Function of Arginine Metabolism in Polycystic Ovary Syndrome

Year 2024, Volume: 1 Issue: 1, 43 - 47, 28.02.2024

Damla Binnetoğlu , Gökhan Can Çetin

https://doi.org/10.5281/zenodo.10712512

Abstract

Polycystic ovary syndrome (PCOS) is a common disease affecting women of reproductive age. PCOS, which is associated with reproductive system and metabolic disorders, may result from an abnormal oxidation state that subsequently causes inflammatory conditions. Antioxidants are thought to be the main factor playing a role in ovarian physiology, follicular growth, oocyte maturation, and ovarian steroid biosynthesis. Oxidative stress or low antioxidant status in the ovaries can be considered one of the most important mechanisms that paves the way for the development of PCOS. NO is formed by nitric oxide synthase (NOS), which converts L-arginine as a substrate to L-citrulline. In the light of today's literature, research on the roles of arginine metabolism, which interacts with NOS, in the pathophysiology of PCOS has been compiled.

Keywords

polycystic ovary syndrome, Arginin, polyamines

Ethical Statement

None

Supporting Institution

None

Project Number

None

Thanks

None

Polikistik Over Sendromunda Arjinin Metabolizmasının Fonksiyonu

Abstract

Polikistik over sendromu (PKOS), doğurganlık çağındaki kadınları etkileyen yaygın bir hastalıktır. Üreme ve metabolik bozukluklarla ilişkilendirilen PKOS daha sonra inflamatuar durumlara neden olan anormal oksidasyon durumundan kaynaklanabilmektedir. Antioksidanların over fizyolojisinde, foliküler büyümede, oosit olgunlaşmasında ve yumurtalık steroid biyosentezinde rol oynayan ana faktör olduğu düşünülmektedir. Overlerdeki oksidatif stres veya düşük antioksidan durumu, PKOS gelişimine zemin hazırlayan en önemli mekanizmalardan biri olarak kabul edilebilir. NO, substrat olarak L-arginin'i L-sitrulline dönüştüren nitrik oksit sentaz (NOS) tarafından oluşturulur. Günümüz literatürü ışığında NOS ile etkileşen arjininin metabolizmasının, PKOS patofizyolojisindeki rolleri üzerine yapılan araştırmalar derlenmiştir.

Keywords

polikistik over sendromu, Arjinin, poliaminler

Ethical Statement

yok

Supporting Institution

yok

Project Number

None

Thanks

yok

References

• Agarwal, A., Gupta, S., & Sharma, R. K. (2005). Role of oxidative stress in female reproduction. Reproductive biology and endocrinology: RB&E, 3, 28. https://doi.org/10.1186/1477-7827-3-28
• Alataş, E., Kılıç, D., & Güler, T. (2019). Güncel polikistik over sendromu değerlendirme ve yönetim rehberi doğrultusunda tanıdaki ‘yeniler’ ve ‘yineler’. Pamukkale Tıp Dergisi, 12(3), 595-602.
• Azziz R. (2018). Polycystic Ovary Syndrome. Obstetrics and gynecology, 132(2), 321–336. https://doi.org/10.1097/AOG.0000000000002698 Böger R. H. (2014). The pharmacodynamics of L-arginine. Alternative therapies in health and medicine, 20(3), 48–54.
• Dumesic, DA, Abbott DH. & Padmanabhan V. Polycystic ovary syndrome and its developmental origins. Rev. Endocr. Metab. Disord. 2007;8:127-41
• Harada M. (2022). Pathophysiology of polycystic ovary syndrome revisited: Current understanding and perspectives regarding future research. Reproductive medicine and biology, 21(1), e12487. https://doi.org/10.1002/rmb2.12487
• Hortu, İ., & Karadaş, N. (2019). Polikistik Over Sendromu Patofizyolojisi. Turkiye Klinikleri Gynecology Obstetrics-Special Topics, 12(5), 6-9.
• Hu, W., Xie, N., Pan, M., Zhang, Q., Zhang, H., Wang, F., & Qu, F. (2024). Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway. Journal of ethnopharmacology, 318, 117025. https://doi.org/10.1016/j.jep.2023.117025
• Karabulut, H., Gülay, M Ş. (2016). Serbest radikaller . MAKÜ Sag. Bil. Enst. Derg, 4(1), 50-59
• Karacaoğlu, F. (2015). Polikistik over sendromu ve periodontal sağlık arasındaki ilişki. J Dent Fac Atatürk Uni, 13, 64-71
• Kayın, G. B. (2020). Doktora tezi. Nitrik oksit uygulamasının biber bitkisinde (Capsicum annuum L.) kimi stres faktörleri üzerine etkisi. Bursa Uludağ Üniversitesi, Fen Bilimleri Enstitüsü, Türkiye
• Krishna, M. B., Joseph, A., Thomas, P. L., Dsilva, B., Pillai, S. M., & Laloraya, M. (2017). Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome. Cellular physiology and biochemistry :international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(5), 1880–1892. https://doi.org/10.1159/000484107
• Laleli, B. & Timur, B. (2021). Examination of Oxidative Stress Level in Adolescents with Polycystic Ovary Syndrome by Biochemical Parameters. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 10 (4) , 935-942 . DOI: 10.37989/gumussagbil.1003117
• Li, T., Zhang, T., Wang, H., Zhang, Q., Gao, H., Liu, R., & Yin, C. (2023). The ADMA-DDAH1 axis in ovarian apoptosis of polycystic ovary syndrome. The Journal of steroid biochemistry and molecular biology, 225, 106180. https://doi.org/10.1016/j.jsbmb.2022.106180
• Masha, A., Manieri, C., Dinatale, S., Bruno, G. A., Ghigo, E., & Martina, V. (2009). Prolonged treatment with N-acetylcysteine and L-arginine restores gonadal function in patients with polycystic ovary syndrome. Journal of endocrinological investigation, 32(11), 870–872. https://doi.org/10.1007/BF03345763
• Matsumoto, K., Yobimoto, K., Huong, N. T., Abdel-Fattah, M., Van Hien, T., & Watanabe, H. (1999). Psychological stress-induced enhancement of brain lipid peroxidation via nitric oxide systems and its modulation by anxiolytic and anxiogenic drugs in mice. Brain research, 839(1), 74–84. https://doi.org/10.1016/s0006-8993(99)01715-1
• Murri, M., Luque-Ramírez, M., Insenser, M., Ojeda-Ojeda, M., EscobarMorreale, H. F. (2013). Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Hum Reprod Update, 19(3), 268-88. Nathan C.Inducible nitric oxide synthese.What difference does it make. J Clin Invest 1997;100:2417-2423.
• Ozler, S., Oztas, E., Tokmak, A., et al. (2016). The association of thiol / disulphide homeostasis and lipid accumulation index with cardiovascul ar risk factors in overweight adolescents with polycystic ovary syndro me. Clin Endocrinol, 84(4), 516-23.
• Ragy, M. M., Abdel-Hamid, H. A., & Toni, N. D. M. (2019). Pathophysiological changes in experimental polycystic ovary syndrome in female albino rats: Using either hemin or L-arginine. Journal of cellular physiology, 234(6), 8426–8435. https://doi.org/10.1002/jcp.27757
• Roebuck, K. A. Oxidant stress regulation of IL-8 and ICAM1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB. Int J Mol Med 1999;4(3):223–30.
• Rosenfield, R. L., & Ehrmann, D. A. (2016). The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocrine reviews, 37(5), 467–520. https://doi.org/10.1210/er.2015-1104
• Rosselli, M., Keller, P. J., & Dubey, R. K. (1998). Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Human reproduction update, 4(1), 3–24. https://doi.org/10.1093/humupd/4.1.3
• Tiboni, G. M., & Ponzano, A. (2014). Nitric oxide and teratogenesis: an update. Current pharmaceutical design, 20(34), 5443–5447. https://doi.org/10.2174/1381612820666140205150437
• Tiwari, M., Prasad, S., Pandey, A. N., Premkumar, K. V., Tripathi, A., Gupta, A., Chetan, D. R., Yadav, P. K., Shrivastav, T. G., & Chaube, S. K. (2017). Nitric oxide signaling during meiotic cell cycle regulation in mammalian oocytes. Frontiers in bioscience (Scholar edition), 9(3), 307–318. https://doi.org/10.2741/s489
• Verit, F. F., & Erel, O. (2008). Oxidative stress in nonobese women with polycystic ovary syndrome: correlations with endocrine and screening parameters. Gynecologic and obstetric investigation, 65(4), 233–239. https://doi.org/10.1159/000113046
• Victor, V. M., Rocha, M., Bañuls, C., Alvarez, A., de Pablo, C., Sanchez-Serrano, M., Gomez, M., & Hernandez-Mijares, A. (2011). Induction of oxidative stress and human leukocyte/endothelial cell interactions in polycystic ovary syndrome patients with insulin resistance. The Journal of clinical endocrinology and metabolism, 96(10), 3115–3122. https://doi.org/10.1210/jc.2011-0651
• Xu, Y., & Qiao, J. (2022). Association of Insulin Resistance and Elevated Androgen Levels with Polycystic Ovarian Syndrome (PCOS): A Review of Literature. Journal of healthcare engineering, 9240569. https://doi.org/10.1155/2022/9240569
• Yildirim, M., Turkyilmaz, E., Neselioglu, S., Alisik, M., Avsar, A. F. (2017). Dynamic Thiol-Disulphide Status in Polycystic Ovary Syndrome and Its Association with the Pathogenesis of the Disease. Gynecol Obstet Invest, 82(1), 54-9.