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            <front>

                <journal-meta>
                                    <journal-id></journal-id>
            <journal-title-group>
                                                                                    <journal-title>Dicle Medical Journal</journal-title>
            </journal-title-group>
                            <issn pub-type="ppub">1300-2945</issn>
                                        <issn pub-type="epub">1308-9889</issn>
                                                                                            <publisher>
                    <publisher-name>Dicle University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.5798/dicletip.1906358</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Health Care Administration</subject>
                                                            <subject>Medical Education</subject>
                                                            <subject>Health Services and Systems (Other)</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Sağlık Kurumları Yönetimi</subject>
                                                            <subject>Tıp Eğitimi</subject>
                                                            <subject>Sağlık Hizmetleri ve Sistemleri (Diğer)</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <article-title>Epidemiological Evaluation of Patients with Primary Glomerulonephritis in the Southeastern Anatolia Region</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="tr">
                                    <trans-title>Güneydoğu Anadolu Bölgesinde Primer Glomerülonefritli Hastaların Epidemiyolojik Değerlendirilmesi</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                <name>
                                    <surname>Öngören</surname>
                                    <given-names>Ziya</given-names>
                                </name>
                                                                    <aff>DICLE UNIVERSITY</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Sevim</surname>
                                    <given-names>Muhammed Emre</given-names>
                                </name>
                                                                    <aff>Dicle University</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Aydın</surname>
                                    <given-names>Emre</given-names>
                                </name>
                                                                    <aff>Dicle University</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Yılmaz Aydın</surname>
                                    <given-names>Fatma</given-names>
                                </name>
                                                                    <aff>Dicle University</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Yildirim</surname>
                                    <given-names>Yasar</given-names>
                                </name>
                                                                    <aff>Dicle University</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Alabalık</surname>
                                    <given-names>Ulas</given-names>
                                </name>
                                                                    <aff>Dicle University</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Eynel</surname>
                                    <given-names>Eren</given-names>
                                </name>
                                                                    <aff>Dicle University</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                <name>
                                    <surname>Yılmaz</surname>
                                    <given-names>Zülfikar</given-names>
                                </name>
                                                                    <aff>Dicle University</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20260310">
                    <day>03</day>
                    <month>10</month>
                    <year>2026</year>
                </pub-date>
                                        <volume>53</volume>
                                        <issue>1</issue>
                                        <fpage>1</fpage>
                                        <lpage>7</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20250808">
                        <day>08</day>
                        <month>08</month>
                        <year>2025</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20251229">
                        <day>12</day>
                        <month>29</month>
                        <year>2025</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2003, Dicle Medical Journal</copyright-statement>
                    <copyright-year>2003</copyright-year>
                    <copyright-holder>Dicle Medical Journal</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>Objective: The aim of this study was to provide information on the demographic characteristics and laboratory parameters of primary glomerulonephritis (PGN) patients diagnosed at our center and to determine the epidemiology of PGN in our region.Method: 148 adult PGN cases diagnosed via percutaneous renal biopsy at our hospital were included in the study. Patients whose biopsy specimens could not be analyzed with immunofluorescence, those reported as non-diagnostic, those with a history of kidney transplantation who underwent biopsy, those who underwent biopsy with a presumptive diagnosis of malignancy, and those whose tests were unavailable were excluded from the study.Results: The overall mean age of the patients was 38.5±12.9 years. 50% of the patients were female and 50% were male. Our study found that biopsies were performed for nephrotic syndrome (70.3%), asymptomatic urinary abnormalities (21.6%), and acute nephritic syndrome (8.1%) in both genders and all age groups. The most common PGN subtypes were FSGS (41.2%) and MGN (18.9%), respectively. Following these, the following were IgAN (15.5%), MPGN (14.2%), RPGN (5.4%), and MCD (4.7%). FSGS was the most common PGN subtype in patients younger than 60 years of age, and MGN in patients older than 60 years. MGN was found to be the PGN subtype with the highest mean proteinuria.Conclusion: This is the first study to investigate the distribution, demographic characteristics, and laboratory parameters of primary glomerulonephritis in the Southeastern Anatolia Region and provides information about the PGN epidemiology in our region. The data obtained in our study were consistent with many studies conducted in our country and around the world.</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="tr">
                            <p>Amaç: Bu çalışmanın amacı; merkezimizde tanı alan primer glomerülonefrit (PGN) olgularının demografik özellikleri ve laboratuvar parametreleri hakkında bilgi sağlamak ve bölgemizdeki PGN epidemiyolojisini belirlemektir.Yöntemler: Çalışmaya hastanemizde perkütan böbrek biyopsisi ile tanı konulan 148 erişkin PGN olgusu dahil edildi. Biyopsi örneğinden immünfloresan inceleme yapılamayan hastalar, non diagnositik olarak raporlanan hastalar, böbrek nakli öyküsü olup biyopsi yapılan hastalar, malignite ön tanısıyla biyopsi yapılan hastalar ve tetkiklerine ulaşılamayan hastalar çalışmaya alınmadı.Bulgular: Hastaların genel yaş ortalaması 38.5±12.9 yıl olarak saptandı. Hastaların %50’si kadın, %50’si erkekti. Çalışmamızda biyopsilerin hem her iki cinsiyette hem de tüm yaş gruplarında sırasıyla nefrotik sendrom (%70,3), asemptomatik üriner anormallikler (%21,6) ve akut nefritik sendrom (%8,1) endikasyonlarıyla yapıldığı saptandı. En sık görülen PGN alt tipleri sırasıyla FSGS (%41,2) ve MGN (%18,9) olarak saptandı. Bunlardan sonra diğer tanıların sıklık sırası IgAN (%15,5), MPGN (%14,2), RPGN (%5,4) ve MDH (%4,7) şeklinde saptandı. En sık görülen PGN alt tipinin 60 yaşından küçük hastalarda FSGS, 60 yaşından büyük hastalarda ise MGN olduğu saptandı. En yüksek proteinüri ortalamasına sahip PGN alt tipinin MGN olduğu görüldü.Sonuç: Çalışmamız, Güneydoğu Anadolu Bölgesinde primer glomerülonefritlerin dağılımları, demografik özellikleri ve laboratuvar parametreleri hakkında yapılan ilk çalışma olup bölgemizin PGN epidemiyolojisi hakkında bilgi sağlamaktadır. Çalışmamızda elde ettiğimiz veriler ülkemizde ve dünyada yapılan birçok çalışmayla uyumlu bulundu.</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>primary glomerulonephritis</kwd>
                                                    <kwd>  nephrotic syndrome</kwd>
                                                    <kwd>  acute nephritic syndrome</kwd>
                                                    <kwd>  epidemiology</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="tr">
                                                    <kwd>primer glomerülonefritler</kwd>
                                                    <kwd>  nefrotik sendrom</kwd>
                                                    <kwd>  akut nefritik sendrom</kwd>
                                                    <kwd>  epidemiyoloji.</kwd>
                                            </kwd-group>
                                                                                                            </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">1.Süleymanlar G, Ateş K, Seyahi N. Türkiye&#039;deNefroloji, Diyaliz ve Transplantasyon. Türk NefrolojiDerneği Yayınları 2019;13.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">2.Woo KT, Chan CM, Lim C, et al. A GlobalEvolutionary Trend of the Frequency of Primary Glomerulonephritis over the Past Four Decades. Kidney Dis (Basel)2019 Oct;5(4):247-258.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">3.Sim JJ, Batech M, Hever A, et al. Distribution ofBiopsy-Proven Presumed Primary Glomerulonephropathies in 2000-2011 Among aRacially and Ethnically Diverse US Population. Am JKidney Dis 2016 Oct;68(4):533-544.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">4.Zink CM, Ernst S, Riehl J, et al. Trends of renaldiseases in Germany: review of a regional renalbiopsy database from 1990 to 2013. Clin Kidney J.2019 Dec; 12(6): 795–800.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">5.Türkmen A, Şumnu A, Cebeci E, et al.Epidemiological features of primary glomerulardisease in Turkey: a multicenter study by theTurkish Society of Nephrology Glomerular DiseasesWorking Group. BMC Nephrol. 2020 Nov14;21(1):481.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">6.Gesualdo L, Di Palma AM, Morrone LF, et al. Italianimmunopathology group ISoN. The Italianexperience of the national registry of renal biopsies.Kidney Int. 2004;66(3):890–894.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">7.Malafronte P, Mastroianni-Kirsztajn G, BetônicoGN, et al. Paulista registry of glomerulonephritis: 5-year data report. Nephrol Dialysis Transplantation.2006;21(11):3098–3105.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">8.Özdemir E. Fırat Üniversitesi HastanesindePerkütan Böbrek Biyopsisi Yapılan HastalarınRetrospektif İncelenmesi. Tıpta Uzmanlık Tezi 2017.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">9.Nasar Yousuf Alwahaibi NY, Issaei HK, Dhahli BS.Spectrum of glomerular diseases in Arab countries:A systematic review. Saudi J Kidney Dis Transpl.Nov-Dec 2018;29(6):1256-1266.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">10.Yim T, Kim S, Park S, et al. Patterns in renaldiseases diagnosed by kidney biopsy: A single-center experience. Kidney Research and ClinicalPractice 2020 Mar; 39(1): 60-69.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">11.Hou J-H, Zhu H-X, Zhou M-L, et al. Changes in theSpectrum of kidney diseases: an analysis of 40,759biopsy-proven cases from 2003 to 2014 in China.Kidney Dis. 2018;4(1):10–9.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">12.Ozturk S, Sumnu A, Seyahi N, et al. Demographicand clinical characteristics of primary glomerulardiseases in Turkey. Int Urol Nephrol. 2014Dec;46(12):2347- 55.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">13.Koç L. 2002-2010 Yılları Arasında FarabiHastanesi’nde Erişkin Hastalarda Uygulanmış OlanBöbrek Biyopsilerinde GözlenenGlomerulonefritlerin Dağılımı. Tıpta Uzmanlık Tezi2012.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
