Evaluation of the effect of red cell distribution width on the development of acute renal failure in patients with sepsis

Year 2017, Volume: 44 Issue: 2, 191 - 198, 07.06.2017

Ali Veysel Kara Sema Tanrikulu Emre Aydın Fatma Aydın Yaşar Yıldırım Zülfükar Yılmaz Ali Kemal Kadiroğlu Mehmet Emin Yılmaz Hikmet Soylu

https://doi.org/10.5798/dicletip.319769

Cited By: 1

Abstract

Objective: Acute kidney injury (AKI) is an important clinical entity that is known to increase mortality in patients with
sepsis. Erythrocyte maturation and proliferation are inhibited by pro-inflammatory cytokines; these cytokines exert
effects on red cell distribution width (RDW) well. Based on this knowledge; our aim in this study was to evaluate the
impact of RDW on acute kidney injury in patients with sepsis.
Methods: 120 patients diagnosed with sepsis and admitted to intesive care unit (ICU) and treated between 2009-2013
were retrospectively evaluated. Patients were divided into two groups as follows: group 1 (RDW≥16.8) and group 2
(RDW<16.8). Multiple logistic regression analysis was used to determine the association between RDW and AKI and
mortality.
Results: There was a statistically significant relationship between AKI and RDW (p<0.001, OR=11.52) but there were
no statistically significant relationship between AKI and sex, age, serum lactate levels as well as SOFA score. Also,
there were statistically significant relationship between mortality and RDW (p=0.044, OR=5), serum lactate levels
(p=0.030) and SOFA score (p<0.001). RDW was found associated with both AKI and mortality.
Conclusions: Results suggest that RDW is an important parameter for predicting development of AKI and mortality in
ICU patients with sepsis.

Keywords

Acute kidney injury, Sepsis

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