Hücre İçi Kalsiyum Sinyali, Apoptoz ve Kanser Progresyonunda Kalsiyum Kanallarının (Voc, Trp ve Soc Kanalları) Rolü

Yıl 2017, Cilt: 4 Sayı: 3, 1021 - 1027, 30.09.2017

Nihal Çiftçi

Öz

Intracellular calcium signaling is associated with cardiovascular and neurological diseases and many other diseases. Altered expression of calcium influx channels is associated with various types of cancer including breast, colon, prostate, ovary, brain. While important for regulating many normal, cellular processes, increases in intracellular Ca+2 have been implicated in a variety of processes associated with tumour progression, including breast cancer cell migration and proliferation. Studies comparing cancer tissues with noncancerous tissues have revealed changes in calcium signaling mediated by some members of the calcium channel family (voc, trp and soc channels). As we pointed out, altered expression of calcium channels plays a role in cancer progression. This review focuses on the recent studies regarding the differences in protein expression of calcium channels found in plasma membrane of cancer cells.

Anahtar Kelimeler

Calcium ion (Ca+2), Calcium Channels, Cancer

Hücre İçi Kalsiyum Sinyali, Apoptoz ve Kanser Progresyonunda Kalsiyum Kanallarının (Voc, Trp ve Soc Kanalları) Rolü

Öz

Hücre içi Ca⁺² sinyali
kardiyovasküler ve nörolojik hastalıklarla ve daha pek çok hastalıkla
ilişkilidir. Ca⁺² giriş kanallarının değişmiş ekspresyonları da
meme, kolon, prostat, over, beyin gibi çeşitli kanser tipleri ile
ilişkilendirilmektedir. Hücre içi Ca⁺² artışları pek çok hücresel
proseste önemli iken, kanserli bir olguda hücre proliferasyonu ve migrasyonu
dahil olmak üzere tümör progresyonu ile ilişkili olan pek çok proses için de
önemli ve etkilidir. Kanser ve kanser kökenli olmayan hücreleri karşılaştıran çalışmalar,
kalsiyum kanal ailesinin (Voc, Trp ve Soc kanalları) bazı üyelerinin aracılık
ettiği Ca⁺²-aracılı değişiklikleri ortaya koymaktadır. Kanser
progresyonunda kalsiyum kanallarının değişmiş ekspresyonunun rol oynadığı
dikkat çekmektedir. Bu derlemede kanser
hücrelerinin plazma zarında bulunan kalsiyum kanallarının protein
ekspresyonlarındaki değişiklikler ve sonuçları son yapılan çalışmalarla ifade
edilmektedir.

Anahtar Kelimeler

Kalsiyum iyonu (Ca+2), Kalsiyum Kanalları, Kanser

Kaynakça

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