BibTex RIS Cite

Chronic Discogenic Low Back Pain and Non-Surgical Treatment Methods: An Update

Year 2016, Volume: 43 Issue: 1, 181 - 191, 01.03.2016

Abstract

Low back pain originating from intervertebral disc is described by two separate but related etiologies: disc herniation and discogenic pain. When other causes are excluded, prevalence of discogenic pain was reported to be between 17-42%. Diagnostic modalities include clinical examination, imaging, and discography and provocative discography remains to be the golden standard for diagnosis. Treatment methods include noninvasive approaches such as drugs, physiotherapy modalities, and multidisciplinary biopsychosocial rehabilitation; invasive approaches such as intradiscal treatments and epidural injections; and lastly surgical approaches such as fusion and artificial joint replacement. Evidence for drug treatment in chronic discogenic low back pain is limited to nonsteroidal anti-inflammatory drugs and opioids which are associated with many adverse outcomes. It has been shown that when noninvasive methods are used together with other modalities patients may obtain additional benefits. Evidence base is limited for many other physical and behavioral treatment methods like low back school and specific exercise programs. There is moderate evidence for epidural injections and poor evidence for intradiscal treatments. Evidence for surgical fusions and disc replacements are similar and it is not superior to multidisciplinary biopsychosocial rehabilitation or well-designed physical treatment. Multiple authorities have emphasized potential complications and limited the indication of surgical approaches to patients who do not response conservative treatments. In future, the most promising treatments seem to be multidisciplinary and long-term exercise programs and/or epidural injections. High quality randomized controlled studies with adequate sample sizes and long term follow ups should be designed in order to determine optimal treatment modalities.
Key words: discogenic low back pain, non-surgical treatment, updates

References

  • Deyo RA, Weinstein JN. Low back pain. N Engl J Med. 2001;344:363-370.
  • DePalma MJ, Ketchum JM, Saullo T. What is the source of chronic low back pain and does age play a role? Pain Med 2011;12:224-233.
  • Schwarzer AC, Aprill CN, Derby R, et al. The prevalence and clinical features of internal disc disruption in patients with chronic low back pain. Spine 1995;20:1878-1883.
  • Schwarzer AC, Aprill CN, Derby R, et al. The relative contributions
  • of the disc and zygapophyseal joint in chronic low back pain. Spine 1994;19:801-806.
  • Yakut F, Özlü MM, Taşdemir N. Kauda ekuinanın redundant sinir kökü sendromunun magnetik rezonans görüntüleme bulguları. Dicle Med J 2012;39:213-216.
  • Menkü A, Kamaşak K, Göçmez C, et al. Travmanın eşlik etmediği
  • akut monopleji nedeni olan intradural servikal disk hernisi: Olgu sunumu. J Clin Exp Invest 2014;5:112-114.
  • Köksal V, Şen A, Erdivanlı B, Özdemir B. Spinal anestezi altında yapılan lomber disk cerrahilerinin retrospektif değerlendirmesi. J Clin Exp Invest 2014;5:54-58.
  • Vernon-Roberts B, Moore RJ, Fraser RD. The natural history of age-related disc degeneration: the pathology and sequelae of tears. Spine 2007;32:2797-2804.
  • Peng B, Fu X, Pang X, et al. Prospective clinical study on natural history of discogenic low back pain at 4 years of follow-up. Pain Physician 2012;15:525-532.
  • Hurri H, Karppinen J. Discogenic pain. Pain 2004;112:225-228.
  • Peng B, Wu W, Hou S, et al. The pathogenesis of discogenic low back pain. J Bone Joint Surg Br 2005;87:62-67.
  • Vernon-Roberts B, Moore RJ, Fraser RD. The natural history of age-related disc degeneration: the influence of age and pathology on cell populations in the L4–L5 disc. Spine 2008;33:2767-2673.
  • Peng BG. Pathophysiology, diagnosis, and treatment of iscogenic
  • low back pain. World J Orthop 2013;4:42.
  • Manchikanti L, Abdi S, Atluri S, et al. An update of omprehensive
  • evidence-based guidelines for interventional techniques in chronic spinal pain. Part II: guidance and recommendations. Pain Physician 2013;16:49-283.
  • Bogduk N, Aprill C, Derby R. Lumbar Discogenic Pain:State-of-the-Art Review. Pain Med 2013;14:813-836.
  • Malik KM, Cohen SP, Walega DR, Benzon HT. Diagnostic criteria and treatment of discogenic pain: a systematic review of recent clinical literature. Spine J 2013;13:1675-1689.
  • Ohtori S, Inoue G, Miyagi M, Takahashi K. Pathomechanisms of discogenic low back pain in humans and animal models. Spine J. 2015;15:1347-1355.
  • Crock H. A reappraisal of intervertebral disc lesions. Med J Australia 1970;1:983-989.
  • Singh K, Ledet E, Carl A. Intradiscal therapy: a review of current treatment modalities. Spine 2005;30:20-26.
  • Freemont A, Peacock T, Goupille P, et al. Nerve ingrowth into diseased intervertebral disc in chronic back pain. The lancet. 1997;35:178-1781.
  • Lotz JC, Haughton V, Boden SD, et al. New treatments and imaging strategies in degenerative disease of the intervertebral disks. Radiology 2012;264:6-19.
  • Carragee EJ, Hannibal M. Diagnostic evaluation of low back pain. Orthop Clin North Am 2004;35:7-16.
  • Carragee EJ, Lincoln T, Parmar VS, Alamin T. A gold standard evaluation of the “discogenic pain” diagnosis as de190 termined by provocative discography. Spine 2006;31:2115-2123.
  • Carragee EJ, Don A, Hurwitz E, et al. Does discography cause accelerated progression of degeneration changes in the lumbar disc: a ten-year cohort-controlled study. Miami, FL: International Society for the Study of the Lumbar Spine; 2009:p57
  • Chung J, Zeng Y, Wong T. Drug therapy for the treatment of
  • chronic nonspecific low back pain: systematic review and meta-analysis. Pain Physician 2013;16:685-704.
  • Kuijpers T, van Middelkoop M, Rubinstein S, et al. A systematic
  • review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain. Eur Spine J 2011;20:40-50.
  • Dean BZ, Williams FH, King JC, Goddard MJ. Pain rehabilitation:
  • Therapeutic options in pain management. Arch Phys Med Rehabil 1994;75:21-30.
  • Stevinson C, Ernst E. Risks associated with spinal manipulation.
  • Am J Med 2002;112:566-571.
  • White AP, Arnold PM, Norvell DC, et al. Pharmacologic management of chronic low back pain: synthesis of the evidence.
  • Spine 2011;36:131-143.
  • Moore A, Wiffen P, Kalso E. Antiepileptic drugs for neuropathic
  • pain and fibromyalgia. JAMA 2014;312:182-183.
  • Chou R, Huffman LH. Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med 2007;147:505-514.
  • Deyo RA, Von Korff M, Duhrkoop D. Opioids for low back pain. BMJ 2015;350:6380.
  • Schnitzer TJ. Update on guidelines for the treatment of chronic musculoskeletal pain. Clin Rheumatol 2006;25:22-29.
  • Franklin GM, Rahman EA, Turner JA, et al. Opioid use for chronic low back pain: A prospective, population-based study among injured workers in Washington state, 2002-2005. The Clin J Pain 2009;25:743-751.
  • Manchikanti L, Abdi S, Atluri S, et al. American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain:Part 2--guidance. Pain physician 2012;15:67-116.
  • Häuser W, Bock F, Engeser P, et al. Recommendations of the updated LONTS guidelines: Long-term opioid therapy for chronic noncancer pain. Schmerz Berlin, Germany. 2015;29:109-130.
  • Manchikanti L, Hirsch JA. An update on the management of chronic lumbar discogenic pain. Pain Management 2015;5:373-386.
  • Lu Y, Guzman JZ, Purmessur D, et al. Nonoperative management
  • of discogenic back pain: a systematic review. Spine 2014;39:1314-1324.
  • Guehring T, Omlor GW, Lorenz H, et al. Disc distraction shows evidence of regenerative potential in degenerated intervertebral
  • discs as evaluated by protein expression, magnetic resonance imaging, and messenger ribonucleic acid expression analysis. Spine 2006;31:1658-1665.
  • Lai A, Chow DH. Effects of traction on structural properties of degenerated disc using an in vivo rat-tail model. Spine 2010;35:1339-1345.
  • Van Middelkoop M, Rubinstein SM, Kuijpers T, et al. A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain. Eur Spine J 2011;20:19-39.
  • Wegner I, Widyahening IS, van Tulder MW, et al. Traction for low-back pain with or without sciatica. Cochrane Database Syst Rev 2013;8:CD003010.
  • Schimmel JJ, de Kleuver M, Horsting P, et al. No effect of traction in patients with low back pain: a single centre, single blind, randomized controlled trial of Intervertebral Differential Dynamics Therapy®. Eur Spine J. 2009;18:1843-1850.
  • Rubinstein SM, van Middelkoop M, Assendelft WJ, et al. Spinal manipulative therapy for chronic low-back pain: an update of a Cochrane review. Spine 2011;36:825-846.
  • Lawrence DJ, Meeker W, Branson R, et al. Chiropractic management of low back pain and low back-related leg complaints: a literature synthesis. J Manipulative Physiol Ther. 2008;31:659-674.
  • Furlan AD, Yazdi F, Tsertsvadze A, et al. Complementary and alternative therapies for back pain II. Evidence Report/Technology Assessment Number 194, AHRQ Publication 2010;10:E007.
  • Furlan AD, van Tulder M, Cherkin D, et al. Acupuncture and dry-needling for low back pain: an updated systematic review within the framework of the cochrane collaboration. Spine 2005;30:944-963.
  • Glazov G, Yelland M, Emery J. Low-dose laser acupuncture for non-specific chronic low back pain: a double-blind randomised
  • controlled trial. Acupunct Med. 2014;32:116-123.
  • Van Middelkoop M, Rubinstein SM, Verhagen AP, et al. Exercise
  • therapy for chronic nonspecific low-back pain. Best Pract Res Clin Rheumatol 2010;24:193-204.
  • Heymans MW, van Tulder MW, Esmail R, et al. Back schools for nonspecific low back pain: a systematic review within the framework of the Cochrane Collaboration Back Review Group. Spine. 2005;30:2153-2163.
  • Majchrzycki M, Kocur P, Kotwicki T. Deep tissue massage and nonsteroidal anti-inflammatory drugs for low back pain: a prospective randomized trial. The Scientific World Journal 2014:1-7.
  • Kamper SJ, Apeldoorn A, Chiarotto A, et al. Multidisciplinary
  • biopsychosocial rehabilitation for chronic low back pain: Cochrane systematic review and meta-analysis. BMJ 2015;350:h444.
  • Manchikanti L, Cash KA, McManus CD, Pampati V. Fluoroscopic
  • caudal epidural injections in managing chronic axial low back pain without disc herniation, radiculitis, or facet joint pain. J Pain Res 2012;5:381.
  • Manchikanti L, Cash KA, McManus CD, et al. A randomized, double-blind, active-controlled trial of fluoroscopic lumbar interlaminar epidural injections in chronic axial or discogenic low back pain: results of 2-year follow-up. Pain physician 2013;16:491-504.
  • Oh WS, Shim JC. A randomized controlled trial of radiofrequency
  • denervation of the ramus communicant nerve for chronic discogenic low back pain. Clin J Pain 2004;20:55-60.
  • Freeman BJ, Fraser RD, Cain CM, et al. A randomized, double-blind, controlled trial: intradiscal electrothermal therapy versus placebo for the treatment of chronic discogenic low back pain. Spine 2005;30:2369-2377.
  • Pauza KJ, Howell S, Dreyfuss P, et al. A randomized, placebo-controlled trial of intradiscal electrothermal therapy for the treatment of discogenic low back pain. Spine J 2004;4:27-35.
  • Kvarstein G, Måwe L, Indahl A, et al. A randomized double-blind controlled trial of intra-annular radiofrequency thermal disc therapy–a 12-month follow-up. Pain. 2009;145:279-286.
  • Barendse GA, van den Berg SG, Kessels AH, et al. Randomized
  • controlled trial of percutaneous intradiscal radiofrequency thermocoagulation for chronic discogenic back pain: lack of effect from a 90-second 70 C lesion. Spine 2001;26:287-292.
  • Kapural L, Vrooman B, Sarwar S, et al. A randomized,placebo-controlled trial of transdiscal radiofrequency, biacuplasty for treatment of discogenic lower back pain. Pain Med 2013;14:362-373.
  • Peng B, Pang X, Wu Y, et al. A randomized placebo-controlled trial of intradiscal methylene blue injection for the treatment of chronic discogenic low back pain. Pain 2010;149:124-129.
  • Khot A, Bowditch M, Powell J, Sharp D. The use of intradiscal
  • steroid therapy for lumbar spinal discogenic pain: a randomized controlled trial. Spine 2004;29:833-836.
  • Cao P, Jiang L, Zhuang C, et al. Intradiscal injection therapy for degenerative chronic discogenic low back pain with end plate Modic changes. Spine J 2011;11:100-106
  • Fritzell P, Hägg O, Wessberg P, Nordwall A. Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group. Spine 2001;26:2521-2532.
  • Phillips FM, Slosar PJ, Youssef JA, et al. Lumbar spine fusion
  • for chronic low back pain due to degenerative disc disease: a systematic review. Spine 2013;38:409-422.
  • Parker LM, Murrell SE, Boden SD, Horton WC. The outcome of posterolateral fusion in highly selected patients with discogenic low back pain. Spine. 1996;21:1909-1916.
  • Bydon M, Garza-Ramos DRR, Macki M, et al. Lumbar fusion versus nonoperative management for treatment of discogenic low back pain: a systematic review and metaanalysis of randomized controlled trials. J Spinal Disord Tech. 2014;27:297-304.
  • Mannion AF, Brox JI, Fairbank JC. Comparison of spinal fusion and nonoperative treatment in patients with chronic low back pain: long-term follow-up of three randomized controlled trials. Spine J 2013;13:1438-1448.
Year 2016, Volume: 43 Issue: 1, 181 - 191, 01.03.2016

Abstract

References

  • Deyo RA, Weinstein JN. Low back pain. N Engl J Med. 2001;344:363-370.
  • DePalma MJ, Ketchum JM, Saullo T. What is the source of chronic low back pain and does age play a role? Pain Med 2011;12:224-233.
  • Schwarzer AC, Aprill CN, Derby R, et al. The prevalence and clinical features of internal disc disruption in patients with chronic low back pain. Spine 1995;20:1878-1883.
  • Schwarzer AC, Aprill CN, Derby R, et al. The relative contributions
  • of the disc and zygapophyseal joint in chronic low back pain. Spine 1994;19:801-806.
  • Yakut F, Özlü MM, Taşdemir N. Kauda ekuinanın redundant sinir kökü sendromunun magnetik rezonans görüntüleme bulguları. Dicle Med J 2012;39:213-216.
  • Menkü A, Kamaşak K, Göçmez C, et al. Travmanın eşlik etmediği
  • akut monopleji nedeni olan intradural servikal disk hernisi: Olgu sunumu. J Clin Exp Invest 2014;5:112-114.
  • Köksal V, Şen A, Erdivanlı B, Özdemir B. Spinal anestezi altında yapılan lomber disk cerrahilerinin retrospektif değerlendirmesi. J Clin Exp Invest 2014;5:54-58.
  • Vernon-Roberts B, Moore RJ, Fraser RD. The natural history of age-related disc degeneration: the pathology and sequelae of tears. Spine 2007;32:2797-2804.
  • Peng B, Fu X, Pang X, et al. Prospective clinical study on natural history of discogenic low back pain at 4 years of follow-up. Pain Physician 2012;15:525-532.
  • Hurri H, Karppinen J. Discogenic pain. Pain 2004;112:225-228.
  • Peng B, Wu W, Hou S, et al. The pathogenesis of discogenic low back pain. J Bone Joint Surg Br 2005;87:62-67.
  • Vernon-Roberts B, Moore RJ, Fraser RD. The natural history of age-related disc degeneration: the influence of age and pathology on cell populations in the L4–L5 disc. Spine 2008;33:2767-2673.
  • Peng BG. Pathophysiology, diagnosis, and treatment of iscogenic
  • low back pain. World J Orthop 2013;4:42.
  • Manchikanti L, Abdi S, Atluri S, et al. An update of omprehensive
  • evidence-based guidelines for interventional techniques in chronic spinal pain. Part II: guidance and recommendations. Pain Physician 2013;16:49-283.
  • Bogduk N, Aprill C, Derby R. Lumbar Discogenic Pain:State-of-the-Art Review. Pain Med 2013;14:813-836.
  • Malik KM, Cohen SP, Walega DR, Benzon HT. Diagnostic criteria and treatment of discogenic pain: a systematic review of recent clinical literature. Spine J 2013;13:1675-1689.
  • Ohtori S, Inoue G, Miyagi M, Takahashi K. Pathomechanisms of discogenic low back pain in humans and animal models. Spine J. 2015;15:1347-1355.
  • Crock H. A reappraisal of intervertebral disc lesions. Med J Australia 1970;1:983-989.
  • Singh K, Ledet E, Carl A. Intradiscal therapy: a review of current treatment modalities. Spine 2005;30:20-26.
  • Freemont A, Peacock T, Goupille P, et al. Nerve ingrowth into diseased intervertebral disc in chronic back pain. The lancet. 1997;35:178-1781.
  • Lotz JC, Haughton V, Boden SD, et al. New treatments and imaging strategies in degenerative disease of the intervertebral disks. Radiology 2012;264:6-19.
  • Carragee EJ, Hannibal M. Diagnostic evaluation of low back pain. Orthop Clin North Am 2004;35:7-16.
  • Carragee EJ, Lincoln T, Parmar VS, Alamin T. A gold standard evaluation of the “discogenic pain” diagnosis as de190 termined by provocative discography. Spine 2006;31:2115-2123.
  • Carragee EJ, Don A, Hurwitz E, et al. Does discography cause accelerated progression of degeneration changes in the lumbar disc: a ten-year cohort-controlled study. Miami, FL: International Society for the Study of the Lumbar Spine; 2009:p57
  • Chung J, Zeng Y, Wong T. Drug therapy for the treatment of
  • chronic nonspecific low back pain: systematic review and meta-analysis. Pain Physician 2013;16:685-704.
  • Kuijpers T, van Middelkoop M, Rubinstein S, et al. A systematic
  • review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain. Eur Spine J 2011;20:40-50.
  • Dean BZ, Williams FH, King JC, Goddard MJ. Pain rehabilitation:
  • Therapeutic options in pain management. Arch Phys Med Rehabil 1994;75:21-30.
  • Stevinson C, Ernst E. Risks associated with spinal manipulation.
  • Am J Med 2002;112:566-571.
  • White AP, Arnold PM, Norvell DC, et al. Pharmacologic management of chronic low back pain: synthesis of the evidence.
  • Spine 2011;36:131-143.
  • Moore A, Wiffen P, Kalso E. Antiepileptic drugs for neuropathic
  • pain and fibromyalgia. JAMA 2014;312:182-183.
  • Chou R, Huffman LH. Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med 2007;147:505-514.
  • Deyo RA, Von Korff M, Duhrkoop D. Opioids for low back pain. BMJ 2015;350:6380.
  • Schnitzer TJ. Update on guidelines for the treatment of chronic musculoskeletal pain. Clin Rheumatol 2006;25:22-29.
  • Franklin GM, Rahman EA, Turner JA, et al. Opioid use for chronic low back pain: A prospective, population-based study among injured workers in Washington state, 2002-2005. The Clin J Pain 2009;25:743-751.
  • Manchikanti L, Abdi S, Atluri S, et al. American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain:Part 2--guidance. Pain physician 2012;15:67-116.
  • Häuser W, Bock F, Engeser P, et al. Recommendations of the updated LONTS guidelines: Long-term opioid therapy for chronic noncancer pain. Schmerz Berlin, Germany. 2015;29:109-130.
  • Manchikanti L, Hirsch JA. An update on the management of chronic lumbar discogenic pain. Pain Management 2015;5:373-386.
  • Lu Y, Guzman JZ, Purmessur D, et al. Nonoperative management
  • of discogenic back pain: a systematic review. Spine 2014;39:1314-1324.
  • Guehring T, Omlor GW, Lorenz H, et al. Disc distraction shows evidence of regenerative potential in degenerated intervertebral
  • discs as evaluated by protein expression, magnetic resonance imaging, and messenger ribonucleic acid expression analysis. Spine 2006;31:1658-1665.
  • Lai A, Chow DH. Effects of traction on structural properties of degenerated disc using an in vivo rat-tail model. Spine 2010;35:1339-1345.
  • Van Middelkoop M, Rubinstein SM, Kuijpers T, et al. A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain. Eur Spine J 2011;20:19-39.
  • Wegner I, Widyahening IS, van Tulder MW, et al. Traction for low-back pain with or without sciatica. Cochrane Database Syst Rev 2013;8:CD003010.
  • Schimmel JJ, de Kleuver M, Horsting P, et al. No effect of traction in patients with low back pain: a single centre, single blind, randomized controlled trial of Intervertebral Differential Dynamics Therapy®. Eur Spine J. 2009;18:1843-1850.
  • Rubinstein SM, van Middelkoop M, Assendelft WJ, et al. Spinal manipulative therapy for chronic low-back pain: an update of a Cochrane review. Spine 2011;36:825-846.
  • Lawrence DJ, Meeker W, Branson R, et al. Chiropractic management of low back pain and low back-related leg complaints: a literature synthesis. J Manipulative Physiol Ther. 2008;31:659-674.
  • Furlan AD, Yazdi F, Tsertsvadze A, et al. Complementary and alternative therapies for back pain II. Evidence Report/Technology Assessment Number 194, AHRQ Publication 2010;10:E007.
  • Furlan AD, van Tulder M, Cherkin D, et al. Acupuncture and dry-needling for low back pain: an updated systematic review within the framework of the cochrane collaboration. Spine 2005;30:944-963.
  • Glazov G, Yelland M, Emery J. Low-dose laser acupuncture for non-specific chronic low back pain: a double-blind randomised
  • controlled trial. Acupunct Med. 2014;32:116-123.
  • Van Middelkoop M, Rubinstein SM, Verhagen AP, et al. Exercise
  • therapy for chronic nonspecific low-back pain. Best Pract Res Clin Rheumatol 2010;24:193-204.
  • Heymans MW, van Tulder MW, Esmail R, et al. Back schools for nonspecific low back pain: a systematic review within the framework of the Cochrane Collaboration Back Review Group. Spine. 2005;30:2153-2163.
  • Majchrzycki M, Kocur P, Kotwicki T. Deep tissue massage and nonsteroidal anti-inflammatory drugs for low back pain: a prospective randomized trial. The Scientific World Journal 2014:1-7.
  • Kamper SJ, Apeldoorn A, Chiarotto A, et al. Multidisciplinary
  • biopsychosocial rehabilitation for chronic low back pain: Cochrane systematic review and meta-analysis. BMJ 2015;350:h444.
  • Manchikanti L, Cash KA, McManus CD, Pampati V. Fluoroscopic
  • caudal epidural injections in managing chronic axial low back pain without disc herniation, radiculitis, or facet joint pain. J Pain Res 2012;5:381.
  • Manchikanti L, Cash KA, McManus CD, et al. A randomized, double-blind, active-controlled trial of fluoroscopic lumbar interlaminar epidural injections in chronic axial or discogenic low back pain: results of 2-year follow-up. Pain physician 2013;16:491-504.
  • Oh WS, Shim JC. A randomized controlled trial of radiofrequency
  • denervation of the ramus communicant nerve for chronic discogenic low back pain. Clin J Pain 2004;20:55-60.
  • Freeman BJ, Fraser RD, Cain CM, et al. A randomized, double-blind, controlled trial: intradiscal electrothermal therapy versus placebo for the treatment of chronic discogenic low back pain. Spine 2005;30:2369-2377.
  • Pauza KJ, Howell S, Dreyfuss P, et al. A randomized, placebo-controlled trial of intradiscal electrothermal therapy for the treatment of discogenic low back pain. Spine J 2004;4:27-35.
  • Kvarstein G, Måwe L, Indahl A, et al. A randomized double-blind controlled trial of intra-annular radiofrequency thermal disc therapy–a 12-month follow-up. Pain. 2009;145:279-286.
  • Barendse GA, van den Berg SG, Kessels AH, et al. Randomized
  • controlled trial of percutaneous intradiscal radiofrequency thermocoagulation for chronic discogenic back pain: lack of effect from a 90-second 70 C lesion. Spine 2001;26:287-292.
  • Kapural L, Vrooman B, Sarwar S, et al. A randomized,placebo-controlled trial of transdiscal radiofrequency, biacuplasty for treatment of discogenic lower back pain. Pain Med 2013;14:362-373.
  • Peng B, Pang X, Wu Y, et al. A randomized placebo-controlled trial of intradiscal methylene blue injection for the treatment of chronic discogenic low back pain. Pain 2010;149:124-129.
  • Khot A, Bowditch M, Powell J, Sharp D. The use of intradiscal
  • steroid therapy for lumbar spinal discogenic pain: a randomized controlled trial. Spine 2004;29:833-836.
  • Cao P, Jiang L, Zhuang C, et al. Intradiscal injection therapy for degenerative chronic discogenic low back pain with end plate Modic changes. Spine J 2011;11:100-106
  • Fritzell P, Hägg O, Wessberg P, Nordwall A. Lumbar fusion versus nonsurgical treatment for chronic low back pain: a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group. Spine 2001;26:2521-2532.
  • Phillips FM, Slosar PJ, Youssef JA, et al. Lumbar spine fusion
  • for chronic low back pain due to degenerative disc disease: a systematic review. Spine 2013;38:409-422.
  • Parker LM, Murrell SE, Boden SD, Horton WC. The outcome of posterolateral fusion in highly selected patients with discogenic low back pain. Spine. 1996;21:1909-1916.
  • Bydon M, Garza-Ramos DRR, Macki M, et al. Lumbar fusion versus nonoperative management for treatment of discogenic low back pain: a systematic review and metaanalysis of randomized controlled trials. J Spinal Disord Tech. 2014;27:297-304.
  • Mannion AF, Brox JI, Fairbank JC. Comparison of spinal fusion and nonoperative treatment in patients with chronic low back pain: long-term follow-up of three randomized controlled trials. Spine J 2013;13:1438-1448.
There are 88 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Adem Yıldırım

Publication Date March 1, 2016
Submission Date March 29, 2016
Published in Issue Year 2016 Volume: 43 Issue: 1

Cite

APA Yıldırım, A. (2016). Chronic Discogenic Low Back Pain and Non-Surgical Treatment Methods: An Update. Dicle Tıp Dergisi, 43(1), 181-191. https://doi.org/10.5798/diclemedj.0921.2016.01.0665
AMA Yıldırım A. Chronic Discogenic Low Back Pain and Non-Surgical Treatment Methods: An Update. diclemedj. March 2016;43(1):181-191. doi:10.5798/diclemedj.0921.2016.01.0665
Chicago Yıldırım, Adem. “Chronic Discogenic Low Back Pain and Non-Surgical Treatment Methods: An Update”. Dicle Tıp Dergisi 43, no. 1 (March 2016): 181-91. https://doi.org/10.5798/diclemedj.0921.2016.01.0665.
EndNote Yıldırım A (March 1, 2016) Chronic Discogenic Low Back Pain and Non-Surgical Treatment Methods: An Update. Dicle Tıp Dergisi 43 1 181–191.
IEEE A. Yıldırım, “Chronic Discogenic Low Back Pain and Non-Surgical Treatment Methods: An Update”, diclemedj, vol. 43, no. 1, pp. 181–191, 2016, doi: 10.5798/diclemedj.0921.2016.01.0665.
ISNAD Yıldırım, Adem. “Chronic Discogenic Low Back Pain and Non-Surgical Treatment Methods: An Update”. Dicle Tıp Dergisi 43/1 (March 2016), 181-191. https://doi.org/10.5798/diclemedj.0921.2016.01.0665.
JAMA Yıldırım A. Chronic Discogenic Low Back Pain and Non-Surgical Treatment Methods: An Update. diclemedj. 2016;43:181–191.
MLA Yıldırım, Adem. “Chronic Discogenic Low Back Pain and Non-Surgical Treatment Methods: An Update”. Dicle Tıp Dergisi, vol. 43, no. 1, 2016, pp. 181-9, doi:10.5798/diclemedj.0921.2016.01.0665.
Vancouver Yıldırım A. Chronic Discogenic Low Back Pain and Non-Surgical Treatment Methods: An Update. diclemedj. 2016;43(1):181-9.