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Year 2015, Volume: 42 Issue: 3, 368 - 372, 24.10.2015

Esma Bilgi Hafize Sav Gökmen Zararsız Fatma Özakkaş Nuri Kıraz

https://doi.org/10.5798/diclemedj.0921.2015.03.0591

Abstract

Objective: Candidemia is the fourth most common infection among nosocomial blood circulation infections. Although Candida albicans is the most frequently identified species in invasive candidiasis, incidence of non-albicans Candida species were increased especially among critically ill patients. This reflects the changes in clinical practice. The main objective of the present study is to determine the distribution of the Candida species that causes candidemia in our hospital and contributes to the prevention of nosocomial infections. Methods: In a retrospective study on candidemia, various Candida species isolated from blood cultures were evaluated and their epidemiological, clinical, and microbiological characteristics were determined.Results: A total of 200 species of Candida were identified and the distribution was as follows: 38% C. albicans, 24.5% C. parapsilosis, 16.5% C. tropicalis, 13% C. glabrata, 3% C. krusei, 2% C. sake, 1% C. lusitaniae, 0.5% C. guilliermondii. The highest amounts of (103/200; 51.5%) of Candida species were identified at the adult intensive care unit.Conclusion: Parallel to the increase in the patient population that is as risk for Candida infections, epidemiological studies should be made to identify the species and develop effective treatment protocols

Keywords

Candida candidemia invasive candida infection epidemiology

References

  • Hidron AI, Edwards JR, Patel J, et al. NSHN annual update:
  • antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008;29:996-1011.
  • Kett DH, Azoulay E, Echeverria PM, Vincent JL. Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med 2011;39:665-670.
  • Wisplinghoff H, Bischoff T, Tallent SM, et al. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study.Clin Infect Dis 2004;39:309-317.
  • Guo F, Yang Y, Kang Y, et al. Invasive candidiasis in intensive
  • care units in China: a multicentre prospective observational study. J Antimicrob Chemother 2013;68:1660-1668.
  • Ells R, Kock JLF, Pohl CH. Candida albicans or Candida dubliniensis? Mycoses 2011;54:1-16.
  • Wey SB, Mori M, Pfaller MA, et al. Hospital acquired candidemia:
  • The attributable mortality and excess lengthy of stay. Arch Intern Med 1988;148:2642-2645.
  • Chen LY, Yang SP, Chen TL, et al. Clinical significance of time to positivity for yeast in candidemia. J Microbiol Immunol Infect 2015;48:425-430.
  • Ma CF, Li FQ, Shi LN, et al. Surveillance study of species distribution, antifungal susceptibility and mortality of nosocomial candidemia in a tertiary care hospital in China. BMC Infect Dis 2013;13:337.
  • Bouza E, Muñoz P. Epidemiology of candidemia in intensive
  • care units. Int J Antimicrob Agents 2008;32(Suppl 2):87-91.
  • Ruan SY, Lee LN, Jerng JS, et al. Candida glabrata fungaemia
  • in intensive care units. Clin Microbiol Infect 2008;14:136-140.
  • Montagna MT, Lovero G, Borghi E, et al. Candidemia in intensive care unit: a nationwide prospective observational survey (GISIA-3 tudy) and review of the European literature from 2000 through 2013. Eur Rev Med Pharmacol Sci2014;18:661-674.
  • Meyer E, Geffer C, Gastmeier P, Schwab F. No increase in primary nosocomial candidemia in 682 German intensive care units during 2006 to 2011. Euro Surveill 2013;18:20505.
  • Nawrot U, Pajaczkowska M, Fleischer M, et al. Candidaemia in polish hospitals - a multicentre survey. Mycoses 2013;56:576-581.
  • Bergamasco MD, Garnica M, Colombo AL, Nucci M. Epidemiology of candidemia in patients with hematologic malignancies and solid tumours in Brazil. Mycoses 2013;56:256-263.
  • Çalışkan E, Dede A, Biten Güven G. Distribution and antifungal
  • susceptibilities of Candida species isolated from blood cultures. Ankem 2013;27:25-30.
  • Atalay MA, Sav H, Demir G, Koç AN. Distribution of candida species ısolated from blood cultures and in-vitro susceptibilities
  • to Amphotericin b and Fluconazole. Medical Journal of Selçuk 2012;28:149-151.
  • Gültekin B, Eyigör M, Telli M, et al. A Retrospective Investigation
  • of Candida Species Isolated from Blood Cultures during a seven-year period. Ankem 2010;24:202-208.
  • Aslan U, Uysal EB, Işık F, et al. Candida species isolated in blood samples, 2002-2005 İnfeksiyon Derg 2006;20:177-181.
  • Yenigün Koçak B, Kuloğlu F, Doğan Çelik A, Akata F. Evaluation of Epidemiological Characteristics and Risk Factors of Candidemia in Adult Patients in a Tertiary-Care Hospital. Mikrobiyol Bul 2011;45:489-503.
  • Yapar N, Pullukcu H, Avkan-Oguz V, et al. Evaluation of
  • species distribution and risk factors of candidemia: a multicenter
  • case-control study. Med Mycol 2011;49:26-31.

Distribution of Candida species isolated from blood cultures in a university hospital

Year 2015, Volume: 42 Issue: 3, 368 - 372, 24.10.2015

Esma Bilgi Hafize Sav Gökmen Zararsız Fatma Özakkaş Nuri Kıraz

https://doi.org/10.5798/diclemedj.0921.2015.03.0591

Abstract

Amaç: Kandidemi, nozokomiyal kan dolaşımı enfeksiyonları arasında dördüncü sırada yer almaktadır. İnvaziv kandidiyazda Candida albicans halen en sık tanımlanan patojen olsa da, albicans dışı kandida türlerine bağlı enfeksiyonlarda dramatik artış dikkati çekmektedir bu durum, klinik uygulamadaki değişimleri yansıtmaktadır. Bu çalışmanın temel amacı kandidemi etkeni Candida türlerinin hastanemizdeki dağılımını belirleyerek hastane enfeksiyonlarının önlenmesine katkıda bulunmaktır.

Yöntemler: Retrospektif (2013-2014) bu çalışmada kan kültürlerinden izole edilen Candida türlerinin epidemiyolojik, klinik ve mikrobiyolojik karakteristikleri bildirilmiştir.

Bulgular: Toplam 200 Candida spp türü %38 C. albicans, %24,5 C. parapsilosis, %16,5 C. tropicalis, %13 C. glabrata, %3 C. krusei, %2 C. sake, %1 C. lusitaniae, %0,5 C. guilliermondii olarak tanımlanmıştır. Tanımlanan Candida türleri en yüksek oranla (103/200; %51,5) yoğun bakım ünitesinde saptanmıştır.

Sonuç: Candida infeksiyonları için risk teşkil eden hasta popülasyonunun artmasına paralel olarak, türlerin tanımlanması ve etkin tedavi protokollerinin geliştirilmesi için epidemiyolojik çalışmaların yapılması gerekmektedir.

Anahtar kelimeler: Candida, kandidemi, invaziv kandida infeksiyonu, epidemiyoloji

Keywords

Candida kandidemi invaziv kandida infeksiyonu epidemiyoloji

References

  • Hidron AI, Edwards JR, Patel J, et al. NSHN annual update:
  • antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008;29:996-1011.
  • Kett DH, Azoulay E, Echeverria PM, Vincent JL. Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med 2011;39:665-670.
  • Wisplinghoff H, Bischoff T, Tallent SM, et al. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study.Clin Infect Dis 2004;39:309-317.
  • Guo F, Yang Y, Kang Y, et al. Invasive candidiasis in intensive
  • care units in China: a multicentre prospective observational study. J Antimicrob Chemother 2013;68:1660-1668.
  • Ells R, Kock JLF, Pohl CH. Candida albicans or Candida dubliniensis? Mycoses 2011;54:1-16.
  • Wey SB, Mori M, Pfaller MA, et al. Hospital acquired candidemia:
  • The attributable mortality and excess lengthy of stay. Arch Intern Med 1988;148:2642-2645.
  • Chen LY, Yang SP, Chen TL, et al. Clinical significance of time to positivity for yeast in candidemia. J Microbiol Immunol Infect 2015;48:425-430.
  • Ma CF, Li FQ, Shi LN, et al. Surveillance study of species distribution, antifungal susceptibility and mortality of nosocomial candidemia in a tertiary care hospital in China. BMC Infect Dis 2013;13:337.
  • Bouza E, Muñoz P. Epidemiology of candidemia in intensive
  • care units. Int J Antimicrob Agents 2008;32(Suppl 2):87-91.
  • Ruan SY, Lee LN, Jerng JS, et al. Candida glabrata fungaemia
  • in intensive care units. Clin Microbiol Infect 2008;14:136-140.
  • Montagna MT, Lovero G, Borghi E, et al. Candidemia in intensive care unit: a nationwide prospective observational survey (GISIA-3 tudy) and review of the European literature from 2000 through 2013. Eur Rev Med Pharmacol Sci2014;18:661-674.
  • Meyer E, Geffer C, Gastmeier P, Schwab F. No increase in primary nosocomial candidemia in 682 German intensive care units during 2006 to 2011. Euro Surveill 2013;18:20505.
  • Nawrot U, Pajaczkowska M, Fleischer M, et al. Candidaemia in polish hospitals - a multicentre survey. Mycoses 2013;56:576-581.
  • Bergamasco MD, Garnica M, Colombo AL, Nucci M. Epidemiology of candidemia in patients with hematologic malignancies and solid tumours in Brazil. Mycoses 2013;56:256-263.
  • Çalışkan E, Dede A, Biten Güven G. Distribution and antifungal
  • susceptibilities of Candida species isolated from blood cultures. Ankem 2013;27:25-30.
  • Atalay MA, Sav H, Demir G, Koç AN. Distribution of candida species ısolated from blood cultures and in-vitro susceptibilities
  • to Amphotericin b and Fluconazole. Medical Journal of Selçuk 2012;28:149-151.
  • Gültekin B, Eyigör M, Telli M, et al. A Retrospective Investigation
  • of Candida Species Isolated from Blood Cultures during a seven-year period. Ankem 2010;24:202-208.
  • Aslan U, Uysal EB, Işık F, et al. Candida species isolated in blood samples, 2002-2005 İnfeksiyon Derg 2006;20:177-181.
  • Yenigün Koçak B, Kuloğlu F, Doğan Çelik A, Akata F. Evaluation of Epidemiological Characteristics and Risk Factors of Candidemia in Adult Patients in a Tertiary-Care Hospital. Mikrobiyol Bul 2011;45:489-503.
  • Yapar N, Pullukcu H, Avkan-Oguz V, et al. Evaluation of
  • species distribution and risk factors of candidemia: a multicenter
  • case-control study. Med Mycol 2011;49:26-31.
There are 30 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Esma Bilgi This is me

Hafize Sav This is me

Gökmen Zararsız This is me

Fatma Özakkaş This is me

Nuri Kıraz This is me

Publication Date October 24, 2015
Submission Date October 24, 2015
Published in Issue Year 2015 Volume: 42 Issue: 3

Cite

APA Bilgi, E., Sav, H., Zararsız, G., Özakkaş, F., et al. (2015). Distribution of Candida species isolated from blood cultures in a university hospital. Dicle Medical Journal, 42(3), 368-372. https://doi.org/10.5798/diclemedj.0921.2015.03.0591
AMA Bilgi E, Sav H, Zararsız G, Özakkaş F, Kıraz N. Distribution of Candida species isolated from blood cultures in a university hospital. diclemedj. November 2015;42(3):368-372. doi:10.5798/diclemedj.0921.2015.03.0591
Chicago Bilgi, Esma, Hafize Sav, Gökmen Zararsız, Fatma Özakkaş, and Nuri Kıraz. “Distribution of Candida Species Isolated from Blood Cultures in a University Hospital”. Dicle Medical Journal 42, no. 3 (November 2015): 368-72. https://doi.org/10.5798/diclemedj.0921.2015.03.0591.
EndNote Bilgi E, Sav H, Zararsız G, Özakkaş F, Kıraz N (November 1, 2015) Distribution of Candida species isolated from blood cultures in a university hospital. Dicle Medical Journal 42 3 368–372.
IEEE E. Bilgi, H. Sav, G. Zararsız, F. Özakkaş, and N. Kıraz, “Distribution of Candida species isolated from blood cultures in a university hospital”, diclemedj, vol. 42, no. 3, pp. 368–372, 2015, doi: 10.5798/diclemedj.0921.2015.03.0591.
ISNAD Bilgi, Esma et al. “Distribution of Candida Species Isolated from Blood Cultures in a University Hospital”. Dicle Medical Journal 42/3 (November 2015), 368-372. https://doi.org/10.5798/diclemedj.0921.2015.03.0591.
JAMA Bilgi E, Sav H, Zararsız G, Özakkaş F, Kıraz N. Distribution of Candida species isolated from blood cultures in a university hospital. diclemedj. 2015;42:368–372.
MLA Bilgi, Esma et al. “Distribution of Candida Species Isolated from Blood Cultures in a University Hospital”. Dicle Medical Journal, vol. 42, no. 3, 2015, pp. 368-72, doi:10.5798/diclemedj.0921.2015.03.0591.
Vancouver Bilgi E, Sav H, Zararsız G, Özakkaş F, Kıraz N. Distribution of Candida species isolated from blood cultures in a university hospital. diclemedj. 2015;42(3):368-72.