Abstract
Sex cord-stromal tumors account for approximately 7% of all primary ovarian tumors. Sertoli-Leydig Cell Tumors and Granulosa cell tumors are subtype of sex cord stro- mal tumor of the ovary. Sertoli-Leydig Cell Tumors ac- count for less than 0.2-0.5% of all primary ovarian neo- plasms. Granulosa cell tumors account for 3-5% of all primary ovarian neoplasms. Mixed subtype of sex cord stromal tumors are very rare a condition. Very few case reports have been documented in the literature so far. Despite the rather large lesion at the time of diagnosis in sex cord stromal tumors, 80-90% of patients will pres- ent at stage 1. A case of 21-year-old nullipar woman who presented with a 2-month history of a pelvic pain, menor- rhagia, rapidly increasing abdominal distention, and alo- pecia. Pelvic ultrasonography and magnetic resonance imaging revealed 175x170x93 mm septal cystic mass in the left ovary. The patient underwent left unilateral salpin- goophorectomy because of huge septal cystic mass and fertility preserving surgery. In histopathological examina- tion these masses were evaluated as mixed (Granulosa cell/Sertoli-Leydig Cell Tumors) sex cord stromal tumor. This case was chosen and reported due to its rarity and clinical properties
References
- Haroon S, Zia A, Idrees R, et al. Clinicopathological spectrum
- of ovarian sex cord-stromal tumors; 20 years’ retrospective
- study in a developing country. J Ovarian Res 2013;6:87-93.
- Koonings PP, Campbell K, Mishell Jr, et al. Relative frequency
- of primary ovarian neoplasms: a 10-year review. Obstet
- Gynecol 1989;74:921-926.
- Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary.
- J Clin Oncol 2003;21:1180-1189.
- Young RH, Scully RE. Ovarian Sertoli-Leydig cell tumors. A
- clinicopathological analysis of 207 cases. Am J Surg Pathol
- ;9:543-569.
- Gui T, Cao D, Shen K, et al. A clinicopathological analysis
- of 40 cases of ovarian Sertoli-Leydig cell tumors. Gynecol
- Oncol 2012;127:384-389.
- Alam K, Maheshwari V, Rashid S, et al. Bilateral SertoliLeydig
- cell tumour a rare case report. Indian J Pathol Microbiol
- ;52:97-99.
- Chi M, Gilman AD, Iroegbu N. Management of metastatic
- ovarian Sertoli-Leydig cell tumor with sporadic multinodular
- goiter: a case report and literature review. Future Oncol
- ;7:1113-1117.
- Frio TR, Bahubeshi A, Kanellopoulou C, et al. DICER1 mutations
- in familial multi-nodular goiter with and without
- ovarian Sertoli-Leydig cell tumors. JAMA 2011;305:68-77.
- Cai S, Zhao S, Qiang J, et al. Ovarian Sertoli–Leydig cell
- tumors: MRI findings and pathological correlation. J Ovarian
- Res 2013;26:73.
- Alabalık U, Avcı Y, Keleş AN, et al. Five year evaluation of
- intraoperative pathology consultations in a university hospital.
- Dicle Med J 2013;40:207-211.
Abstract
Seks kord stromal tümörler; tüm over tümörlerinin yakla- şık %7’sini oluştururlar. Sertoli-Leydig hücreli tümörler ve granüloza hücreli tümörler overin seks kord stromal tü- mörlerinin alt tiplerindendir. Sertoli-Leydig hücreli tümörler, tüm over tümörlerinin %0,2-0,5’den daha azını oluş- tururlar. Granüloza hücreli tümörler ise tüm over tümörlerinin %3-5’ini oluştururlar. Seks kord stromal tümörün alt tiplerinin birlikte izlenmesi ise çok çok nadir bir durumdur. Bu nedenle bu güne kadar literatürde çok az sayıda vaka bildirilmiştir. Seks kord stromal tümörler tanı konulduğunda büyük kitleler halinde olmasına rağmen, %80-90’ının evre 1’de olduğu gözlenmektedir. Olgumuz 2 aydır devam eden pelvik ağrı, menoraji, giderek artan karın şişliği ve alopesi şikayetleri olan 21 yaşında nullipar hastadır. Hastanın pelvik ultrasonografi ve manyetik rezonans görüntülemelerinde sol overde 175x170x93 mm boyutlarında septalı kistik kitle izlenmiştir. Kistinin septalı olması ve fertilite koruyucu cerrahinin istenmesi nedeniyle sol unilateral salpingooeferektomi uygulanmıştır. Histopatolojik incelemede mikst tip (Granüloza hücreli/Sertoli-Leydig hücreli tümör) seks kord stromal tümör olarak değerlendirilmiştir. Bu olgu nadir görülmesi ve klinik özellikleri nedeni ile yayınlamaya uygun bulunmuştur. Anahtar kelimeler: Granüloza hücreli tümör, manyetik rezonans görüntüleme, over, Sertoli-Leydig hücreli tümör
References
- Haroon S, Zia A, Idrees R, et al. Clinicopathological spectrum
- of ovarian sex cord-stromal tumors; 20 years’ retrospective
- study in a developing country. J Ovarian Res 2013;6:87-93.
- Koonings PP, Campbell K, Mishell Jr, et al. Relative frequency
- of primary ovarian neoplasms: a 10-year review. Obstet
- Gynecol 1989;74:921-926.
- Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary.
- J Clin Oncol 2003;21:1180-1189.
- Young RH, Scully RE. Ovarian Sertoli-Leydig cell tumors. A
- clinicopathological analysis of 207 cases. Am J Surg Pathol
- ;9:543-569.
- Gui T, Cao D, Shen K, et al. A clinicopathological analysis
- of 40 cases of ovarian Sertoli-Leydig cell tumors. Gynecol
- Oncol 2012;127:384-389.
- Alam K, Maheshwari V, Rashid S, et al. Bilateral SertoliLeydig
- cell tumour a rare case report. Indian J Pathol Microbiol
- ;52:97-99.
- Chi M, Gilman AD, Iroegbu N. Management of metastatic
- ovarian Sertoli-Leydig cell tumor with sporadic multinodular
- goiter: a case report and literature review. Future Oncol
- ;7:1113-1117.
- Frio TR, Bahubeshi A, Kanellopoulou C, et al. DICER1 mutations
- in familial multi-nodular goiter with and without
- ovarian Sertoli-Leydig cell tumors. JAMA 2011;305:68-77.
- Cai S, Zhao S, Qiang J, et al. Ovarian Sertoli–Leydig cell
- tumors: MRI findings and pathological correlation. J Ovarian
- Res 2013;26:73.
- Alabalık U, Avcı Y, Keleş AN, et al. Five year evaluation of
- intraoperative pathology consultations in a university hospital.
- Dicle Med J 2013;40:207-211.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | May 9, 2015 |
| Submission Date | May 9, 2015 |
| Published in Issue | Year 2015 Volume: 42 Issue: 1 |