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A newborn with diabetic ketoacidosis and thalassemia major: A rare case

Year 2012, Volume: 39 Issue: 1, 142 - 144, 01.03.2012
https://doi.org/10.5798/diclemedj.0921.2012.01.0115

Abstract

Diabetic ketoacidosis is a systemic situation caused by absolute insulin deficiency and characterized by hyperglyce-mia, ketonemia, acidemia, glycosuria and ketonuria. Thalassemia Major is a very serious hereditary blood disorder due to low levels or absence of "beta globulin" chain, characterized by requiring a blood transfusion from 3-4. month of life due to the relatively short life of red cells. We, herein presented a rare case of 20 day-old newborn with anemia, hyperglycemia, vomiting, acidosis being diag-nosed as thalassemia major that required blood transfusion in the early period of life and diabetic ketoacidosis with-out ketonuria who born from 24 year old father carrier of thalassemia and 23-year-old mother with carrier of thalas-semia and gestational diabetes. The case was presented in order to emphasize that diabetic ketoacidosis can occur in newborns without ketonuria and thalassemia major may cause anemia in the early period of life due to hyperglycemia and acidosis.

References

  • Polak M, Shield J. Neonatal and very-early-onset diabetes mellitus. Semin Neonatol 2004;9(1):59-65.
  • Von Muhlendahl KE, Herkenhoff H. Long-term course of neonatal diabetes. N Engl J Med 1995;333:704-8.
  • Muncie HL Jr, Campbell J. Alpha and beta thalassemia. Am Fam Physician 2009;80(4):339-44.
  • Lanzskowsky P. Thalassemias. In: Lanzskowsky P.(ed). Man- uel of Pediatric Hematology and Oncology. 4th ed.Elsevier Academic Press. California 2005:181-191.
  • Cunninghan MJ, Sankaran VG, Nathan DG, Orkin SH. The Thalassemias. In: Orkin SH, Nathan DG, Ginsburg D, Look AT,Fisher DE, Lux SE.(eds) 7th ed. Elsevier Saunders, Philadelphia: 2009:1015-1106.
  • Abacı A, Razi CH, Ozdemir O, Hızlı S, Kıslal F, Argas PI, Kabakuş N. Neonatal diabetes mellitus accompanied by diabetic ketoacidosis and mimicking neonatal sepsis: a case report. J Clin Res Pediatr Endocrinol 2010;2(3):131-3.
  • Woolley SL, Saranga S. Neonatal diabetes mellitus: A rare but important diagnosis in the critically ill infant. Eur J Emerg Med 2006;13(3):349-351.
  • Flechtner I, Vaxillaire M, Cave H, Scharfmann R, Froguel P, Polak M. Neonatal hyperglycaemia and abnormal de- velopment of the pancreas. Best Pract Res Clin Endocrinol Metab 2008;22(1):17-40.

A newborn with diabetic ketoacidosis and thalassemia major: A rare case

Year 2012, Volume: 39 Issue: 1, 142 - 144, 01.03.2012
https://doi.org/10.5798/diclemedj.0921.2012.01.0115

Abstract

Diyabetik ketoasidoz mutlak insülin yetersizliğine bağlı gelişen ve genellikle hiperglisemi, ketonemi, asidemi, glikozüri, ketoüri ile karakterize sistemik bir durumdur. Talasemi Major "beta globulin" zincirinin yapılamaması veya az yapıl-ması nedeniyle eritrosit ömrünün kısa olmasından kaynaklanan, hayatın 3.-4. ayında anemi bulguları görülmeye baş-layan ve zamanla sürekli kan nakli gerektiren çok ciddi kalıtsal bir kan hastalığıdır. Olgu sunumumuzda 24 yaşındaki talasemi taşıyıcısı bir baba ve 23 yaşındaki talasemi taşıyıcısı ve gestasyonel di-yabetli bir anneden doğan, anemi, hiperglisemi, kusma ve asidoz tablosuyla servisimize yatırılan ketonüri olmadığı halde diyabetik ketoasidoz ve erken dönemde eritrosit transfüzyonu gerektiren talasemi majorlu 20 günlük nadir görü-len bir olguyu sunduk. Yenidoğanlarda diyabetik ketoasidoz tablosunun ketonüri olmadan da görülebileceği ve talasemi major olgularında hiperglisemi ve asidozla birlikte erken dönemde aneminin de ortaya çıkabileceğine vurgu yapmak için olgu sunuldu.

References

  • Polak M, Shield J. Neonatal and very-early-onset diabetes mellitus. Semin Neonatol 2004;9(1):59-65.
  • Von Muhlendahl KE, Herkenhoff H. Long-term course of neonatal diabetes. N Engl J Med 1995;333:704-8.
  • Muncie HL Jr, Campbell J. Alpha and beta thalassemia. Am Fam Physician 2009;80(4):339-44.
  • Lanzskowsky P. Thalassemias. In: Lanzskowsky P.(ed). Man- uel of Pediatric Hematology and Oncology. 4th ed.Elsevier Academic Press. California 2005:181-191.
  • Cunninghan MJ, Sankaran VG, Nathan DG, Orkin SH. The Thalassemias. In: Orkin SH, Nathan DG, Ginsburg D, Look AT,Fisher DE, Lux SE.(eds) 7th ed. Elsevier Saunders, Philadelphia: 2009:1015-1106.
  • Abacı A, Razi CH, Ozdemir O, Hızlı S, Kıslal F, Argas PI, Kabakuş N. Neonatal diabetes mellitus accompanied by diabetic ketoacidosis and mimicking neonatal sepsis: a case report. J Clin Res Pediatr Endocrinol 2010;2(3):131-3.
  • Woolley SL, Saranga S. Neonatal diabetes mellitus: A rare but important diagnosis in the critically ill infant. Eur J Emerg Med 2006;13(3):349-351.
  • Flechtner I, Vaxillaire M, Cave H, Scharfmann R, Froguel P, Polak M. Neonatal hyperglycaemia and abnormal de- velopment of the pancreas. Best Pract Res Clin Endocrinol Metab 2008;22(1):17-40.
There are 8 citations in total.

Details

Primary Language Turkish
Journal Section Case Reports
Authors

İlyas Yolbaş This is me

Velat Şen This is me

Hasan Balık This is me

Selvi Kelekçi This is me

Kenan Haspolat This is me

Ünal Uluca This is me

İlhan Tan This is me

Publication Date March 1, 2012
Submission Date March 2, 2015
Published in Issue Year 2012 Volume: 39 Issue: 1

Cite

APA Yolbaş, İ., Şen, V., Balık, H., Kelekçi, S., et al. (2012). A newborn with diabetic ketoacidosis and thalassemia major: A rare case. Dicle Tıp Dergisi, 39(1), 142-144. https://doi.org/10.5798/diclemedj.0921.2012.01.0115
AMA Yolbaş İ, Şen V, Balık H, Kelekçi S, Haspolat K, Uluca Ü, Tan İ. A newborn with diabetic ketoacidosis and thalassemia major: A rare case. diclemedj. March 2012;39(1):142-144. doi:10.5798/diclemedj.0921.2012.01.0115
Chicago Yolbaş, İlyas, Velat Şen, Hasan Balık, Selvi Kelekçi, Kenan Haspolat, Ünal Uluca, and İlhan Tan. “A Newborn With Diabetic Ketoacidosis and Thalassemia Major: A Rare Case”. Dicle Tıp Dergisi 39, no. 1 (March 2012): 142-44. https://doi.org/10.5798/diclemedj.0921.2012.01.0115.
EndNote Yolbaş İ, Şen V, Balık H, Kelekçi S, Haspolat K, Uluca Ü, Tan İ (March 1, 2012) A newborn with diabetic ketoacidosis and thalassemia major: A rare case. Dicle Tıp Dergisi 39 1 142–144.
IEEE İ. Yolbaş, “A newborn with diabetic ketoacidosis and thalassemia major: A rare case”, diclemedj, vol. 39, no. 1, pp. 142–144, 2012, doi: 10.5798/diclemedj.0921.2012.01.0115.
ISNAD Yolbaş, İlyas et al. “A Newborn With Diabetic Ketoacidosis and Thalassemia Major: A Rare Case”. Dicle Tıp Dergisi 39/1 (March 2012), 142-144. https://doi.org/10.5798/diclemedj.0921.2012.01.0115.
JAMA Yolbaş İ, Şen V, Balık H, Kelekçi S, Haspolat K, Uluca Ü, Tan İ. A newborn with diabetic ketoacidosis and thalassemia major: A rare case. diclemedj. 2012;39:142–144.
MLA Yolbaş, İlyas et al. “A Newborn With Diabetic Ketoacidosis and Thalassemia Major: A Rare Case”. Dicle Tıp Dergisi, vol. 39, no. 1, 2012, pp. 142-4, doi:10.5798/diclemedj.0921.2012.01.0115.
Vancouver Yolbaş İ, Şen V, Balık H, Kelekçi S, Haspolat K, Uluca Ü, Tan İ. A newborn with diabetic ketoacidosis and thalassemia major: A rare case. diclemedj. 2012;39(1):142-4.