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Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication

Year 2012, Volume: 39 Issue: 1, 54 - 57, 01.03.2012
https://doi.org/10.5798/diclemedj.0921.2012.01.0094

Abstract

Objective: Success rates of amoxicillin, clarithromycin, and proton-pump inhibitor therapy in the Helicobacter pylori (Hp) eradication have been decreasing. The aim of this study was to investigate the impact of bismuth subcitrate ad-dition to triple therapy. Materials and methods: 148 patients diagnosed Hp infection with both histology and Hp stool antigen (HpSA) tests were examined retrospectively. The patients were divided into 3 groups according to the eradication therapy. The first group received triple therapy with claritromycine 2x 500 mg, amoxicilline 2x1 g and PPI 2x1 for 14 days (n=40). The second group had bismuth subcitrate 4x120 mg with triple therapy for 14 days (n=73). The third group received 14 days pretreatment with bismuth subcitrate 4x1 together with PPI 2x1 then had triple therapy for 14 days (n=35). (14)C urea breath and HpSA tests were used to detect posttreatment H.pylori status. Results: There were no statistical difference between the groups in terms of gender and age (p > 0.05). In group one 12 patients, in group two 20 patients and in group three 10 patients were identified as Hp positive after treatment. Eradication rates were 70% for group one, 72.6% for group two and 71.4% for group three respectively. There was no statistical difference between the groups in terms of eradication rates of treatment (p > 0.05). Conclusions: The addition of bismuth to conventional triple therapy did not affect treatment success rates.

References

  • Graham DY, Fischbach L. Helicobacter pylori treat- ment in the era of increasing antibiotic resistance. Gut 2010;59(8):1143-53.
  • Gisbert JP, Pajares JM. Treatment of Helicobacter py- lori infection: the past and the future. Eur J Intern Med 2010;21(5):357-9.
  • Paoluzi OA, Visconti E, Andrei F, et al. Ten and eight-day sequential therapy in comparison to standart triple therapy for eradicating Helicabacter pylori infection: a randomized controlled study on efficay and tolerability. J Clin Gatsro- enterol 2010;44(4):261-6.
  • Malfertheiner P, Megraud F, O’Morain C, et al. Current con- cepts in the management of Helicobacter pylori infection: Maastricht III Consensus report. Gut 2007;56(6):772-81.
  • Kadayıfçı A, Büyükhatipoğlu H, Cemil Savas M, et al. Eradi- cation of Helicobacter pylori with triple therapy: an epide- miologic analysis of trends in Turkey over 10 years. Clin Ther. 2006; 28(11): 1960-6.
  • Schindler R, Heemann U, Haug U, et al. Bismuth coating of non-tunneled haemodialysis catheters reduces bacterial colonization: a randomized controlled trial. Nephrol Dial Transplant. 2010;25(8):2651-6.
  • O’Connor A, Gisbert JP, McNamara D, et al. Treatment of Helicobacter pylori infection 2011. Helicobacter 2011;16 (Suppl.1) 53-8.
  • Gümürdülü Y, Serin E, Özer B, et al. Low eradication rate of Helicobacter pylori with triple 7-14 days and quadruple therapy in Turkey. World J Gastroenterol 2004; 10(5): 668- 71.
  • Leong RW. Differances in peptik ulcer between the east and the west. Gastroenterol Clin N Am 2009; 38(2): 363-79.
  • Qua CS, Manikam J, Goh KL. Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter py- lori eradication regime in Asian patients: is it still effective 10 years on? J Dig Dis 2010;11(4):244–8.
  • Sasaki M, Ogasawara N, Utsumi K, et al. Changes in 12- year first-line eradication rate of Helicobacter pylori based on triple therapy with proton pump inhibitor, Amoxicillin and Clarithromycin. J Clin Biochem Nutr 2010;47(1):53–8.
  • Özer B, Serin E, Coşar A ve ark. Helicobacter pylori eradi- kasyon tedavisinde lansoprazol, klaritromisin, amaoksisilin ile ranitidin bizmut sitrat + lansoprazol, klaritromisin, ama- oksisilin rejiminin etkinliğinin karşılaştırılması. Akademik Gastroenteroloji Dergisi 2004; 3(3):125-8.
  • Uygun A, Tüzün A, Yeşilova Z ve ark. Helicobacter py- lori eradikasyon tedavisinde 7 ve 14 günlük lansoprazol, klaritromisin, amaoksisilin protokolünün karşılaştırılması. Akademik Gastroenteroloji Dergisi 2005; 4(3): 172-5.
  • Çırak MY, Engin D, Ünal S, et al. Monitoring of Helico- bacter pylori resistance to clarithromycin by real-time PCR assay in gastric biopsy specimens over a 4-year period in Turkey. Helicobacter 2007; 12(4): 449.
  • Özden A, Seven G, Bektaş M. Effectiveness of different treatment regimens in Helicobacter pylori eradication; Ten- year’s experience of a single institution. Turk J Gastroen- terol 2010;21(3):218-23.
  • Luther J, Higgins PD, Schoenfeld PS, et al. Empiric quadru- ple vs. triple therapy for primary treatment of Helicobacter pylori infection: systematic rewiev and meta-analysis of ef- ficacy and tolerability. Am J Gastroenterol 2010; 105(1): 65-73.
  • Sun Q, Liang X, Zheng Q, et al. High efficacy of 14-day triple therapy-based, bismuth-containing quadruple therapy for initial Helicobacter pylori eradication. Helicobacter 2010;15(3):233-8.
  • Lee BH, Kim N, Hwang TJ, et al. Bismuth-containing qua- druple therapy as second line treatment Helicobacter py- lori infection: effect of treatment duration and antibiotic resistance on the eradication rate in Korea. Helicobacter 2010;15(1):38-45.
  • Alkım H, İscan M, Öz F. Effectiveness of ranitidine bismuth citrate and proton pump inhibitor based triple therapies of Helicobacter pylori in Turkey. Libyan J Med 2011;6:8412.

Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication

Year 2012, Volume: 39 Issue: 1, 54 - 57, 01.03.2012
https://doi.org/10.5798/diclemedj.0921.2012.01.0094

Abstract

Amaç: Helicobacter pylori (Hp) eradikasyonunda ilk basamak tedavi olan amoksisilin, klaritromisin ve proton pompa inhibitörü tedavisinin başarı oranları düşmektedir. Klasik üçlü tedaviye bizmut subsitrat eklenmesinin Hp eradikasyon başarısına etkisinin araştırılması amaçlandı. Gereç ve yöntem: Helicobacter pylori enfeksiyonu teşhisi, histoloji ve gaita antijen (HpSA) testlerinin her ikisinin bir-likte pozitifliğiyle konulan ve eradikasyon tedavisi alan 148 hasta retrospektif olarak incelenmiştir. Hastalar aldıkları tedavi şemalarına göre 3 gruba ayrılmıştır. İlk grupta 14 gün klasik üçlü tedavi (klaritromisin 2x500 mg, amoksisilin 2x1 gr ve proton pompa inhibitörü 2x1) (n:40), ikinci grupta 14 gün klasik üçlü tedavi ve beraberinde 120 mg bizmut subsitrat 4x1 tablet (n:73), üçüncü grupta ise klasik tedavi öncesi bizmut subsitrat 4x1 ve proton pompa inhibitörü 2x1 en az ondört gün alıp sonrasında 14 gün klasik tedavi alan hastalar (n:35) yer almıştır. Tedavi sonrası Hp eradikas-yon kontrolünde C-14 üre - nefes ve HpSA testleri kullanıldı. Bulgular: Hasta grupları arasında cinsiyet ve yaş açısından istatistiksel fark yoktu (p>0,05). Klasik tedavi grubunda 12 hastada, klasik tedavi ve bizmut subsitrat alan 20 hastada, bizmut subsitrat ile proton pompa inhibitörü tedavisi alıp sonra klasik tedavi alan 10 hastada tedavi sonrası Hp pozitif olarak tespit edildi. Eradikasyon oranları sırası ile klasik tedavi grubunda %70, klasik üçlü tedavi ve bizmut subsitratı beraber alanlarda %72,6, bizmut ve proton pompa inhibitörü tedavisi alıp sonrasında klasik tedavi alanlarda %71,4 olarak bulunmuştur. Her üç grup arasında Hp eradi-kasyon başarısı açısından istatistiksel olarak anlamlı fark yoktur (p > 0,05). Sonuç: Helicobacter pylori eradikasyonunda birinci basamak tedavi olan klasik üçlü tedaviye bizmut eklenmesi tedavi başarı oranlarını etkilememiştir.

References

  • Graham DY, Fischbach L. Helicobacter pylori treat- ment in the era of increasing antibiotic resistance. Gut 2010;59(8):1143-53.
  • Gisbert JP, Pajares JM. Treatment of Helicobacter py- lori infection: the past and the future. Eur J Intern Med 2010;21(5):357-9.
  • Paoluzi OA, Visconti E, Andrei F, et al. Ten and eight-day sequential therapy in comparison to standart triple therapy for eradicating Helicabacter pylori infection: a randomized controlled study on efficay and tolerability. J Clin Gatsro- enterol 2010;44(4):261-6.
  • Malfertheiner P, Megraud F, O’Morain C, et al. Current con- cepts in the management of Helicobacter pylori infection: Maastricht III Consensus report. Gut 2007;56(6):772-81.
  • Kadayıfçı A, Büyükhatipoğlu H, Cemil Savas M, et al. Eradi- cation of Helicobacter pylori with triple therapy: an epide- miologic analysis of trends in Turkey over 10 years. Clin Ther. 2006; 28(11): 1960-6.
  • Schindler R, Heemann U, Haug U, et al. Bismuth coating of non-tunneled haemodialysis catheters reduces bacterial colonization: a randomized controlled trial. Nephrol Dial Transplant. 2010;25(8):2651-6.
  • O’Connor A, Gisbert JP, McNamara D, et al. Treatment of Helicobacter pylori infection 2011. Helicobacter 2011;16 (Suppl.1) 53-8.
  • Gümürdülü Y, Serin E, Özer B, et al. Low eradication rate of Helicobacter pylori with triple 7-14 days and quadruple therapy in Turkey. World J Gastroenterol 2004; 10(5): 668- 71.
  • Leong RW. Differances in peptik ulcer between the east and the west. Gastroenterol Clin N Am 2009; 38(2): 363-79.
  • Qua CS, Manikam J, Goh KL. Efficacy of 1-week proton pump inhibitor triple therapy as first-line Helicobacter py- lori eradication regime in Asian patients: is it still effective 10 years on? J Dig Dis 2010;11(4):244–8.
  • Sasaki M, Ogasawara N, Utsumi K, et al. Changes in 12- year first-line eradication rate of Helicobacter pylori based on triple therapy with proton pump inhibitor, Amoxicillin and Clarithromycin. J Clin Biochem Nutr 2010;47(1):53–8.
  • Özer B, Serin E, Coşar A ve ark. Helicobacter pylori eradi- kasyon tedavisinde lansoprazol, klaritromisin, amaoksisilin ile ranitidin bizmut sitrat + lansoprazol, klaritromisin, ama- oksisilin rejiminin etkinliğinin karşılaştırılması. Akademik Gastroenteroloji Dergisi 2004; 3(3):125-8.
  • Uygun A, Tüzün A, Yeşilova Z ve ark. Helicobacter py- lori eradikasyon tedavisinde 7 ve 14 günlük lansoprazol, klaritromisin, amaoksisilin protokolünün karşılaştırılması. Akademik Gastroenteroloji Dergisi 2005; 4(3): 172-5.
  • Çırak MY, Engin D, Ünal S, et al. Monitoring of Helico- bacter pylori resistance to clarithromycin by real-time PCR assay in gastric biopsy specimens over a 4-year period in Turkey. Helicobacter 2007; 12(4): 449.
  • Özden A, Seven G, Bektaş M. Effectiveness of different treatment regimens in Helicobacter pylori eradication; Ten- year’s experience of a single institution. Turk J Gastroen- terol 2010;21(3):218-23.
  • Luther J, Higgins PD, Schoenfeld PS, et al. Empiric quadru- ple vs. triple therapy for primary treatment of Helicobacter pylori infection: systematic rewiev and meta-analysis of ef- ficacy and tolerability. Am J Gastroenterol 2010; 105(1): 65-73.
  • Sun Q, Liang X, Zheng Q, et al. High efficacy of 14-day triple therapy-based, bismuth-containing quadruple therapy for initial Helicobacter pylori eradication. Helicobacter 2010;15(3):233-8.
  • Lee BH, Kim N, Hwang TJ, et al. Bismuth-containing qua- druple therapy as second line treatment Helicobacter py- lori infection: effect of treatment duration and antibiotic resistance on the eradication rate in Korea. Helicobacter 2010;15(1):38-45.
  • Alkım H, İscan M, Öz F. Effectiveness of ranitidine bismuth citrate and proton pump inhibitor based triple therapies of Helicobacter pylori in Turkey. Libyan J Med 2011;6:8412.
There are 19 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Ayhan Hilmi Çekin This is me

Nur Turgut Tükel This is me

Yeşim Çekin This is me

Cem Sezer This is me

Ezel Taşdemir This is me

Publication Date March 1, 2012
Submission Date March 2, 2015
Published in Issue Year 2012 Volume: 39 Issue: 1

Cite

APA Çekin, A. H., Tükel, N. T., Çekin, Y., Sezer, C., et al. (2012). Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication. Dicle Tıp Dergisi, 39(1), 54-57. https://doi.org/10.5798/diclemedj.0921.2012.01.0094
AMA Çekin AH, Tükel NT, Çekin Y, Sezer C, Taşdemir E. Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication. diclemedj. March 2012;39(1):54-57. doi:10.5798/diclemedj.0921.2012.01.0094
Chicago Çekin, Ayhan Hilmi, Nur Turgut Tükel, Yeşim Çekin, Cem Sezer, and Ezel Taşdemir. “Effect of Bismuth Addition to the Triple Therapy of Helicobacter Pylori Eradication”. Dicle Tıp Dergisi 39, no. 1 (March 2012): 54-57. https://doi.org/10.5798/diclemedj.0921.2012.01.0094.
EndNote Çekin AH, Tükel NT, Çekin Y, Sezer C, Taşdemir E (March 1, 2012) Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication. Dicle Tıp Dergisi 39 1 54–57.
IEEE A. H. Çekin, N. T. Tükel, Y. Çekin, C. Sezer, and E. Taşdemir, “Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication”, diclemedj, vol. 39, no. 1, pp. 54–57, 2012, doi: 10.5798/diclemedj.0921.2012.01.0094.
ISNAD Çekin, Ayhan Hilmi et al. “Effect of Bismuth Addition to the Triple Therapy of Helicobacter Pylori Eradication”. Dicle Tıp Dergisi 39/1 (March 2012), 54-57. https://doi.org/10.5798/diclemedj.0921.2012.01.0094.
JAMA Çekin AH, Tükel NT, Çekin Y, Sezer C, Taşdemir E. Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication. diclemedj. 2012;39:54–57.
MLA Çekin, Ayhan Hilmi et al. “Effect of Bismuth Addition to the Triple Therapy of Helicobacter Pylori Eradication”. Dicle Tıp Dergisi, vol. 39, no. 1, 2012, pp. 54-57, doi:10.5798/diclemedj.0921.2012.01.0094.
Vancouver Çekin AH, Tükel NT, Çekin Y, Sezer C, Taşdemir E. Effect of bismuth addition to the triple therapy of Helicobacter pylori eradication. diclemedj. 2012;39(1):54-7.