Silibinin’in yüksek kolesterol diyeti ile beslenen sıçanlarda hiperlipidemi üzerine etkisi

Year 2021, Volume: 46 Issue: 1, 125 - 131, 31.03.2021

Didem Duman Abdullah Arpacı Emre Dirican Server Bozdoğan Hamidullah Suphi Bayraktar

Abstract

Amaç: Hipolipidemik ilaçlar mevcut olmasına rağmen, daha etkin bir hipolipidemik ajan arayışı devam etmektedir. Bu nedenle, bu çalışmada yüksek kolesterol diyeti ile beslenen sıçanlarda Silibinin hiperlipidemiye olan etkisinin araştırılması amaçlanmıştır.
Gereç ve Yöntem: Öncelikle deney grubundaki sıçanlar obez hale getirilmiştir. Sıçanlara 60 gün boyunca yumurta sarısı verilmiş ve daha sonra 50 mg/kg ve 100 mg/kg Silibin i.p. olarak 7 gün boyunca uygulanmıştır.
Bulgular: Sıçanların ilk ve son kiloları arasında anlamlı bir fark bulunmuştur. Çalışmamızda yüksek kolesterollü diyet ile beslenen grupların total kolesterol (TK), LDL ve trigliserit (TG), VLDL seviyeleri, kontrol grubuna kıyasla anlamlı bir şekilde yükselirken, HDL seviyesinde kontrol grubuna göre anlamlı bir azalma görülmüştür. Gruplar arasında OxLDL ve TAS değerleri bakımından anlamlı bir fark olduğu tespit edilmiştir.
Sonuç: Bu çalışmada deneysel obez sıçan modellerinde Silibinin, serum LDL, TK, VLDL, HDL, TG, OxLDL düzeylerine etkisi incelenmiştir. Silibinin, yüksek kolesterol diyetle beslenen (YKD) sıçanlarda 100 mg/kg dozda kullanıldığında, TG ve LDL seviyelerini düşürmede, HDL seviyesini arttırmada ve hepatik lipid birikimini azaltmada etkili bir rol oynadığı sonucuna ulaşılmıştır. Silibin kullanımının, antihiperlipidemik etkiye yol açmadığı, ancak antioksidan etkiye neden olduğu ortaya konulmuştur.

Keywords

Silibinin, Hyperlipidemia, Antioxidant, Atherosclerosis

Supporting Institution

Hatay Mustafa Kemal Üniversitesi Bilimsel Araştırma Projeleri Birimi

Project Number

18.YL.023

Effect of silibinin on the hyperlipidemia in rats fed with high cholesterol diet

Abstract

Purpose: Despite current hypolipidemic drugs, the search for a more effective hypolipidemic agent is ongoing. In this study, it was aimed to investigate the effect of Silibinin on hyperlipidemia in rats fed high cholesterol diet (HCD).
Materials and Methods: Rats were made obese. Rats were given egg yolk for 60 days and then 50 mg/kg, 100 mg/kg Silibinin were applied i.p. for 7 days.
Results: The first and last weights of the rats were significantly different. While total cholesterol (TC), LDL, TG and VLDL levels increased significantly in the groups fed with HCD, HDL level reduced compared to control group (CG). OxLDL and TAS were significantly different between groups.
Conclusion: The effects of Silibinin on serum LDL, TC, VLDL, HDL, TG, OxLDL levels and to observe the antioxidant effect, TAS and TOS were investigated in experimental obese rat models. It was concluded that Silibinin plays an effective role in lowering TG and LDL levels, increasing HDL levels and decreasing hepatic lipid accumulation in HCD rats at 100 mg/kg dose. The use of Silibinin does not cause antihyperlipidemic effect but has antioxidant effect.

Project Number

18.YL.023

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