehi P. 2012. Production of furfural: overview and challenges. J Sci Technol For Prod Process, 2(4): 44-53.
  • Driffield M, Chan D, Macarthur R, MacDonald S, Brereton P, Wood R. 2005. Single laboratory validation of a method for the determination of hydroxymethylfurfural in honey by using solid-phase extraction cleanup and liquid chromatography. J AOAC Int, 88(1): 121-127.
  • Girisuta B, Janssen LPBM, Heeres HJ. 2006. A kinetic study on the decomposition of 5-hydroxymethylfurfural into levulinic acid. Green Chem, 8(8): 701-709.
  • He O, Zhang Y, Wang P, Liu L, Wang Q, Yang N, Yu H. 2020. Experimental and kinetic study on the production of furfural and HMF from glucose. Catalysts, 11(1): 11.
  • Jaswal A, Singh PP, Mondal T. 2022. Furfural–a versatile, biomass-derived platform chemical for the production of renewable chemicals. Green Chem, 24(2): 510-551.
  • Jin F, Enomoto H. 2011. Rapid and highly selective conversion of biomass into value-added products in hydrothermal conditions: chemistry of acid/base-catalysed and oxidation reactions. Energy Environ Sci, 4(2): 382-397.
  • Knezevic D, van Swaaij WPM, Kersten SR. 2009. Hydrothermal conversion of biomass: I, glucose conversion in hot compressed water. Ind Eng Chem Res, 48(10): 4731-4743.
  • Kucherov FA, Romashov LV, Galkin KI, Ananikov VP. 2018. Chemical transformations of biomass-derived C6-furanic platform chemicals for sustainable energy research, materials science, and synthetic building blocks. ACS Sustain Chem Eng, 6(7): 8064-8092.
  • Lee R, Harris J, Champagne P, Jessop PG. 2016. CO2-catalysed conversion of carbohydrates to 5-hydroxymethyl furfural. Green Chem, 18(23): 6305-6310.
  • Mariscal R, Maireles-Torres P, Ojeda M, Sádaba I, Granados ML. 2016. Furfural: a renewable and versatile platform molecule for the synthesis of chemicals and fuels. Energy Environ Sci, 9(4): 1144-1189.
  • Ragauskas AJ, Williams CK, Davison BH, Britovsek G, Cairney J, Eckert CA, Tschaplinski T, 2006. The path forward for biofuels and biomaterials. Science, 311(5760): 484-489.
  • Sajid M, Zhao X, Liu D. 2018. Production of 2,5-furandicarboxylic acid (FDCA) from 5-hydroxymethylfurfural (HMF): recent progress focusing on the chemical-catalytic routes. Green Chem, 20(24): 5427-5453.
  • Thunyaratchatanon C, Sinsakullert W, Luengnaruemitchai A, Faungnawakij K. 2021. 5-Hydroxymethylfurfural production from hexose sugars using adjustable acid-and base-functionalized mesoporous SBA-15 catalysts in aqueous media. Biomass Convers Biorefin, 11: 1733-1747.
  • van Putten RJ, Van Der Waal JC, De Jong ED, Rasrendra CB, Heeres HJ, de Vries JG. 2013. Hydroxymethylfurfural, a versatile platform chemical made from renewable resources. Chem Rev, 113(3): 1499-1597.
  • Wang T, Nolte MW, Shanks BH. 2014. Catalytic dehydration of C6 carbohydrates for the production of hydroxymethyl furfural (HMF) as a versatile platform chemical. Green Chem, 16(2): 548-572.
  • Zhang J, Li DN, Yuan HR, Wang SR, Chen Y. 2021. Advances on the catalytic hydrogenation of biomass-derived furfural and 5-hydroxymethylfurfural. J Fuel Chem Technol, 49(12): 1752-1766.
  • Zhao Y, Lu K, Xu H, Zhu L, Wang S. 2021. A critical review of recent advances in the production of furfural and 5-hydroxymethylfurfural from lignocellulosic biomass through homogeneous catalytic hydrothermal conversion. Renew Sustain Energy Rev, 139: 110706.
There are 26 citations in total.

Details

Primary Language English
Subjects Organic Green Chemistry, Biomass Energy Systems
Journal Section Research Articles
Authors

Koray Alper 0000-0001-6845-2087

Publication Date May 15, 2025
Submission Date January 11, 2025
Acceptance Date April 25, 2025
Published in Issue Year 2025 Volume: 8 Issue: 3

Cite

APA Alper, K. (2025). Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions. Black Sea Journal of Engineering and Science, 8(3), 885-890. https://doi.org/10.34248/bsengineering.1617721
AMA Alper K. Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions. BSJ Eng. Sci. May 2025;8(3):885-890. doi:10.34248/bsengineering.1617721
Chicago Alper, Koray. “Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions”. Black Sea Journal of Engineering and Science 8, no. 3 (May 2025): 885-90. https://doi.org/10.34248/bsengineering.1617721.
EndNote Alper K (May 1, 2025) Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions. Black Sea Journal of Engineering and Science 8 3 885–890.
IEEE K. Alper, “Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions”, BSJ Eng. Sci., vol. 8, no. 3, pp. 885–890, 2025, doi: 10.34248/bsengineering.1617721.
ISNAD Alper, Koray. “Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions”. Black Sea Journal of Engineering and Science 8/3 (May 2025), 885-890. https://doi.org/10.34248/bsengineering.1617721.
JAMA Alper K. Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions. BSJ Eng. Sci. 2025;8:885–890.
MLA Alper, Koray. “Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions”. Black Sea Journal of Engineering and Science, vol. 8, no. 3, 2025, pp. 885-90, doi:10.34248/bsengineering.1617721.
Vancouver Alper K. Transformation of Glucose into HMF and Furfural in Hydrothermal Reaction Conditions. BSJ Eng. Sci. 2025;8(3):885-90.

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