İkiz prematüre bebek olmak sistemik inflamatuvar indeksleri nasıl etkiler?

Year 2024, Volume: 49 Issue: 3, 646 - 654, 30.09.2024

Ufuk Çakır , Cüneyt Tayman

https://doi.org/10.17826/cumj.1460277

Abstract

Amaç: Sistemik inflamatuar indeksler neonatoloji alanında hastalıklarda yeni tanımlanan parametrelerdir. Ancak ikiz prematürelerde sistemik inflamatuar indeks düzeylerinin değişip değişmediği bilinmemektedir.
Gereç ve Yöntem: Çalışmamıza gebelik yaşı <32 hafta olan prematüre bebekler dahil edildi. Tüm hastaların demografik özellikleri, morbidite, mortalite, lökosit, nötrofil, monosit, lenfosit, trombosit sayı verileri geriye dönük olarak kaydedildi. Nötrofil-lenfosit oranı (NLR), trombosit-lenfosit oranı (PLR), monosit-lenfosit oranı (MLR), sistemik immün inflamasyon indeksi (SII), pan-immün-inflamasyon değeri (PIV) ve sistemik inflamasyon yanıt indeksi (SIRI) değerleri hesaplandı. İkiz ve tekil bebekler demografik özellikler, morbidite, mortalite, tam kan sayımı parametreleri ve sistemik inflamatuar indeksler açısından birbirleriyle karşılaştırıldı.
Bulgular: Çalışmaya 200'ü ikiz, 753'ü tekil prematüre olmak üzere toplam 953 bebek dahil edildi. İkiz grupta sezaryen doğum, solunum sıkıntısı sendromu ve intraventriküler kanama tekil gruba göre daha yüksek bulundu. İkiz grupta lökosit, nötrofil, monosit, lenfosit sayısı daha düşük, trombosit sayısı ise tekil grupta anlamlı olarak yüksek bulundu. İkiz grupta tekil gruba göre PLR değeri (sırasıyla, 41,81 ve 32,09) daha yüksek, PIV değeri (sırasıyla, 43,66 ve 47,93) daha düşüktü. NLR, MLR, SII, SIRI değerleri ikiz ve tekil gruplar arasında benzerdi. Birinci ve ikinci ikiz prematüre bebeklerin demografik özellikleri, morbidite, mortalite, tam kan sayımı parametreleri ve sistemik inflamatuar indeksleri açısından farklılık yoktu.
Sonuç: İkizler ve tekiz prematüre bebekler arasındaki sistemik inflamatuar indeksler ve çoklu hematolojik parametrelerdeki farklılıklar klinik sonuçları anlamak için pre/postnatal koşullar değerlendirilerek dikkatle yorumlanmalıdır.

Keywords

Sistemik inflamatuar indeksler, Yenidoğan, Prematüre, Tekil, İkiz

Ethical Statement

Çalışmaya başlamadan önce yerel etik kuruldan etik onay alındı.

Supporting Institution

yok

Thanks

yok

How does being a twin premature infant affect systemic inflammatory indices?

Abstract

Purpose: Systemic inflammatory indices are newly defined parameters in diseases in the field of neonatology. However, it is not known whether the levels of systemic inflammatory indices change in twin preterms.
Materials and Methods: Premature infants <32 weeks of gestational age were included in our study. Demographic characteristics, morbidity, mortality, leukocyte, neutrophil, monocyte, lymphocyte, platelet count data of all patients were recorded retrospectively. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune ratio-inflammation index (SII), pan-immune-inflammation value (PIV) and systemic inflammation response index (SIRI) values were calculated. Twins and singleton infants were compared with each other in terms of demographic characteristics, morbidity, mortality, complete blood count parameters and systemic inflammatory indices.
Results: A total of 953 infants, including 200 twins and 753 singleton premature infants, were included in the study. Cesarean section, respiratory distress syndrome, and intraventricular hemorrhage were found to be higher in the twins group compared to the singleton group. The leukocyte, neutrophil, monocyte, lymphocyte count was found to be lower in the twins group and the platelet count was found to be significantly higher in the singleton group. PLR value was higher (41.81 and 32.09, respectively) and PIV value was lower (43.66 and 47.93, respectively) in the twins group compared to the singleton group. NLR, MLR, SII, SIRI values were similar between twins and singleton groups. There was no difference in demographic characteristics, morbidity, mortality, complete blood count parameters and systemic inflammatory indices of the first and the second twin premature infants.
Conclusion: Differences in systemic inflammatory indices and multiple hematological parameters between twins and singleton premature infants should be interpreted carefully taking into account pre/postnatal conditions to understand clinical outcomes.

Keywords

Systemic inflammatory indices, Infant, Premature, Singleton, Twin

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