Yeni Tanılı Diyabetes Mellitus Hastalarında Peripapiller Retina Sinir Lifi Tabakası Ve Subfoveal Koroid Kalınlığının Spektralis OCT İle Değerlendirilmesi

Year 2016, Volume: 43 Issue: 3, 435 - 440, 01.09.2016

Muhammed Şahin Alparslan Şahin Faruk Kılınç Zeynep Gürsel Özkurt Ümit Karaalp Harun Yüksel Fatih Mehmet Türkcü İhsan Çaça

Abstract

Amaç: Bu çalışmada amacımız, yeni tanı alan ve herhangi
bir diyabetik retinopati (DR) bulgusu olmayan tip 2
diyabetes mellituslu (DM) olgularla sağlıklı bireylerin peripapiller
retina sinir lifi tabakası (pRSLT) ve koroid tabakası
kalınlıklarını karşılaştırmaktır.
Yöntemler: Çalışmaya Endokrin polikliniğinden yeni tanı
almış ve DR’si olmayan DM’li hastalar ile sağlıklı kontrol
grubu dahil edildi. Olguların Spectral-Domain optik koherens
tomografi (spektralis OKT) cihazı ile EDI modunda
(enhanced depth imaging- artırılmış derinlik görüntülemesi)
horizontal düzlemde taraması yapıldı. Alınan görüntülerden
fovea merkezinden, fovea merkezine 1000 μm
temporal ve nazalden koroid kalınlıkları ölçümü yapıldı.
Ayrıca aynı cihazla pRSLT kalınlık ölçümü yapıldı.
Bulgular: Çalışmaya DR’si olmayan 28 yeni tanılı DM
hastasının 28 gözü ile 28 kontrol grubunun 28 gözü dahil
edildi. Yaş, cinsiyet, sferik ekivalan, düzeltilmiş en iyi
görme keskinliği, göz içi basıncı ve aksiyel uzunluk değerlerinde
gruplar arasında anlamlı farklılık saptanmadı.
Subfoveal ve temporal alanda koroid kalınlığının yeni tanılı
DM grubunda kontrol grubuna göre daha ince olduğu
saptandı (sırasıyla p=0,04, p=0,006). pRNFL analizinde
ise averaj, nazal ve temporal süperior kadranlar yeni tanılı
DM grubunda kontrol grubuna göre anlamlı olarak daha
ince bulundu. Diğer pRNFL kadranlarında anlamlı bir fark
saptanmadı.
Sonuç: Çalışmamızın verileri değerlendirildiğinde yeni
tanılı DM’li hastalarda DR bulguları olmaksızın koroid tabakasında
incelmenin yanında pRSLT’de bazı incelmelerin
(özellikle averaj, nazal ve temporal süperior kadranlarda)
olabileceğini söylemek mümkün görünmektedir

Keywords

Diyabetes mellitus, koroid kalınlığı, retina sinir lifi tabakası kalınlığı

Evaluation Of The Peripapillary Retinal Nerve Fiber Layer And Subfoveal Choroidal Thickness In Naive Patients With Diabetes Mellitus With Spectralis OCT

Abstract

Objective: We aimed to compare the peripapillary retinal nerve fiber layer (pRNFL) and choroidal thickness in na­ive type 2 diabetic patients without diabetic retinopathy (DR) with healthy subjects. Methods: The study included newly diagnosed diabetic patients without DR and healthy control subjects. Hori­zontal plane scan of choroid was performed using en­hanced depth imaging (EDI) mode of spectral-domain optical coherence tomography (SD-OCT). The choroidal thickness was measured at the central fovea and at 1000 μm nasal and temporal from the center of the fovea. In addition, the same measurements were performed for pRNFL thickness. Results: The study included 28 eyes of the 28 newly di­agnosed with diabetic patients without DR and 28 eyes of the 28 healthy subjects. Age, gender, spherical equivalent refraction, best-corrected visual acuity, intraocular pres­sure and axial length were not difference between groups. The choroidal thickness of subfoveal and temporal areas were thinner in the naive DM group than that of control group (p = 0.04, p = 0.006, respectively.). In pRNFL analy­sis, average, nasal and superior temporal quadrants were significantly thinner in the newly diagnosed with DM than those of control group. There were no significant differ­ences in other pRNFL quadrants. Conclusion: When the data were analyzed, in addition to thinning of the choroid layer, it is possible to say that some thinning can be observed in the pRNFL particularly at the average, nasal and temporal superior quadrants in the patients newly diagnosed with DM without DR.

Keywords

Choroidal thickness, diabetes mellitus, retinal nerve fiber layer thickness

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