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Year 2018, Volume: 1 Issue: 2, 117 - 119, 31.12.2018
https://doi.org/10.38093/cupmap.480122

Abstract

References

  • 1. Republic Turkey Ministry of Health. Turkish Medicines And Medical Devices Agency Cosmetic Law, 2005, No, 25823.
  • 2. ISO 22716, Cosmetics - Good Manufacturing Practices (GMP) - Guidelines on Good Manufacturing Practices, 2013.
  • 3. ISO 17516, Cosmetic microbiology microbiological limits, 2014.
  • 4. European Pharmacopoeia 9.0, 2.6.12. Microbiological exaimination of non-sterile products: microbial enumeration tests, 2017.
  • 5. ISO 21149, Cosmetic microbiology enumeration and detection of aerobic mesophilic bacteria, 2006.

Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products

Year 2018, Volume: 1 Issue: 2, 117 - 119, 31.12.2018
https://doi.org/10.38093/cupmap.480122

Abstract

Blue and green cosmetics are sensitive products for
microbial contamination and reducing the contamination producing according to
Cosmetic Good Manufacturing Practice (ISO 22716), providing proper storage
condition and packaging  are effective
factors. In addition antimicrobial effective preservatives can be added to
protect the cosmetic products.1,2 Generally, preservatives are
chemical substrates that are effective on cytoplasm (conjugation mechanism,
ribosomes, nucleic acids, thiol groups, amino groups), cell wall and cytoplasm
membrane (membrane potential, enzymes, membrane penetration).3 The
neutralization of the antimicrobial effect of the preservatives in
microbiological quality control of cosmetics is essential for the safety of the
tests. The antimicrobial preservative in the cosmetic which is transferred to
the medium affects the test negatively. The neutralization process can be
carried out according to international standards used in microbiological
analysis of cosmetic products. The neutralization of preservatives in cosmetics
can be performed by adding of neutralizing agents in solvent, medium and/or
washing solution. The agents which are reacted with the preservative groups for
the removal of antimicrobial affect are used for this neutralization process
which is necessary for the removal of antimicrobial effect. According to
European Pharmacopeia 2.6.12. sodium bisulfite for glutaraldehyde and mercury
compounds; dilution for sorbates and aldehydes; lecithin, polysorbate 80,
saponin for quaternary ammonium compounds, parabens and iodines; thioglycollate
for mercurial; thiosulfate for halogens can be used as neutralizing agents.4
Lecithin, polysorbate 80 for parabens, phenoxyethanol, phenylethanol; Lecithin,
saponin, polysorbate 80, sodium dodecyl sulphate for quaternary ammonium
compounds and cationic surfactants; glycine, histidine for aldehydes
formaldehyde
-release agents; sodium thiosulphate for oxidizing
agents; sodium bisulphate, L-cysteine and thioglycollic acid for metallic salts
can be added to the medium, solvent and/or washing solutions according to ISO
21149.5 For the removal of antimicrobial effect, neutralizing agents
in proper concentrations should be added to medium, solvents and washing
solutions. The addition of these agents with antimicrobial effect should be
proved by the studies of conformity. Neutralizing agents react with antimicrobial
agents to eliminate the antimicrobial effect.

References

  • 1. Republic Turkey Ministry of Health. Turkish Medicines And Medical Devices Agency Cosmetic Law, 2005, No, 25823.
  • 2. ISO 22716, Cosmetics - Good Manufacturing Practices (GMP) - Guidelines on Good Manufacturing Practices, 2013.
  • 3. ISO 17516, Cosmetic microbiology microbiological limits, 2014.
  • 4. European Pharmacopoeia 9.0, 2.6.12. Microbiological exaimination of non-sterile products: microbial enumeration tests, 2017.
  • 5. ISO 21149, Cosmetic microbiology enumeration and detection of aerobic mesophilic bacteria, 2006.
There are 5 citations in total.

Details

Primary Language English
Journal Section Research Articles
Authors

Gökhan Cengiz This is me 0000-0002-8275-8549

Evren Algın Yapar 0000-0002-6504-4608

Publication Date December 31, 2018
Published in Issue Year 2018 Volume: 1 Issue: 2

Cite

APA Cengiz, G., & Algın Yapar, E. (2018). Neutalizants for Antimicrobial Effective Preservatives in Microbiological Analysis in Cosmetic Products. Current Perspectives on Medicinal and Aromatic Plants, 1(2), 117-119. https://doi.org/10.38093/cupmap.480122

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