Psoriasis Hastalarında Biyolojik Tedavinin Sistemik İnflamatuvar Belirteçler ve Plateletcrit Üzerine Etkisi

Year 2016, Volume: 43 Issue: 4, 477 - 476, 25.12.2016

Bengü Çevirgen Cemil Hatice Ataş

Abstract

Amaç: Psoriasis keratinositlerin anormal
proliferasyonu ve inflamatuvar hücre infiltrasyonu ile karakterize
kronik inflamatuvar bir deri hastalığıdır. İnflamatuvar hücre ve
sitokinler hastaların dokuları ile birlikte periferal kanda da tespit
edilmektedir. Bugüne kadar psoriasis vulgariste pek çok inflamatuvar
belirteç bildirilmiştir. Çalışmamızın amacı psoriasisli hastalarda
biyolojik tedavi öncesi ve sonrası nötrofil/lenfosit oranı (NLO),
lenfosit/monosit (LMO), platelet/lenfosit oranı (PLO), RDW/platelet
(RPO) gibi sistemik inflamatuvar belirteçler ile plateletcrit (PCT)’ nin
değişimini araştırmaktır.

Yöntemler: Biyolojik ajanlar ile tedavi edilmiş 42
psoriasis vulgaris hastası geriye dönük olarak değerlendirilmiştir.
Hastaların demografik bilgileri, klinik verileri ve tam kan sayımı
biyolojik tedavinin başlangıcından önce ve tedavi sonrası 3. ayda
değerlendirilmiştir.

Bulgular: Sedimentasyon, C-reaktif protein (CRP),
nötrofil, trombosit, PCT, RDW, NLO ve PLO değerleri tedavi sonrası
tedavi öncesi döneme göre istatistiksel anlamlı olarak azalmıştır
(p<0.05). Ek olarak MPV, PDW, LMR ve RPR sonuçları değerlendirilmiş
tedavi öncesi ve sonrası arasında istatistiksel anlamlı bir fark
bulunamamıştır (p>0.05).

Sonuç: NLO, PLO ve PCT psoriasis vulgaris hastalarının
biyolojik ajan ile tedavi etkinliğinin değerlendirilmesinde bir
belirteç olarak kullanılabilirler.

Keywords

biy olojik tedavi, biyolojik belirteçler

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