The Role of Inflammatory Markers and the Modified Systemic Inflammatory Score in Bethesda Category 3 And 4 Patients for Prediction of Malignancy

Year 2022, Volume: 5 Issue: 3, 471 - 475, 01.09.2022

Sönmez Ocak Ömer Faruk Bük Ahmet Can Sarı Ahmet Burak Çiftci

https://doi.org/10.19127/bshealthscience.1122731

Abstract

Management of Bethesda Category 3 and 4 patients remains a challenge. The modified systemic inflammatory score (mSIS) and other inflammatory parameters are used for prognosis assessment in various cancers. This retrospective study aims to explore prediction strength of the inflammatory parameters in Category 3 and 4 patients. One hundred and twenty three patients had undergone thyroidectomy for Category 3 and 4 fine needle aspiration biopsy (FNAB). The data of inflammatory markers including Neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), albumin to globulin ratio (AGR) and mSIS were evaluated retrospectively. There were no statistically significant difference in inflammatory parameters between benign and malignant patients and none of the inflammatory parameters had predictivity for thyroid cancer. Also in mSIS groups, thyroid cancer incidence were similar (P=0.684). Inflammatory parameters and mSIS were failed to predict thyroid cancer in patients who had category 3 and 4 FNAB.

Keywords

Thyroid cancer, Systemic inflammatory score, Albumin, Inflammation, Neutrophil to lymphocyte ratio, Fine needle aspiration biopsy

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