The importance of clinical and pathological features in bladder cancer and its effects on disease course

Year 2019, Volume: 46 Issue: 4, 821 - 829, 15.12.2019

Sahin Lacin Nilgun Sogutcu

https://doi.org/10.5798/dicletip.661400

Abstract

Objective: Bladder cancer (BC) is the most common malignancy of the urinary system and the incidence of BC varies
regionally. Bladder cancer is more common in men than in women. Tumor stage and grade are the most important
prognostic factors of BC. We aimed to describe the patterns of BC presentation and to examine the differences in the
distribution of prognostic factors by gender, age, tumor size, and involvement region.
Method: The patients diagnosed with BC (non-muscle invasive or muscle-invasive BC) were included. Intravesical
treatment, tumor diameter, pathological grade, tumor involved area and tumor stage were recorded as variables. The
survival rates of the patients were calculated for diverse clinical and pathological findings.
Results:In a total of 124 patients, 23 (18.5%) of patients were female and 101(81.5%) of patients were male, the
median age of all patients was 64 (IQR: 21-92). There were 36 % (41) patients in early-stage (stage 0 or stage insitu),
50.9 % (58) patients in stage 1, 7% (8) patients in stage 2, 4.4 %(5) patients in stage 3 and 1.8% (2) patients were in
stage 4. There were significantly different OS rates of patients with BC in different stages (p<0.001). Tumor diameter
in 36 of patients was < 2.5cm (group 1) and tumor diameter in 28 patients was>2.5cm (group 2). There was a
significant difference between the overall survival rates of group 1 and group 2(p=0.02). There were 55 patients with
low-grade BC and 38 of patients with high-grade BC, and the difference between their survival rates was statistically
significant (p=0.001).
Conclusions: Tumor stage, tumor diameter, and grade were demonstrated and confirmed as the crucial prognostic
factors of bladder cancer. Additionally, lateral walls of bladder constitute the most commonly involved area, but their
roles in the disease course still remain unclear.

Keywords

Bladder cancer, Tumor size

References

• 1. Ploeg M, Aben KK, KiemeneyLA.The present and future burden of urinary bladder cancer in the world. World J Urol. 2009;27:289-293.