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FRONTAL QRS-T ANGLE AS A MARKER OF LEFT VENTRICULAR HYPERTROPHY IN PATIENTS WITH ESSENTIAL HYPERTENSION

Year 2018, Volume: 32 Issue: 2, 77 - 87, 27.08.2018
https://doi.org/10.5505/deutfd.2018.98700

Abstract

Objective: Previous studies showed that myocardial
repolarization markers are prolonged in hypertensive patients with left
ventricular hypertrophy (LVH) compared to patients with non-LVH. Frontal QRS-T
angle, angle between the QRS and T wave axes, is novel marker of myocardial
repolarization. The aim of our study is to investigate the relationship between
frontal QRS-T angle and LVH in hypertensive patients.





Material and Method: A total 187 hypertensive
patients were included our study. Frontal QRS-T angle was obtained from the
automatic reports of the ECG machine. LVH was defined as left ventricular
mass index (LVMI) > 115 g/m2 in men and 95 g/m2 in
women.


Results: Patients with LVH had significantly longer QT
dispersion (p=0.028), corrected QT dispersion (p=0.010), Tp-e interval (p =
0.045) and wider frontal QRS-T angle (p<0.001) compared to patients with
non-LVH. In correlation analysis, LVMI was positively correlated with QT
dispersion (r=0.150, p=0.041), corrected QT dispersion (r=0.167, p=0.022),
Tp-e interval (r = 0.160, p = 0.046) and frontal QRS-T angle (r=0.360,
p<0.001). By a multivariate analysis, frontal QRS-T (OR: 1.04, 95% CI:
1.02-1.06, P < 0.001) angle was found to be the only independent predictor
of LVH. ROC curve analysis showed that the best cut-off value of frontal
QRS-T angle for predicting LVH was ≥ 28o. This cut-off value
predicted LVH with a sensitivity of 70.5% and a specificity of 54.5%.


Conclusion: Frontal QRS-T angle is a simple,
inexpensive and easily obtainable parameter from surface electrocardiography.
It can be used as a simple marker of LVH in hypertensive subjects. 


References

  • Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013;34:2159-2219.
  • Messerli FH, Williams B, Ritz E. Essential hypertension. Lancet 2007;370:591-603.
  • Tin LL, Beevers DG, Lip GY. Hypertension, left ventricular hypertrophy, and sudden death. Curr Cardiol Rep 2002;4:449-457.
  • Casale PN, Devereux RB, Milner M, et al. Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men. Ann Intern Med 1986;105:173-178.
  • Rossi MA. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens 1998;16:1031–1041.
  • Berk BC, Fujiwara K, Lehoux S. ECM remodeling in hypertensive heart disease. J Clin Invest 2007;117:568–575.
  • Perkiömäki JS, Ikäheimo MJ, Pikkujämsä SM, et al. Dispersion of the QT interval and autonomic modulation of heart rate in hypertensive men with and without left ventricular hypertrophy. Hypertension 1996;28:16-21.
  • Zareba W, Moss AJ, le Cessie S. Dispersion of ventricular repolarization and arrhythmic cardiac death in coronary artery disease. Am J Cardiol 1994;74:550-553.
  • Clarkson PB, Naas AA, McMahon A, MacLeod C, Struthers AD, MacDonald TM. QT dispersion in essential hypertension. QJM 1995;88:327–332.
  • Mayet J, Shahi M, McGrath K, et al. Left ventricular hypertrophy and QT dispersion in hypertension. Hypertension 1996;28:791-796.
  • Zhao Z, Yuan Z, Ji Y, Wu Y, Qi Y. Left ventricular hypertrophy amplifies the QT, and Tp-e intervals and the Tp-e/ QT ratio of left chest ECG. J Biomed Res. 2010;24:69-72.
  • Ale OK, Ajuluchukwu JN, Oke DA, Mbakwem AC. QT dispersion in hypertensive Nigerians with and without left ventricular hypertrophy. West Afr J Med 2013;32:57-61.
  • Oehler A, Feldman T, Henrikson CA, Tereshchenko LG. QRS-T angle: a review. Ann Noninvasive Electrocardiol 2014;19:534-542.
  • Ishizawa K. Mean QRS, ventricular gradient and left ventricular mass in patients with eccentric left ventricular hypertrophy. J Electrocardiol 1975;8:227–232.
  • Ishizawa K, Ishizawa K, Motomura M, Konishi T, Wakabayashi A. High reliability rates of spatial pattern analysis by vectorcardiogram in assessing the severity of eccentric left ventricular hypertrophy. Am Heart J 1976;91:50–57.
  • Okin PM. Electrocardiography in women: taking the initiative. Circulation 2006; 113:464–466.
  • Zhang ZM, Prineas RJ, Case D, Soliman EZ, Rautaharju PM; ARIC Research Group. Comparison of the prognostic significance of the electrocardiographic QRS/T angles in predicting incident coronary heart disease and total mortality (from the atherosclerosis risk in communities study). Am J Cardiol 2007;100:844–849.
  • Perkiömäki J, Koistinen MJ, Yli-Mäyry S, Huikuri H. Dispersion of the QT interval in patients with and without susceptibility to ventricular tachyarrhythmias after previous myocardial infarction. J Am Coll Cardiol 1995;26:174-179.
  • Bazett HC. An analysis of the time relations of electrocardiograms. Heart 1920;7:353–370.
  • Castro Hevia J, Antzelevitch C, Tornés Bárzaga F, et al. Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome. J Am Coll Cardiol 2006;47:1828-1834.
  • Panikkath R, Reinier K, Uy-Evanado A, et al. Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. Circ Arrhythm Electrophysiol 2011;4:441-447.
  • Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358-367.
  • Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings. Am J Cardiol 1986;57:450-458.
  • Aro AL, Huikuri HV, Tikkanen JT, et al. QRS-T angle as a predictor of sudden cardiac death in a middle-aged general population. Europace 2012;14:872–876
  • Katholi RE, Couri DM. Left ventricular hypertrophy: major risk factor in patients with hypertension: update and practical clinical applications. Int J Hypertens 2011;2011:495349.
  • Pye MP, Cobbe SM. Mechanisms of ventricular arrhythmias in cardiac failure and hypertrophy. Cardiovasc Res 1992;26:740-750.
  • Raposeiras-Roubín S, Virgós-Lamela A, Bouzas-Cruz N, et al. Usefulness of the QRS-T angle to improve long-term risk stratification of patients with acute myocardial infarction and depressed left ventricular ejection fraction. Am J Cardiol 2014;113:1312-1319.
  • Macfarlane PW. The frontal plane QRS-T angle. Europace. 2012;14:773-775.

Esansiyel Hipertansiyonlu Hastalarda Sol Ventrikül Hipertrofisinin Bir Göstergesi Olarak Frontal QRS-T Açısı

Year 2018, Volume: 32 Issue: 2, 77 - 87, 27.08.2018
https://doi.org/10.5505/deutfd.2018.98700

Abstract

Amaç: Önceki çalışmalarda sol ventrikül
hipertrofisi (SVH) bulunan hipertansif hastalarda, SVH bulunmayan hastalara
göre miyokardiyal repolarizasyon belirteçlerinin uzamış olduğu gösterilmiştir.
Ortalama QRS ve T dalgası eksenleri arasındaki açı olarak tanımlanan frontal
QRS-T açısı da miyokard repolarizasyonunun yeni bir göstergesidir. Çalışmamızın
amacı, hipertansif hastalarda frontal QRS-T açısı ile SVH arasındaki ilişkiyi
incelemektir.



Gereç ve Yöntem: Çalışmamıza toplam
187 hipertansif hasta dâhil edildi. Frontal QRS-T açısı, EKG cihazının otomatik
raporlarından elde edildi. Sol ventrikül kitle indeksinin (SVKİ) erkeklerde
> 115 g/m2, kadınlarda > 95 g/m2 olması SVH olarak
tanımlandı.



Bulgular: SVH bulunan
hastalarda, SVH bulunmayan hastalara göre QT dispersiyonu (p = 0,028),
düzeltilmiş QT dispersiyonu  (p = 0,010)
ve Tp-e aralığı (p = 0,045) daha uzun, frontal QRS-T açısı (p < 0,001) ise
daha genişti. Korelasyon analizinde, SVKİ QT dispersiyonu (r= 0,150, p= 0,041),
düzeltilmiş QT dispersiyonu (r= 0,167, p= 0,022), Tp-e aralığı (r= 0,160, p= 0,046)  ve frontal QRS-T açısı (r= 0,360, p < 0,001)
ile pozitif bir şekilde korele idi. Çok değişkenli analizle, frontal QRS-T
açısı SVH'nin tek bağımsız prediktörü olarak bulundu (OR: 1,04, 95% CI: 1,02-1,06,
p < 0,001). ROC curve analizinde frontal QRS-T açısının SVH'yi göstermedeki
en iyi kesme değeri 28o idi. Bu kesme değer, SVH'yi %70,5
sensitivite ve %54,5 spesifite ile öngördü.



Sonuç: Frontal QRS-T açısı, basit, ucuz ve
12 derivasyonlu yüzey elektrokardiyografiden kolaylıkla elde edilebilen bir
parametredir. Bu açı, hipertansif hastalarda SVH'nin basit bir göstergesi
olarak kullanılabilir.

References

  • Mancia G, Fagard R, Narkiewicz K, et al. 2013 ESH/ESC Guidelines for the management of hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 2013;34:2159-2219.
  • Messerli FH, Williams B, Ritz E. Essential hypertension. Lancet 2007;370:591-603.
  • Tin LL, Beevers DG, Lip GY. Hypertension, left ventricular hypertrophy, and sudden death. Curr Cardiol Rep 2002;4:449-457.
  • Casale PN, Devereux RB, Milner M, et al. Value of echocardiographic measurement of left ventricular mass in predicting cardiovascular morbid events in hypertensive men. Ann Intern Med 1986;105:173-178.
  • Rossi MA. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens 1998;16:1031–1041.
  • Berk BC, Fujiwara K, Lehoux S. ECM remodeling in hypertensive heart disease. J Clin Invest 2007;117:568–575.
  • Perkiömäki JS, Ikäheimo MJ, Pikkujämsä SM, et al. Dispersion of the QT interval and autonomic modulation of heart rate in hypertensive men with and without left ventricular hypertrophy. Hypertension 1996;28:16-21.
  • Zareba W, Moss AJ, le Cessie S. Dispersion of ventricular repolarization and arrhythmic cardiac death in coronary artery disease. Am J Cardiol 1994;74:550-553.
  • Clarkson PB, Naas AA, McMahon A, MacLeod C, Struthers AD, MacDonald TM. QT dispersion in essential hypertension. QJM 1995;88:327–332.
  • Mayet J, Shahi M, McGrath K, et al. Left ventricular hypertrophy and QT dispersion in hypertension. Hypertension 1996;28:791-796.
  • Zhao Z, Yuan Z, Ji Y, Wu Y, Qi Y. Left ventricular hypertrophy amplifies the QT, and Tp-e intervals and the Tp-e/ QT ratio of left chest ECG. J Biomed Res. 2010;24:69-72.
  • Ale OK, Ajuluchukwu JN, Oke DA, Mbakwem AC. QT dispersion in hypertensive Nigerians with and without left ventricular hypertrophy. West Afr J Med 2013;32:57-61.
  • Oehler A, Feldman T, Henrikson CA, Tereshchenko LG. QRS-T angle: a review. Ann Noninvasive Electrocardiol 2014;19:534-542.
  • Ishizawa K. Mean QRS, ventricular gradient and left ventricular mass in patients with eccentric left ventricular hypertrophy. J Electrocardiol 1975;8:227–232.
  • Ishizawa K, Ishizawa K, Motomura M, Konishi T, Wakabayashi A. High reliability rates of spatial pattern analysis by vectorcardiogram in assessing the severity of eccentric left ventricular hypertrophy. Am Heart J 1976;91:50–57.
  • Okin PM. Electrocardiography in women: taking the initiative. Circulation 2006; 113:464–466.
  • Zhang ZM, Prineas RJ, Case D, Soliman EZ, Rautaharju PM; ARIC Research Group. Comparison of the prognostic significance of the electrocardiographic QRS/T angles in predicting incident coronary heart disease and total mortality (from the atherosclerosis risk in communities study). Am J Cardiol 2007;100:844–849.
  • Perkiömäki J, Koistinen MJ, Yli-Mäyry S, Huikuri H. Dispersion of the QT interval in patients with and without susceptibility to ventricular tachyarrhythmias after previous myocardial infarction. J Am Coll Cardiol 1995;26:174-179.
  • Bazett HC. An analysis of the time relations of electrocardiograms. Heart 1920;7:353–370.
  • Castro Hevia J, Antzelevitch C, Tornés Bárzaga F, et al. Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome. J Am Coll Cardiol 2006;47:1828-1834.
  • Panikkath R, Reinier K, Uy-Evanado A, et al. Prolonged Tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. Circ Arrhythm Electrophysiol 2011;4:441-447.
  • Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr 1989;2:358-367.
  • Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings. Am J Cardiol 1986;57:450-458.
  • Aro AL, Huikuri HV, Tikkanen JT, et al. QRS-T angle as a predictor of sudden cardiac death in a middle-aged general population. Europace 2012;14:872–876
  • Katholi RE, Couri DM. Left ventricular hypertrophy: major risk factor in patients with hypertension: update and practical clinical applications. Int J Hypertens 2011;2011:495349.
  • Pye MP, Cobbe SM. Mechanisms of ventricular arrhythmias in cardiac failure and hypertrophy. Cardiovasc Res 1992;26:740-750.
  • Raposeiras-Roubín S, Virgós-Lamela A, Bouzas-Cruz N, et al. Usefulness of the QRS-T angle to improve long-term risk stratification of patients with acute myocardial infarction and depressed left ventricular ejection fraction. Am J Cardiol 2014;113:1312-1319.
  • Macfarlane PW. The frontal plane QRS-T angle. Europace. 2012;14:773-775.
There are 28 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Zülkif Tanrıverdi 0000-0002-1053-1417

Feyzullah Beşli This is me

Fatih Güngören This is me

İbrahim Halil Altıparmak This is me

Asuman Biçer Yeşilay This is me

Musluhittin Emre Erkuş This is me

Recep Demirbağ This is me

Publication Date August 27, 2018
Submission Date December 31, 2017
Published in Issue Year 2018 Volume: 32 Issue: 2

Cite

Vancouver Tanrıverdi Z, Beşli F, Güngören F, Altıparmak İH, Biçer Yeşilay A, Erkuş ME, Demirbağ R. Esansiyel Hipertansiyonlu Hastalarda Sol Ventrikül Hipertrofisinin Bir Göstergesi Olarak Frontal QRS-T Açısı. DEU Tıp Derg. 2018;32(2):77-8.