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Salmonella ishali olan immün yetmezlikli bir olguda oral immünoglobulin tedavisi

Year 2013, Volume: 35 Issue: 4, 600 - 604, 09.03.2013

Fatma Duksal Utku Aygüneş Fatih Bolat Mehmet Oflaz Ömer Cevit

Abstract

Özet

Enfeksiyon ilişkili gastroenteritte en sık tanımlanan patojen virüslerden sonra salmonelladır. Salmonella’ya bağlı enfeksiyonlarda akut faz reaktanlarında artış ve ateş daha fazla görülmektedir. Salmonella enteropatojenik gram negatif basil olup lokalize enfeksiyondan sistemik enfeksiyona kadar değişen enfeksiyonlara yol açabilmektedir. En sık görülen şekli kendini sınırlayan komplike olmayan gastroenterittir. Rotavirüs ishali de Salmonella ishali gibi genel olarak kendini sınırladığı halde, bağışıklık sistemi baskılanmış hastalarda daha uzun ve ciddi seyredebilir. Daha çok rotavirüs ishallerinde yapılan çalışmalarda, verilen oral immünoglobulinin ishal süresini, semptomların şiddetini ve viral atılımı azalttığı gösterilmiştir. Salmonella ishalinde oral immünoglobilin verildiğini gösteren bir çalışmaya rastlamadık. Bu sunumda bağışıklık sistemi baskılanmış bir olguda Salmonella’ya bağlı ağır ishalin oral immünoglobulin ile tedavisi tartışılmıştır.

Anahtar sözcükler: İshal, Salmonella enfeksiyonları, oral immunoglobulin

 

Abstract

The most frequently identified pathogen, after viral pathogens, associated with infectious gastroenteritis is Salmonella. Increase in acute-phase reactants and fever are more frequently seen due to Salmonella infection. Salmonella, which is an enteropathogenic gram-negative bacilli causes infections ranging from localized to systemic infection. The most common form of Salmonella infection is uncomplicated self-limited gastroenteritis. In general, although rotavirus diarrhea like Salmonella diarrhea is limited by itself, it may cause a long and severe diarrhea in immunosuppressed patients. In the studies which have been done more with rotavirüs diarrhea, it was seen that, oral immunoglobulin reduced the severity of symptoms and of viral excretion. We did not find a study showing given oral immünogobilin in Salmonella diarrhea. In this presentation it is discussed oral immunoglobulin treatment in an immunosuppressed patient who had severe diarrhea due to Salmonella infection.

Keywords: Diarrhea, Salmonella infections, oral immunoglobulin

Keywords

Diarrhea Salmonella infections oral immunoglobulin

References

  • Weigering V, Kaiser J, Tapped D, Weissbuch B, Morbach H, Girschick HJ. Gastroenteritis in childhood: A retrospective study of 650 hospitalized pediatric patients. Int J Infect Dis 2011; 15: 401-7.
  • Erol I. Zoonotic importance of salmonella infections. Turkiye Klinikleri J Vet Sci 2010; 1: 105-13.
  • Kaistha N, Gupta V, Sidhu S, Chander J. Salmonella-salmonellosis-rare presentations of a common pathogen. Asian Pac J Trop Med 2011; 4: 417-20. Akcelik M, Akkoc N. Molecular mechanisms of salmonella pathogenicity: Review. Turkiye Klinikleri J Med Sci 2010; 30: 312-22.
  • Casadesus J. Salmonella: From basic science to clinical issues. Future microbiol 2011; 6: 133-5.
  • McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V. Salmonella takes control-driven manipulation of the host. Curr Opin Microbiol 2009; 12: 117Ozen M, Celiloglu C. (Salmonella infections in childhood). Turkiye Klinikleri J Pediatr Sci 2007; 3: 12-7.
  • Sireli UT. (An overwiev and regulations about salmonella infections). Turkiye Klinikleri J Vet Sci 2010; 1: 114-20.
  • Toprak D, Soysal A, Türel O, Bakır M. (Oral human serum immunoglobulin in rotavirüs diarrhea: Two case reports). Cocuk Enf Derg 2007; 1: 115-7.
  • Guarino A, Canani RB, Russo S, Albano F, Canani MB, Ruggeri FM, Donelli G, Rubino A. Oral immunoglobulins for treatment of acute rotaviral gastroenteritis. Pediatrics 1994; 93: 12-6.
  • Makay M, Olmez D, Unsal E, Anal O. Common variable immunodeficiency mimicking systemic-onset juvenile idiopathic arthritis: Differential diagnosis. Turkiye Klinikleri J Med Sci 2009; 29: 775-7.
  • Bakare N, Menschik D, Tiernan R, Hua W, Martin D. Severe combined immunodeficiency (SCID) and rotavirus vaccination: Reports to the Vaccine Adverse Events Reporting System (VAERS). Vaccine 2010; 28: 6609-12.
  • Buckley HR. Primary cellular immunodeficiencies. J Allergy Clin Immunol 2002; 109: 747-57.
  • Trevino M, Prieto E, Penalver D, Aguilera A, Garcia-Zarate A, GarciaRiestra C, Regueiro BJ. Diarrhea caused by adenovirus and astrovirus in hospitalized immunodeficient patients. Enferm Infecc Microbiol Clin 2001; 19: 7-10.
  • Jacobs JL, Gold JW, Murray HW, Roberts RB, Armstrong D. Salmonella infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1985; 102: 186-8.
  • Gotuzzo E, Frisancho O, Sanchez J, Liendo G, Carrillo C, Black RE, Morris JG Jr. Association between the acquired immunodeficiency syndrome and infection with salmonella typhi or salmonella paratyphi in an endemic typhoid area. Arch Intern Med 1991; 151: 381-2.
  • Shimoni Z, Pitlik S, Leibovici L, Samra Z, Konigsberger H, Drucker M, Agmon V Ashkenazi S, Weinberger M. Nontyphoid salmonella bacteremia: Age-related differences in clinical presentation, bacteriology, and outcome. Clin. Infect. Dis 1999; 28: 822-7.
  • Coon C, Beagley KW, Bao S. The role of granulocyte macrophage-colony stimulating factor in gastrointestinal immunity to salmonellosis. Scand J Immunol 2009; 70: 106-15.
  • Brandtzaeg, P. Role of secretory antibodies in the defence against infections. Int. J. Med. Microbiol 2003; 293: 3-15.
  • Martinoli C, Chiavelli A, Rescigno M. Entry route of salmonella typhimurium directs the type of induced immune response. Immunity 2007; 27: 975-84.
  • Michetti P, Mahan MJ, Slauch JM, Mekalanos JJ, Neutra MR. Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen salmonella typhimurium. Infect Immun 1992; 60: 1786-92. Rahimi S, Shiraz ZM, Salehi TZ, Torshizi MAK, Grimes JL. Prevention of salmonella infection in poultry by specific egg-derived antibody. Int. J. Poult Sci. 2007; 6: 230-5.
  • Kantele A,Arvilommi H, Jokinen I. Specific immunoglobulin-secreting human blood cells after peroral vaccination against Salmonella typhi. J. Infect. Dis 1986; 153: 1126-31.
  • Cancellieri V, Fara GM. Demonstration of specific IgA in human feces after immunization with live Ty2la salmonella typhi vaccine. J. Infect. Dis 1985; 151: 482-4.
  • Guarino A, Albano F, Canani RB, Bruzzese E. HIV, fatal rotavirus infection, and treatment options. The Lancet 2002; 359: 74.

Salmonella ishali olan immün yetmezlikli bir olguda oral immünoglobulin tedavisi

Year 2013, Volume: 35 Issue: 4, 600 - 604, 09.03.2013

Fatma Duksal Utku Aygüneş Fatih Bolat Mehmet Oflaz Ömer Cevit

Abstract

Özet

Enfeksiyon ilişkili gastroenteritte en sık tanımlanan patojen virüslerden sonra salmonelladır. Salmonella’ya bağlı enfeksiyonlarda akut faz reaktanlarında artış ve ateş daha fazla görülmektedir. Salmonella enteropatojenik gram negatif basil olup lokalize enfeksiyondan sistemik enfeksiyona kadar değişen enfeksiyonlara yol açabilmektedir. En sık görülen şekli kendini sınırlayan komplike olmayan gastroenterittir. Rotavirüs ishali de Salmonella ishali gibi genel olarak kendini sınırladığı halde, bağışıklık sistemi baskılanmış hastalarda daha uzun ve ciddi seyredebilir. Daha çok rotavirüs ishallerinde yapılan çalışmalarda, verilen oral immünoglobulinin ishal süresini, semptomların şiddetini ve viral atılımı azalttığı gösterilmiştir. Salmonella ishalinde oral immünoglobilin verildiğini gösteren bir çalışmaya rastlamadık. Bu sunumda bağışıklık sistemi baskılanmış bir olguda Salmonella’ya bağlı ağır ishalin oral immünoglobulin ile tedavisi tartışılmıştır.

Anahtar sözcükler: İshal, Salmonella enfeksiyonları, oral immunoglobulin

 

Abstract

The most frequently identified pathogen, after viral pathogens, associated with infectious gastroenteritis is Salmonella. Increase in acute-phase reactants and fever are more frequently seen due to Salmonella infection. Salmonella, which is an enteropathogenic gram-negative bacilli causes infections ranging from localized to systemic infection. The most common form of Salmonella infection is uncomplicated self-limited gastroenteritis. In general, although rotavirus diarrhea like Salmonella diarrhea is limited by itself, it may cause a long and severe diarrhea in immunosuppressed patients. In the studies which have been done more with rotavirüs diarrhea, it was seen that, oral immunoglobulin reduced the severity of symptoms and of viral excretion. We did not find a study showing given oral immünogobilin in Salmonella diarrhea. In this presentation it is discussed oral immunoglobulin treatment in an immunosuppressed patient who had severe diarrhea due to Salmonella infection.

Keywords: Diarrhea, Salmonella infections, oral immunoglobulin

Keywords

İshal Salmonella enfeksiyonları oral immunoglobulin

References

  • Weigering V, Kaiser J, Tapped D, Weissbuch B, Morbach H, Girschick HJ. Gastroenteritis in childhood: A retrospective study of 650 hospitalized pediatric patients. Int J Infect Dis 2011; 15: 401-7.
  • Erol I. Zoonotic importance of salmonella infections. Turkiye Klinikleri J Vet Sci 2010; 1: 105-13.
  • Kaistha N, Gupta V, Sidhu S, Chander J. Salmonella-salmonellosis-rare presentations of a common pathogen. Asian Pac J Trop Med 2011; 4: 417-20. Akcelik M, Akkoc N. Molecular mechanisms of salmonella pathogenicity: Review. Turkiye Klinikleri J Med Sci 2010; 30: 312-22.
  • Casadesus J. Salmonella: From basic science to clinical issues. Future microbiol 2011; 6: 133-5.
  • McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V. Salmonella takes control-driven manipulation of the host. Curr Opin Microbiol 2009; 12: 117Ozen M, Celiloglu C. (Salmonella infections in childhood). Turkiye Klinikleri J Pediatr Sci 2007; 3: 12-7.
  • Sireli UT. (An overwiev and regulations about salmonella infections). Turkiye Klinikleri J Vet Sci 2010; 1: 114-20.
  • Toprak D, Soysal A, Türel O, Bakır M. (Oral human serum immunoglobulin in rotavirüs diarrhea: Two case reports). Cocuk Enf Derg 2007; 1: 115-7.
  • Guarino A, Canani RB, Russo S, Albano F, Canani MB, Ruggeri FM, Donelli G, Rubino A. Oral immunoglobulins for treatment of acute rotaviral gastroenteritis. Pediatrics 1994; 93: 12-6.
  • Makay M, Olmez D, Unsal E, Anal O. Common variable immunodeficiency mimicking systemic-onset juvenile idiopathic arthritis: Differential diagnosis. Turkiye Klinikleri J Med Sci 2009; 29: 775-7.
  • Bakare N, Menschik D, Tiernan R, Hua W, Martin D. Severe combined immunodeficiency (SCID) and rotavirus vaccination: Reports to the Vaccine Adverse Events Reporting System (VAERS). Vaccine 2010; 28: 6609-12.
  • Buckley HR. Primary cellular immunodeficiencies. J Allergy Clin Immunol 2002; 109: 747-57.
  • Trevino M, Prieto E, Penalver D, Aguilera A, Garcia-Zarate A, GarciaRiestra C, Regueiro BJ. Diarrhea caused by adenovirus and astrovirus in hospitalized immunodeficient patients. Enferm Infecc Microbiol Clin 2001; 19: 7-10.
  • Jacobs JL, Gold JW, Murray HW, Roberts RB, Armstrong D. Salmonella infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1985; 102: 186-8.
  • Gotuzzo E, Frisancho O, Sanchez J, Liendo G, Carrillo C, Black RE, Morris JG Jr. Association between the acquired immunodeficiency syndrome and infection with salmonella typhi or salmonella paratyphi in an endemic typhoid area. Arch Intern Med 1991; 151: 381-2.
  • Shimoni Z, Pitlik S, Leibovici L, Samra Z, Konigsberger H, Drucker M, Agmon V Ashkenazi S, Weinberger M. Nontyphoid salmonella bacteremia: Age-related differences in clinical presentation, bacteriology, and outcome. Clin. Infect. Dis 1999; 28: 822-7.
  • Coon C, Beagley KW, Bao S. The role of granulocyte macrophage-colony stimulating factor in gastrointestinal immunity to salmonellosis. Scand J Immunol 2009; 70: 106-15.
  • Brandtzaeg, P. Role of secretory antibodies in the defence against infections. Int. J. Med. Microbiol 2003; 293: 3-15.
  • Martinoli C, Chiavelli A, Rescigno M. Entry route of salmonella typhimurium directs the type of induced immune response. Immunity 2007; 27: 975-84.
  • Michetti P, Mahan MJ, Slauch JM, Mekalanos JJ, Neutra MR. Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen salmonella typhimurium. Infect Immun 1992; 60: 1786-92. Rahimi S, Shiraz ZM, Salehi TZ, Torshizi MAK, Grimes JL. Prevention of salmonella infection in poultry by specific egg-derived antibody. Int. J. Poult Sci. 2007; 6: 230-5.
  • Kantele A,Arvilommi H, Jokinen I. Specific immunoglobulin-secreting human blood cells after peroral vaccination against Salmonella typhi. J. Infect. Dis 1986; 153: 1126-31.
  • Cancellieri V, Fara GM. Demonstration of specific IgA in human feces after immunization with live Ty2la salmonella typhi vaccine. J. Infect. Dis 1985; 151: 482-4.
  • Guarino A, Albano F, Canani RB, Bruzzese E. HIV, fatal rotavirus infection, and treatment options. The Lancet 2002; 359: 74.
There are 22 citations in total.

Details

Primary Language Turkish
Journal Section Case Reports
Authors

Fatma Duksal

Utku Aygüneş

Fatih Bolat

Mehmet Oflaz

Ömer Cevit

Publication Date March 9, 2013
Published in Issue Year 2013Volume: 35 Issue: 4

Cite

AMA Duksal F, Aygüneş U, Bolat F, Oflaz M, Cevit Ö. Salmonella ishali olan immün yetmezlikli bir olguda oral immünoglobulin tedavisi. CMJ. December 2013;35(4):600-604.