Prevalence of Various Hemoglobinopathies-An Experience from Tertiary Care Centre

Year 2019, Volume: 46 Issue: 2, 269 - 276, 11.06.2019

Promil Jain , Monika Gupta Shivani Dua Nisha Marwah Meenu Gill Rajeev Sen

https://doi.org/10.5798/dicletip.539869

Abstract

Objective:
To find out the prevalence of thalassemias and various other hemoglobinopathies
in state of Haryana and to assess the role of High performance liquid
chromatography (HPLC) for accurate and quick diagnosis of various hemoglobin
disorders.

Methods:
This study was conducted in Pt. B. D. Sharma, PGIMS, Rohtak from July 2010 to
October 2016 for hemoglobin variant screening by HPLC of total of 4275
patients, selected through multistage random sampling technique.

Results:
Among 4275 total cases surveyed, normal hemoglobin pattern was observed in 3862
(90.3%) and abnormal hemoglobin fractions on HPLC were detected in 413 (9.7%).
Βeta (β) thalassemia trait was predominant abnormality found in a total of 318
cases (7.4%). There were 19 cases of β-thalassemia major and 24 of
β-thalassemia intermedia. Other abnormal patterns found were HbE (trait in 11
and HbE disease in 6 cases), Hb S (2 cases each of sickle cell disease and
sickle cell trait), 2 cases of high Hb F (1 case each of heterozygous and
homozygous HPFH), 11 cases of Hb D Punjab along with 2 cases of Hb D Iran, 1
case of Hb C and 2 cases each of double heterozygotes for Hb E/ β-thalassemia
and Hb S/ β-thalassemia.

Conclusion:
There is high prevalence of hemoglobinopathies in this region and HPLC forms a
rapid and accurate tool in early detection and management of various
hemoglobinopathies.

Keywords

Hemoglobinopathies, Thalassemia

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