The Determination of IL-6 rs1800795 Polymorphism Distribution in Turkish National Cross-Country Skiing Athletes Sub-groups Created Referring to the 1km CCSTAs

Year 2021, Volume: 11 Issue: 4, 782 - 786, 26.10.2021

Derya Kazancı Tolga Polat Canan Sercan Doğan Beste Tacal Aslan Şehkar Oktay Muhammed Fatih Bilici Ömer Kaynar Başak Funda Eken Korkut Ulucan

https://doi.org/10.33808/clinexphealthsci.904524

Abstract

Objective: Interleukin-6 (IL-6) is an effective and functional protein with a cytokine structure. IL-6 is effective in the immune system like a pro/anti-inflammatory response, and muscle tissue hypertrophy and repair. Our study aimed to investigate the IL-6 rs1800795 polymorphism distribution in Turkish National Cross-Country Skiing Athletes and to determine the advantageous genotype for endurance performance.
Methods: 34 athletes within 3 groups; General (Group-1), Women (Group-2), and Men (Group-3) were enrolled to the study. Also each groups were divided into sub-groups according to their “1-kilometer cross-country average skiing-times (1 km-CCSTAs)”. Blood samples were used for DNA isolation and genotyping were completed by real time- PCR.
Results: The groups' 1 km-CCSTAs were 188.7 ± 22.4, 212.3 ± 17.8, and 177.4 ± 14.1 seconds, respectively. We detected the genotypes as 17 GG (50%) and 17 GC (50%) in Group-1; 5 GG (45%) and 6 GC (55%) in Group-2; 12 GG (52%) and 11 GC (48%) in Group- 3. We detected no CC genotype in groups. Chi-square Fisher’s test was used for statistical analysis.
Conclusion: An increased GC genotype ratio was detected in the faster sub-groups of each group compared to the slower sub-groups. But we obtained the significant genotype distribution only in Group-3 (p <0.0001). Also, an increased C-allele frequency was detected in the faster sub-groups. However, the significant allele gene distribution was obtained only in Group-3 (p=0.0002). According to our results, we can speculate that the GC genotype is more advantageous than the GG genotype in Cross-Country Skiing Athletes.

Keywords

IL-6 genotypes, cross-country skiing, endurance, athletic performance, sports genetics

Supporting Institution

Marmara University Scientific Research Projects Coordination Unit

Project Number

FEN-C-DRP-101018-0535

Thanks

This work has been supported by Marmara University Scientific Research Projects Coordination Unit under grant number

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