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            <front>

                <journal-meta>
                                    <journal-id></journal-id>
            <journal-title-group>
                                                                                    <journal-title>Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2458-7575</issn>
                                                                                            <publisher>
                    <publisher-name>Bilecik Seyh Edebali University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.35193/bseufbd.1499645</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Agricultural Engineering (Other)</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Ziraat Mühendisliği (Diğer)</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <article-title>Altınotu (Helichrysum italicum Mill.): Yetiştiriciliği ve Kullanım Alanları</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="en">
                                    <trans-title>Immortelle (Helichrysum italicum Mill.): Cultivation and Usage Areas</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-8606-0626</contrib-id>
                                                                <name>
                                    <surname>Taşgın</surname>
                                    <given-names>Selim</given-names>
                                </name>
                                                                    <aff>Geçit Kuşağı Tarımsal Araştırma Enstitüsü</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-8663-093X</contrib-id>
                                                                <name>
                                    <surname>Aytaç</surname>
                                    <given-names>Zehra</given-names>
                                </name>
                                                                    <aff>ESKİŞEHİR OSMANGAZİ ÜNİVERSİTESİ, ZİRAAT FAKÜLTESİ</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20250530">
                    <day>05</day>
                    <month>30</month>
                    <year>2025</year>
                </pub-date>
                                        <volume>12</volume>
                                        <issue>1</issue>
                                        <fpage>367</fpage>
                                        <lpage>375</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20240611">
                        <day>06</day>
                        <month>11</month>
                        <year>2024</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20241006">
                        <day>10</day>
                        <month>06</month>
                        <year>2024</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2014, Bilecik Seyh Edebali University Journal of Science</copyright-statement>
                    <copyright-year>2014</copyright-year>
                    <copyright-holder>Bilecik Seyh Edebali University Journal of Science</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>Altınotu bitkisi Asteraceae familyasının Helichrysum cinsine ait yarı çalımsı çok yıllık bir bitkidir. Helichrysum italicum Mill. Türkiye florasında olmamasına rağmen tipik bir Akdeniz bitkisidir. Dünya’da Hırvatistan, Bosna-Hersek, Arnavutluk ve Fransa’da yetiştiriciliği yapılmakla birlikte Türkiye’nin değişik illerinde de yetiştiriciliği yapılmaktadır. H. italicum kuru, kumlu ve kayalık bölgelerde doğal olarak yetişmektedir. Bitki yüksek yaz sıcaklıklarına ve kuraklığa dayanıklıdır. H. italicum hem generatif hemde vejetatif olarak çoğaltılabilmektedir. Ancak tohumları çok küçük olduğu için tohumların viyol ya da kasalara ekilmesi önerilmektedir. Vejetatif olarak ise 1 yıllık sürgünlerden alınan çelikler kullanılmaktadır. Fideler dikildikleri yıl verimleri genellikle düşük olmaktadır. En yüksek verim 3-6. yıllar arasında alınmaktadır. Ortalama taze herba verimi 700-800 kg/da, uçucu yağ verimi ise 0,8-1,2 kg/da arasında değişmektedir. Uçucu yağın önemli bileşenleri nerol, neril asetat, rosifiliol, selinen ve kurkumin türevleridir. Helichrysum cinsleri tarih boyunca geleneksel halk hekimliğinde kullanılmıştır. Genellikle diüretik ve safra düzenleyici olarak kullanılmaktadır. Bunun yanında antimikrobiyal, antibakteriyal, antiviral, antifungal, antioksidan ve antiinflamatuar etkileri olduğu da bilinmektedir. H.italicum bitkisinin uçucu yağları kozmetik sektöründe ve parfümeri sanayinde de kullanılmaktadır. Güney Asya ve Orta Doğu’da et yemeklerinde, taze peynirlerde ve salatalarda köri aroması olarak kullanılmaktadır.</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="en">
                            <p>The immortelle plant is a semi-shrub perennial plant belonging to the Helichrysum genus of the Asteraceae family. Although Helichrysum italicum Mill. is not found in the flora of Türkiye, it is a typical Mediterranean plant. Moreover, it is grown in Croatia, Bosnia-Herzegovina, Albania, France, and different regions of Türkiye. H. italicum grows naturally in dry, sandy, and rocky areas. The plant is resistant to high summer temperatures and drought. H. italicum can be propagated both generatively and vegetatively. However, since the seeds are very small, it is recommended to plant them in seedlings trays or boxes. For vegetative propagation, cuttings taken from one-year-old shoots are used. The yield of seedlings is usually low in the first year they are planted. The highest yield is obtained between the 3rd and 6th years. The average fresh herb yield ranges between 700-800 kg per decare, and the essential oil yield varies between 0.8-1.2 kg per decare. Major constituents of the essential oil include nerol, neryl acetatet, rosifoliol, selinene, and derivatives of curcumen. Species of the Helichrysum genus have been historically utilized in traditional folk medicine. They are predominantly employed as diuretic and choleretic agents. Additionally, they have been reported to possess antimicrobial, antibacterial, antiviral, antifungal, antioxidant, and anti-inflammatory properties. The essential oils of H. italicum are also widely used in the cosmetics and perfumery industries. Furthermore, in South Asia and the Middle East, they are employed as a curry-like flavoring in meat dishes, fresh cheeses, and salads.</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>Helichrysum italicum</kwd>
                                                    <kwd>  uçucu yağ</kwd>
                                                    <kwd>  üretim</kwd>
                                                    <kwd>  verim</kwd>
                                                    <kwd>  kullanım alanları</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="en">
                                                    <kwd>Helichrysum italicum</kwd>
                                                    <kwd>  essential oils</kwd>
                                                    <kwd>  production</kwd>
                                                    <kwd>  yield</kwd>
                                                    <kwd>  usage areas</kwd>
                                            </kwd-group>
                                                                                                            </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Davis, P.H., (Ed.) (1975). “Flora of Turkey and the East Aegean Islands” University Press, Edinburg, Vol.5, s:80-97.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Davis, P.H., Mill R.R., Tan K., (Ed) (1988). “Flora of Turkey and the East Aegean Islands-Supplement” University Press, Edinburg, Vol.10, s:159-160,342.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Öztürk, B. (2004). Türkiye Helichrysum’larının Flavonoid ve Uçucu yağ İçerikleri Açısından Karşılaştırması ve Antioksidan, Antimikrobial Aktivite Potansiyelleri. T.C. Ege Üniversitesi Sağlık Bilimleri Enstitüsü Farmasötik Botanik Anabilim Dalı Programı Doktora Tezi.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Coşkun, M. T. (2019). Helichrysum Compactum Boiss.(Asteraceae) Üzeri̇nde Morfoloji̇k, Mi̇kromorfoloji̇k ve Pali̇noloji̇k Çalışmalar (Master&#039;s Thesis, Pamukkale Üniversitesi Fen Bilimleri Enstitüsü).</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Appendino, G., Minassi, A., Pollastro, F., Taglialatela-Scafati, O., Ballero, M., Maxia, A., &amp; Sanna, C. (2015). Helichrysum italicum: the sleeping giant of Mediterranean herbal medicine. Herbalgram, (105).</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">Ličina, A., &amp; Kralj, V. R. (2016). Mediterranean Gold—Helichrysum italicum. Corsican Helichrysum, 5.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Albayrak, S., (2008). Türkiye Helichrysum Mill.(Asteraceae) Taksonlarının Biyoaktiviteleri. T.C. Erciyes Üniversitesi Fen Bilimleri Enstitüsü, Biyoloji Anabilim Dalı Doktora Tezi. Kayseri.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Ok, D. (2009). Türkiye Helichrysum Mıll. (Asteraceae) Taksonlarının Polen Morfolojileri. T.C Erciyes Üniversitesi Fen Bilimleri Enstitüsü Biyoloji Anabilim Dalı Yüksek Lisans Tezi.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Hassine, D. B., Khlifi, D., Ferhout, H., Raoelison, E. G., &amp; Bouajila, J. (2016). Curry Plant (Helichrysum Sp.) Oils. Essential Oils İn Food Preservation, Flavor and Safety, 395-403.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">İnsel, B. (2019). Piyasada Ölmez Çiçek (Helichrysum Sp.) Olarak Satılan Kurutulmuş Bitki Örneklerinin Kalite Parametrelerinin Değerlendirilmesi (Master&#039;s Thesis, Sağlık Bilimleri Enstitüsü).</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">Anonim, (2021). Ölmez Çiçek (Helichrysum italicum) Tarımı ve Endüstrisi Fizibilite raporu, BAKA. https://www.kalkinmakutuphanesi.gov.tr/assets/upload/dosyalar/lmez-cicek-tarimi-ve-endustrisi-fizibilite-raporu.pdf</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">Eroğlu, H. E. (2018). Türkiye Helichrysum Taksonlarının Türkçe ve Diğer Dillerdeki İsimleri. Avrasya Terim Dergisi, 6(1), 26-34.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">Bianchini, A., Tomi, P., Costa, J., &amp; Bernardini, A. F. (2001). Composition of Helichrysum italicum (Roth) G. Don fil. subsp. italicum essential oils from Corsica (France). Flavour and fragrance journal, 16(1), 30-34.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">Maksimovic, S., Tadic, V., Skala, D., Zizovic, I. (2017). Separation of phytochemicals from Helichrysum italicum : An analysis of different isolation techniques and biological activity of prepared extracts. Phytochemistry, 138, 9-28.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">Miloradovic, Z., Glamoclija, D., Popovic, V., Jovanovic, L., Popovic, S., Ugrenovic, V., &amp; Filipovic, V. (2018). Fresh yield biomass immortelle and essential oils contents depending on the growing locality. In Proceeding of the Eco-Conference: Ecological Movement of Novi Sad, Novi Sad, Serbia (pp. 26-28).</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">Anonymus, (2021). https://www.syngentaflowers-us.com/sites/g/files/zhg721/f/media/2020/03/05/culture_vegetative_curryplant_helichrysumitalicum.pdf.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">Jovović, Z., Salkić, B., Velimirović, A., Vukićević, P., &amp; Salkić, A. (2018). Production of immortelle seedlings according to the principles of organic production. International Journal of Plant &amp; Soil Science, 21(6), 1-5.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">Pohajda I.. Dragun G.. Puharić-Visković N. (2015). Smilje. Savjetodavna služba. Zagreb.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">Čagalj, M., Grgić, I., Zrakić, M., &amp; Ivanković, M. (2019). Economic evaluation (efficiency) of investment in organically grown immortelle [Helichrysum italicum ssp. italicum] in Bosnia and Herzegovina. The first report from Mediterranean. Journal of Central European Agriculture, 20(1), 524-541.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">Stepanović B, Radanović D, Turšić I, Nemčević N, Ivanec J. (2009). Uzgoj ljekovitog i aromatičnog bilja. Jan-Spider d.o.o.,Pitomača.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">Jočić, A., (2017). Efficiency of new liquid fertilizers chap liquid in immortelle plantation production system (Helichrysum italicum (Roth) G. Don fil.). Proceedings conference of agronomy students with international participation, 451.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">Bahadırlı, N. P., Yıldırım, M. U., &amp; Sarıhan, E. O. (2024). Diurnal, and seasonal dynamics in essential oil content and composition of cultivated Helichrysum italicum (Roth) G. Don. Biochemical Systematics and Ecology, 117, 104888.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">Ostojić, I., Zovko, M., Petrović, D., &amp; Bošnjak, L. (2018). Štetnıcı Smılja [Helichrysum İtalicum (Roth) G. Don.] U Plantažnom Uzgoju Na Području Hercegovıne. Fragmenta Phytomedica, 32(1), 21-30.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">Wrzesıńska, D., Sawılska, A, K. (2010). Butterflies infesting dwarf everlast [Helichrysum arenarium (L.) Moench]. Prog. Plant Prot., Vol. 50, 3: 1322‐1326.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">Perrini R, Morone-Fortunato I, Lorusso E, Avato P. (2009). Glands, essential oils and in vitro establishment of Helichrysum italicum (Roth) G. Don ssp. italicum. Ind. Crop. Prod. 29:395-403.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">Roussis, V., Tsoukatou, M., Petrakis, P. V., Chinou, I., Skoula, M., &amp; Harborne, J. B. (2000). Volatile constituents of four Helichrysum species growing in Greece. Biochemical Systematics and Ecology, 28(2), 163-175.</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">Bianchini, A., Tomi, P., Bernardini, A. F., Morelli, I., Flamini, G., Cioni, P. L., ... &amp; Marchetti, M. (2003). A comparative study of volatile constituents of two Helichrysum italicum (Roth) Guss. Don Fil subspecies growing in Corsica (France), Tuscany and Sardinia (Italy). Flavour and fragrance journal, 18(6), 487-491.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">Rossi, P. G., Berti, L., Panighi, J., Luciani, A., Maury, J., Muselli, A., ... &amp; Bolla, J. M. (2007). Antibacterial action of essential oils from Corsica. Journal of Essential Oil Research, 19(2), 176-182.</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">Kladar, N. V., Anačkov, G. T., Rat, M. M., Srđenović, B. U., Grujić, N. N., Šefer, E. I., &amp; Božin, B. N. (2015). Biochemical characterization of Helichrysum italicum (Roth) G. Don subsp. italicum (Asteraceae) from Montenegro: Phytochemical screening, chemotaxonomy, and antioxidant properties. Chemistry &amp; biodiversity, 12(3), 419-431.</mixed-citation>
                    </ref>
                                    <ref id="ref30">
                        <label>30</label>
                        <mixed-citation publication-type="journal">Leonardi M, Ambryszewska KE, Melai B, Flamini G, Cioni PL, Parri F, Pistelli L. (2013). Essential-oil composition of Helichrysum italicum (Roth) G.Don ssp. italicum from Elba Island (Tuscany, Italy). Chem Biodivers. 10(3):343-55. doi: 10.1002/cbdv.201200222. PMID: 23495152.</mixed-citation>
                    </ref>
                                    <ref id="ref31">
                        <label>31</label>
                        <mixed-citation publication-type="journal">Melito, S., Petretto, G. L., Podani, J., Foddai, M., Maldini, M., Chessa, M., &amp; Pintore, G., (2016). Altitude and climate influence Helichrysum italicum subsp. microphyllum essential oils composition. Industrial Crops and Products, 80, 242-250.</mixed-citation>
                    </ref>
                                    <ref id="ref32">
                        <label>32</label>
                        <mixed-citation publication-type="journal">Kılıçarslan, G. (2020). İstanbul Silivri ve İzmir Menemen Bölgesinde Kültürü Yapılan Helichrysum Italıcum (Roth) Guss. Don. Bitkisinin Uçucu Yağı Ve Sıvı Ekstrelerinin Karşılaştırılması Bezmialem Vakıf Üniversitesi Sağlık Bilimleri Enstitüsü Farmakognozi Ve Doğal Ürünler Kimyası Anabilim Dalı Farmakognozi Ve Doğal Ürünler Kimyası Programı Yüksek Lisans Tezi.</mixed-citation>
                    </ref>
                                    <ref id="ref33">
                        <label>33</label>
                        <mixed-citation publication-type="journal">Jerković, I., Rajić, M., Marijanović, Z., Bilić, M., &amp; Jokić, S. (2016). Optimization of supercritical CO2 extraction of dried Helichrysum italicum flowers by response surface methodology: GC-MS profiles of the extracts and essential oil. Separation Science and Technology, 51(18), 2925-2931.</mixed-citation>
                    </ref>
                                    <ref id="ref34">
                        <label>34</label>
                        <mixed-citation publication-type="journal">Djihane, B., Wafa, N., Elkhamssa, S., Maria, A. E., &amp; Mihoub, Z. M. (2017). Chemical constituents of Helichrysum italicum (Roth) G. Don essential oil and their antimicrobial activity against Gram-positive and Gram-negative bacteria, filamentous fungi and Candida albicans. Saudi Pharmaceutical Journal, 25(5), 780-787.</mixed-citation>
                    </ref>
                                    <ref id="ref35">
                        <label>35</label>
                        <mixed-citation publication-type="journal">Viegas, D. A., Palmeira-de-Oliveira, A., Salgueiro, L., Martinez-de-Oliveira, J., &amp; Palmeira-de-Oliveira, R. (2014). Helichrysum italicum: From traditional use to scientific data. Journal of ethnopharmacology, 151(1), 54-65.</mixed-citation>
                    </ref>
                                    <ref id="ref36">
                        <label>36</label>
                        <mixed-citation publication-type="journal">Rigano, D., Formisano, C., Pagano, E., Senatore, F., Piacente, S., Masullo, M., ... &amp; Borrelli, F. (2014). A new acetophenone derivative from flowers of Helichrysum italicum (Roth) Don ssp. italicum. Fitoterapia, 99, 198-203.</mixed-citation>
                    </ref>
                                    <ref id="ref37">
                        <label>37</label>
                        <mixed-citation publication-type="journal">Scarborough,J.,(1978).Theophrastus on herbals and herbal remedies. J. Hist. Biol. 11, 353–385.</mixed-citation>
                    </ref>
                                    <ref id="ref38">
                        <label>38</label>
                        <mixed-citation publication-type="journal">Bahadırlı NP. (2022). Herdemyeşil sanguineum (L.) Kostel&#039;in ticari açıdan genişlemesinin değerlendirilmesi. Tıbbi VeAromatik Bitkilerin Fonksiyonel Kullanım Alanları, Ticareti Ve Sürdürülebilirliği (Ed: Rüveyde Tunçtürk) (İçindeTürkçe).</mixed-citation>
                    </ref>
                                    <ref id="ref39">
                        <label>39</label>
                        <mixed-citation publication-type="journal">Yabalak, E., Bahadırlı, N. P., Yetkin, D., Yaldız, F. D., &amp; Han Türkseven, Ç. (2024). Unlocking nature’s potential: anticancer potential of Helichrysum sanguineum (L.) Kostel on breast cancer cells and its chemical composition. International Journal of Environmental Health Research, 1-13.</mixed-citation>
                    </ref>
                                    <ref id="ref40">
                        <label>40</label>
                        <mixed-citation publication-type="journal">Quer, P.F., (1993). Plant as Medicinales, El Dioscórides Renovado,14 th ed. Editoral Labor, S.A., Barcelona.</mixed-citation>
                    </ref>
                                    <ref id="ref41">
                        <label>41</label>
                        <mixed-citation publication-type="journal">Lourens, A. C., Viljoen, A. M., van Heerden, F. R., (2008). South African Helichrysum species: a review of the traditional uses, biological activity and phytochemistry. J. Ethnopharmacol. 119,630–652.</mixed-citation>
                    </ref>
                                    <ref id="ref42">
                        <label>42</label>
                        <mixed-citation publication-type="journal">Babotă, M., Mocan, A., Vlase, L., Crișan, O., Ielciu, I., Gheldiu, A. M., ... &amp; Păltinean, R. (2018). Phytochemical analysis, antioxidant and antimicrobial activities of Helichrysum arenarium (L.) Moench. and Antennaria dioica (L.) Gaertn. flowers. Molecules, 23(2), 409.</mixed-citation>
                    </ref>
                                    <ref id="ref43">
                        <label>43</label>
                        <mixed-citation publication-type="journal">Albayrak, S., Aksoy, A., Sagdic, O., &amp; Hamzaoglu, E. (2010). Compositions, antioxidant and antimicrobial activities of Helichrysum (Asteraceae) species collected from Turkey. Food chemistry, 119(1), 114-122.</mixed-citation>
                    </ref>
                                    <ref id="ref44">
                        <label>44</label>
                        <mixed-citation publication-type="journal">Musabayane, C. T., Munjeri, O., &amp; Mdege, N. D. (2003). Effects of Helichrysum ceres Extracts on Renal. Renal failure, 25(1), 5-14.</mixed-citation>
                    </ref>
                                    <ref id="ref45">
                        <label>45</label>
                        <mixed-citation publication-type="journal">Onaran, M., Orhan, N., Farahvash, A., Ekin, H. N., Kocabıyık, M., Gönül, İ. I., ... &amp; Aslan, M. (2016). Successful treatment of sodium oxalate induced urolithiasis with Helichrysum flowers. Journal of ethnopharmacology, 186, 322-328.</mixed-citation>
                    </ref>
                                    <ref id="ref46">
                        <label>46</label>
                        <mixed-citation publication-type="journal">Coşar, G., Çubukçu, B., (1990). Antibacterial activity of Helichrysum species growing in Turkey, Fitoterapia; LXI: 161–4.</mixed-citation>
                    </ref>
                                    <ref id="ref47">
                        <label>47</label>
                        <mixed-citation publication-type="journal">Rančić, A., Soković, M., Vukojević, J., Simić, A., Marin, P., Duletić-Laušević, S., &amp; Djoković, D. (2005). Chemical composition and antimicrobial activities of essential oils of Myrrhis odorata (L.) Scop, Hypericum perforatum L and Helichrysum arenarium (L.) Moench. Journal of Essential Oil Research, 17(3), 341-345.</mixed-citation>
                    </ref>
                                    <ref id="ref48">
                        <label>48</label>
                        <mixed-citation publication-type="journal">Aslan, M., Katircioglu, H., Orhan, I., Atici, T., &amp; Sezik, E. (2007). Antibacterial potential of the capitula of eight Anatolian Helichrysum species. Turk J Pharm Sci, 4(2), 71-77.</mixed-citation>
                    </ref>
                                    <ref id="ref49">
                        <label>49</label>
                        <mixed-citation publication-type="journal">Chinou, I. B., Roussis, V., Perdetzoglou, D., Tzakou, O., &amp; Loukis, A. (1997). Chemical and Antibacterial Studies of two Helichrysum Species of Greek Origin1. Planta medica, 63(02), 181-183.</mixed-citation>
                    </ref>
                                    <ref id="ref50">
                        <label>50</label>
                        <mixed-citation publication-type="journal">Sobhy, E. A., &amp; El-Feky, S. S. (2007). Chemical constituents and antimicrobial activity of Helichrysum stoechas. Asian journal of plant sciences.</mixed-citation>
                    </ref>
                                    <ref id="ref51">
                        <label>51</label>
                        <mixed-citation publication-type="journal">Mollova, S., Fidan, H., Antonova, D., Bozhilov, D., Stanev, S., Kostova, I., &amp; Stoyanova, A. (2020). Chemical composition and antimicrobial and antioxidant activity of Helichrysum italicum (Roth) G. Don subspecies essential oils. Turkish journal of agriculture and forestry, 44(4), 371-378.</mixed-citation>
                    </ref>
                                    <ref id="ref52">
                        <label>52</label>
                        <mixed-citation publication-type="journal">Oliva, A., Garzoli, S., Sabatino, M., Tadić, V., Costantini, S., Ragno, R., &amp; Božović, M. (2020). Chemical composition and antimicrobial activity of essential oil of Helichrysum italicum (Roth) G. Don fil. (Asteraceae) from Montenegro. Natural product research, 34(3), 445-448.</mixed-citation>
                    </ref>
                                    <ref id="ref53">
                        <label>53</label>
                        <mixed-citation publication-type="journal">Bacıc, A., Prazına, N., Hadzıc-Hasanovıc, V., Dacıc, M., Ajanovıć, A. And Mahmutovıc, O. (2021). Chemıcal Composıtıon and Antımıcrobıal Actıvıty of The Essentıal Oıl Of Helichrysum İtalicum (Roth) G. Don From Bosnıa And Herzegovına. Plant Cell Biotechnology and Molecular Biology 22(49&amp;50):67-73.</mixed-citation>
                    </ref>
                                    <ref id="ref54">
                        <label>54</label>
                        <mixed-citation publication-type="journal">Bouchaala, M., Ramdani, M., Lograda, T., Chalard, P., &amp; Figueredo, G. (2017). Chemical composition, antibacterial activity and chromosome number of Helichrysum lacteum, endemic from Algeria. Int. J. Pharma Res. Health. Sci, 5(1), 1539-1545.</mixed-citation>
                    </ref>
                                    <ref id="ref55">
                        <label>55</label>
                        <mixed-citation publication-type="journal">Eksi, M., Sevgi, O., Akburak, S., Yurtseven, H., &amp; Esin, I. (2020). Assessment of recycled or locally available materials as green roof substrates. Ecological Engineering, 156, 105966.</mixed-citation>
                    </ref>
                                    <ref id="ref56">
                        <label>56</label>
                        <mixed-citation publication-type="journal">Başer, K.H.C. (2015). Ölmezçiçek (Helichrysum Mill.). Bağ Bahçe 58: 16-18.</mixed-citation>
                    </ref>
                                    <ref id="ref57">
                        <label>57</label>
                        <mixed-citation publication-type="journal">Voinchet V, Giraud-Robert AM., (2007). Utilisation de l’huile essentielle d’hélichryse italienne et de l’huile végétale de rose musquée après intervention de chirurgie plastique réparatrice et esthétique. Phytothérapie. 5: 67-72.</mixed-citation>
                    </ref>
                                    <ref id="ref58">
                        <label>58</label>
                        <mixed-citation publication-type="journal">Guinoiseau, E., Lorenzi, V., Luciani, A., Muselli, A., Costa, J., Casanova, J., &amp; Berti, L. (2013). Biological properties and resistance reversal effect of Helichrysum italicum (Roth) G. Don. Microbial pathogens and strategies for combating them: science, technology and education, 2, 1073-1080.</mixed-citation>
                    </ref>
                                    <ref id="ref59">
                        <label>59</label>
                        <mixed-citation publication-type="journal">Lawless J. (2002). The Encyclopedia of Essential Oils. London: Thorsons. p107.</mixed-citation>
                    </ref>
                                    <ref id="ref60">
                        <label>60</label>
                        <mixed-citation publication-type="journal">Catty S. (2001). Hydrosols: the next Aromatherapy. Vermont: Healing Arts Press. p96–97.</mixed-citation>
                    </ref>
                                    <ref id="ref61">
                        <label>61</label>
                        <mixed-citation publication-type="journal">Mathekga, A., Meyer, J.J.M., Horn, M.M., Drewes, S.E., (2000). An acylated phloroglucinol with antimicrobial properties from Helichrysum caespititium. Phytochemistry 53, 93–96.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
